Výsledky vyhledávání - "Bethany L. Dale"

Akademický článek

The NLRP3 Inflammasome: Relevance in Solid Organ Transplantation

Autor: Ryan M. Burke, Bethany L. Dale, Shamik Dholakia

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 19, p 10721 (2021)

The NOD, LRR, and pyrin domain-containing 3 (NLRP3) protein has been established as a central component of the inflammasome and regulates the inflammatory response to a myriad of environmental, microbial, and endogenous danger stimuli. Assembly of th

Externí odkaz: https://doaj.org/article/181d28501e114b47a45ee6b6c85f5afe

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Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension

Autor: Matthew R. Alexander, Bethany L. Dale, Charles D. Smart, Fernando Elijovich, Cara E. Wogsland, Sierra M. Lima, Jonathan M. Irish, Meena S. Madhur

Publikováno v: JACC Basic Transl Sci

Evidence from nonhuman animal models demonstrates an important role for immune cells in hypertension, but immune cell changes in human hypertension are less clear. Using mass cytometry, we demonstrate novel and selective reductions in CCR10(+) regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f8fa0b4458a089cebe8ef8140b0de2
https://doi.org/10.1016/j.jacbts.2022.09.007

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A Single Nucleotide Polymorphism in

Autor: Matthew R, Alexander, Samuel, Hank, Bethany L, Dale, Lauren, Himmel, Xue, Zhong, Charles D, Smart, Daniel J, Fehrenbach, Yuhan, Chen, Nitin, Prabakaran, Brian, Tirado, Megan, Centrella, Mingfang, Ao, Liping, Du, Yu, Shyr, Daniel, Levy, Meena S, Madhur

Publikováno v: Circulation research. 131(9)

SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively regulates cytokine signaling and cell proliferation. A common missense single nucleotide polymorphism inWe used CRISPR-Cas9 technology to create mice homozygous for the major (Arg/A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ec1c449b25f5da4d3d7921142c8d695
https://pubmed.ncbi.nlm.nih.gov/36169218

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A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage

Autor: Matthew R. Alexander, Samuel Hank, Bethany L. Dale, Lauren Himmel, Xue Zhong, Charles D. Smart, Daniel J. Fehrenbach, Yuhan Chen, Nitin Prabakaran, Brian Tirado, Megan Centrella, Mingfang Ao, Liping Du, Yu Shyr, Daniel Levy, Meena S. Madhur

Publikováno v: Circulation Research. 131:731-747

Background: SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively regulates cytokine signaling and cell proliferation. A common missense single nucleotide polymorphism in SH2B3 (rs3184504) results in substitution of tryptophan (Trp) fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eda42aaef1275cc35f45497e9b0111f7
https://doi.org/10.1161/circresaha.121.320625

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Class switching and high-affinity immunoglobulin G production by B cells is dispensable for the development of hypertension in mice

Autor: Yuhan Chen, Bethany L. Dale, Meena S. Madhur, Gwendolyn K Davis, Matthew R Alexander, Charles D Smart, Mingfang Ao, Liang Xiao, Arvind K. Pandey

Publikováno v: Cardiovasc Res

Aims Elevated serum immunoglobulins have been associated with experimental and human hypertension for decades but whether immunoglobulins and B cells play a causal role in hypertension pathology is unclear. In this study, we sought to determine the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadea200e611d9823df0b6808a2b1a51
https://doi.org/10.1093/cvr/cvaa187

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The NLRP3 Inflammasome: Relevance in Solid Organ Transplantation

Autor: Bethany L. Dale, Ryan M. Burke, Shamik Dholakia

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10721, p 10721 (2021)
International Journal of Molecular Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aca30ef26c5fa1d2ef031da1bd380f2
https://www.mdpi.com/1422-0067/22/19/10721

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Abstract MP49: Single Cell Multiplex Immunophenotyping Using Mass Cytometry And CITE-Seq Reveals Decreases In Circulating PD-1 + CD8 + Memory T Cells With Features Of Exhaustion In Human Hypertension

Autor: Jonathan M. Irish, Matthew R Alexander, Fernando Elijovich, Cara E. Wogsland, Charles D Smart, Bethany L. Dale, Sierra Barone, Meena S. Madhur

Publikováno v: Hypertension. 78

Emerging evidence from animal models has demonstrated the importance of multiple innate and adaptive immune cells in hypertension. We hypothesized that the abundance and phenotype of circulating immune cell subsets are altered in human hypertension.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43590120a6eb1707bed1d90f5d2613c4
https://doi.org/10.1161/hyp.78.suppl_1.mp49

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Transition of Renal Patients Using AlloSure Into Community Kidney Care (TRACK): Protocol for Long-Term Allograft Surveillance in Renal Transplant Recipients

Autor: Jenna Short, Pierre Daou, Bethany L Dale, Alana Burns, Sheng Kuo, Subhasish Bose, Jake Miles

Publikováno v: JMIR Research Protocols, Vol 10, Iss 3, p e25941 (2021)
JMIR Research Protocols

Background Patients with end-stage kidney disease require complex and expensive medical management. Kidney transplantation remains the treatment of choice for end-stage kidney disease and is considered superior to all other modalities of renal replac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8175a188945295c83d789bd14af83ec3
https://www.researchprotocols.org/2021/3/e25941

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