Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Bethany C Taylor"'
Autor:
Kanishk Jain, Matthew R Marunde, Jonathan M Burg, Susan L Gloor, Faith M Joseph, Karl F Poncha, Zachary B Gillespie, Keli L Rodriguez, Irina K Popova, Nathan W Hall, Anup Vaidya, Sarah A Howard, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Emily F Patteson, Spencer W Cooke, Bethany C Taylor, Ellen N Weinzapfel, Marcus A Cheek, Matthew J Meiners, Geoffrey C Fox, Kevin EW Namitz, Martis W Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S Cosgrove, Nicolas L Young, Michael-Christopher Keogh, Brian D Strahl
Publikováno v:
eLife, Vol 12 (2023)
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylat
Externí odkaz:
https://doaj.org/article/4578fc571e78426c9ad347f2e09aa9c9
Autor:
Lyra Chang, James Campbell, Idris O. Raji, Shiva K. R. Guduru, Prasanna Kandel, Michelle Nguyen, Steven Liu, Kevin Tran, Navneet K. Venugopal, Bethany C. Taylor, Matthew V. Holt, Nicolas L. Young, Errol L. G. Samuel, Prashi Jain, Conrad Santini, Banumathi Sankaran, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isol
Externí odkaz:
https://doaj.org/article/5972f93c7d5b4a20bcf0f3bca4897227
Autor:
Bethany C. Taylor, Nicolas L. Young
Publikováno v:
Analytical and Bioanalytical Chemistry. 415:1627-1639
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5020f4d65c188a25e5a443e1f0ddf39d
https://doi.org/10.1007/s00216-023-04555-4
https://doi.org/10.1007/s00216-023-04555-4
Autor:
Bethany C Taylor, Nicolas L. Young
Publikováno v:
Biochemical Journal. 478:511-532
Histones are essential proteins that package the eukaryotic genome into its physiological state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) of histones are crucial to both the dynamic and persistent regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c5a775f8068bc860d9c9f3065108b0
https://doi.org/10.1042/bcj20200170
https://doi.org/10.1042/bcj20200170
Autor:
Kanishk Jain, Matthew R Marunde, Jonathan M Burg, Susan L Gloor, Faith M Joseph, Karl F Poncha, Zachary B Gillespie, Keli L Rodriguez, Irina K Popova, Nathan W Hall, Anup Vaidya, Sarah A Howard, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Emily F Patteson, Spencer W Cooke, Bethany C Taylor, Ellen N Weinzapfel, Marcus A Cheek, Matthew J Meiners, Geoffrey C Fox, Kevin EW Namitz, Martis W Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S Cosgrove, Nicolas Young, Michael-C Keogh, Brian D Strahl
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56293051dfd39cb6a2645e19d0fa20ad
https://doi.org/10.1101/2022.02.28.482307
https://doi.org/10.1101/2022.02.28.482307
Autor:
Nicolas L. Young, Sae-Woong Oh, Caleb A. Wood, Jun Li, Joanna L. Jankowsky, Kyung Won Park, Bethany C Taylor
Publikováno v:
Mol Ther
Numerous aggregation inhibitors have been developed with the goal of blocking or reversing toxic amyloid formation in vivo. Previous studies have used short peptide inhibitors targeting different amyloid β (Aβ) amyloidogenic regions to prevent aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c1f6fae879ea1e50e36c8bcada7979
https://europepmc.org/articles/PMC8261072/
https://europepmc.org/articles/PMC8261072/
Autor:
Navneet K Venugopal, Matthew V. Holt, Bethany C Taylor, Conrad Santini, James C. Campbell, Damian W. Young, Prashi Jain, Idris O. Raji, Shiva Krishna Reddy Guduru, Steven Liu, Errol L.G. Samuel, Kevin Tran, Prasanna Kandel, Lyra Chang, Kevin R. MacKenzie, Banumathi Sankaran, Nicolas L. Young, Michelle Nguyen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isolated UHRF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79af6afde76573cc34c5d34fb4a11975
https://doi.org/10.1038/s41598-020-80588-4
https://doi.org/10.1038/s41598-020-80588-4
Autor:
Bethany C. Taylor, Loic H. Steinthal, Michelle Dias, Hari Krishna Yalamanchili, Scott A. Ochsner, Gladys E. Zapata, Nitesh R. Mehta, Neil J. McKenna, Nicolas L. Young, Alli M. Nuotio-Antar
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-25 (2024)
Abstract Background Regulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with implications for the treatment of obesity and diabetes. Our preliminary analyses of RNA-Seq data uncovered m
Externí odkaz:
https://doaj.org/article/fc14bf05b4604af4a1794b16b46ae69f