Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Bethany L. MacLeod"'
Autor:
Ramy Gadalla, Babak Noamani, Bethany L. MacLeod, Russell J. Dickson, Mengdi Guo, Wenxi Xu, Sabelo Lukhele, Heidi J. Elsaesser, Albiruni R. Abdul Razak, Naoto Hirano, Tracy L. McGaha, Ben Wang, Marcus Butler, Cynthia J. Guidos, Pam S. Ohashi, Lillian L. Siu, David G. Brooks
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Flow cytometry is a widely applied approach for exploratory immune profiling and biomarker discovery in cancer and other diseases. However, flow cytometry is limited by the number of parameters that can be simultaneously analyzed, severely restrictin
Externí odkaz:
https://doaj.org/article/634646a4f4a340d1ae9adab5f45ea2de
Autor:
Nicholas Collins, Xiaodong Jiang, Ali Zaid, Bethany L. Macleod, Jane Li, Chang Ook Park, Ashraful Haque, Sammy Bedoui, William R. Heath, Scott N. Mueller, Thomas S. Kupper, Thomas Gebhardt, Francis R. Carbone
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Memory T cells are vital responders to skin inflammation, but cell localization and dynamics of exchange with the bloodstream are not clear. Here the authors use parabiosis and intravital microscopy to show that CD4+memory T cells equilibrate with th
Externí odkaz:
https://doaj.org/article/9429c534091c48ec9b67d0bb26d4ecdf
Autor:
Bethany L. MacLeod, W. Xu, Giselle Boukhaled, Sabelo Lukhele, Diala Abd-Rabbo, Mengdi Guo, Laura M. Snell, Sara Nejat, Heidi Elsaesser, Tracy L. McGaha, Slava Epelman, Kebria Hezaveh, David G. Brooks, Ramanandan Prabhakaran, Nirmin Alsahafi
Publikováno v:
Nature Immunology. 22:1524-1537
Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4+ T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4+ helper T (TH) cell responses or the ability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4003e48e6cfcf2bf99d001784cba3781
https://doi.org/10.1038/s41590-021-01060-7
https://doi.org/10.1038/s41590-021-01060-7
Autor:
Laura M, Snell, Wenxi, Xu, Diala, Abd-Rabbo, Giselle, Boukhaled, Mengdi, Guo, Bethany L, Macleod, Heidi J, Elsaesser, Kebria, Hezaveh, Nirmin, Alsahafi, Sabelo, Lukhele, Sara, Nejat, Ramanandan, Prabhakaran, Slava, Epelman, Tracy L, McGaha, David G, Brooks
Publikováno v:
Nat Immunol
Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4(+) T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4(+) helper T (T(H)) cell responses or the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::828b63e1cb80f691d1a66c712b315fa5
https://pubmed.ncbi.nlm.nih.gov/34795443
https://pubmed.ncbi.nlm.nih.gov/34795443
Autor:
Marie Jo Halaby, Vincenzo Bronte, Andreas Kloetgen, Trevor J. Pugh, David G. Brooks, Kebria Hezaveh, M. Teresa Ciudad, Tracy L. McGaha, Daniel D. De Carvalho, Mengdi Guo, David H. Munn, Sara Lamorte, Aristotelis Tsirigos, Bethany L. MacLeod, Marcus O. Butler, Stefano Ugel, Tiago Medina, Ankur Chakravarthy, Pamela S. Ohashi
Publikováno v:
Sci Immunol
General control nonderepressible 2 (GCN2) is an environmental sensor controlling transcription and translation in response to nutrient availability. Although GCN2 is a putative therapeutic target for immuno-oncology, its role in shaping the immune re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620ad4b7d97c7326aeb68be236a88fa8
https://doi.org/10.1126/sciimmunol.aax8189
https://doi.org/10.1126/sciimmunol.aax8189
Autor:
Bethany L. MacLeod, Laura M. Snell, Russell J. Dickson, Kebria Hezaveh, Cynthia J. Guidos, Mengdi Guo, Heidi Elsaesser, W. Xu, Tracy L. McGaha, David G. Brooks, Akash Kothari
Publikováno v:
The Journal of Experimental Medicine
Macleod et al. uncover how chronic viral infection modulates gastrointestinal immune and microbial composition to foster persistence and long-term disease susceptibilities. The authors also identify the central role of regulatory T cells to maintain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647516dc2ff912df7f89798c277ca1a3
https://pubmed.ncbi.nlm.nih.gov/32880629
https://pubmed.ncbi.nlm.nih.gov/32880629
Autor:
Wenxi Xu, Laura M. Snell, Mengdi Guo, Giselle Boukhaled, Bethany L. Macleod, Ming Li, Michael V. Tullius, Cynthia J. Guidos, Ming-Sound Tsao, Maziar Divangahi, Marcus A. Horwitz, Jun Liu, David G. Brooks
Publikováno v:
The Journal of Immunology. 206:62.08-62.08
Chronic viral infections increase severity of Mycobacterium tuberculosis (Mtb) coinfection, yet how they alter the pulmonary microenvironment to foster coinfection and worsen disease severity is unclear. We developed a coinfection model in mice with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936af5fe858c8a05568e867236fa6ab7
https://doi.org/10.4049/jimmunol.206.supp.62.08
https://doi.org/10.4049/jimmunol.206.supp.62.08
Autor:
Bethany L. MacLeod, Michael V. Tullius, Ming-Sound Tsao, Jun Liu, W. Xu, Ming Li, Maziar Divangahi, Giselle M. Boukhaled, David G. Brooks, Laura M. Snell, Mengdi Guo, Marcus A. Horwitz, Cynthia J. Guidos
Publikováno v:
Immunity
Summary Chronic viral infections increase severity of Mycobacterium tuberculosis (Mtb) coinfection. Here, we examined how chronic viral infections alter the pulmonary microenvironment to foster coinfection and worsen disease severity. We developed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e5eb538152f1934178db00f08f19ba
https://doi.org/10.1016/j.immuni.2021.01.003
https://doi.org/10.1016/j.immuni.2021.01.003
Autor:
Thomas S. Kupper, Ashraful Haque, Nicholas Collins, Sammy Bedoui, Jane Li, Scott N. Mueller, Bethany L. Macleod, William R. Heath, Francis R. Carbone, Ali Zaid, Xiaodong Jiang, Chang Ook Park, Thomas Gebhardt
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4+ T cells in mouse skin are in equilibrium with the circulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7124f2169a6a29cc291be96d7331ef87
https://doaj.org/article/9429c534091c48ec9b67d0bb26d4ecdf
https://doaj.org/article/9429c534091c48ec9b67d0bb26d4ecdf
Autor:
Sanda Stankovic, Andrew G. Brooks, Paul G. Whitney, Bethany L. Macleod, Christopher M. Harpur, Thomas Gebhardt
Publikováno v:
The Journal of Immunology. 195:4892-4899
The ability of CD4 T cells to give rise to specialized T follicular helper cells (TFH) critical to initiating appropriate Ab responses is regulated by environmental cues in lymphoid tissues draining the site of infection. In this study, we used a ski
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1735beb5d2352269da41c0f95e30292f
https://doi.org/10.4049/jimmunol.1500247
https://doi.org/10.4049/jimmunol.1500247