Výsledky vyhledávání - "Bethany A. Nagy"

Akademický článek

Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population

Autor: Dimitris Stellas, Sevasti Karaliota, Vasiliki Stravokefalou, Matthew Angel, Bethany A. Nagy, Katherine C. Goldfarbmuren, Cristina Bergamaschi, Barbara K. Felber, George N. Pavlakis

Publikováno v: Cell Reports, Vol 42, Iss 5, Pp 112501- (2023)

Summary: Locoregional monotherapy with heterodimeric interleukin (IL)-15 (hetIL-15) in a triple-negative breast cancer (TNBC) orthotopic mouse model resulted in tumor eradication in 40% of treated mice, reduction of metastasis, and induction of immun

Externí odkaz: https://doaj.org/article/9e387cab5379408199dc1ddc4d8c3d48

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Akademický článek

Heterodimeric IL-15 (hetIL-15) reduces circulating tumor cells and metastasis formation improving chemotherapy and surgery in 4T1 mouse model of TNBC

Autor: Vasiliki Stravokefalou, Dimitris Stellas, Sevasti Karaliota, Bethany A. Nagy, Antonio Valentin, Cristina Bergamaschi, Konstantinos Dimas, George N. Pavlakis

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

Immunotherapy has emerged as a viable approach in cancer therapy, with cytokines being of great interest. Interleukin IL-15 (IL-15), a cytokine that supports cytotoxic immune cells, has been successfully tested as an anti-cancer and anti-metastatic a

Externí odkaz: https://doaj.org/article/2b9cb05ca9884ddbbe501fcf04cf4111

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Akademický článek

Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10

Autor: Bernard A Fox, Cristina Bergamaschi, George N Pavlakis, Antonio Valentin, Jenifer Bear, Barbara K Felber, Shawn M Jensen, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Maggie Cam

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8+ T and natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine, comprising the IL-15 and IL-15 receptor alpha chains (hetIL-15).

Externí odkaz: https://doaj.org/article/2686c70aeb584a37955fa177f72ca91d

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Data from Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion

Autor: George N. Pavlakis, Cristina Bergamaschi, Barbara K. Felber, Bernard A. Fox, Candido Alicea, Xintao Hu, Shawn M. Jensen, Bethany A. Nagy, Sinnie Sin Man Ng

Purpose: Adoptive cell transfer (ACT) is a promising immunotherapeutic approach for cancer. Host lymphodepletion is associated with favorable ACT therapy outcomes, but it may cause detrimental effects in humans. We tested the hypothesis that IL15 adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a5e47a5370b59a570b6d9244df9cef
https://doi.org/10.1158/1078-0432.c.6525200

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Supplementary Figures 1-5, Supplementary Table 1 from Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion

Autor: George N. Pavlakis, Cristina Bergamaschi, Barbara K. Felber, Bernard A. Fox, Candido Alicea, Xintao Hu, Shawn M. Jensen, Bethany A. Nagy, Sinnie Sin Man Ng

Supplementary Figure 1. IL-15 availability promotes proliferation and maintenance of transferred CD8+ T in the spleen of recipient mice; Supplementary Figure 2. Gating strategy for the identification of adoptively transferred Pmel-1 cells and endogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcfc80fca6140c5fd936ffa99addb74
https://doi.org/10.1158/1078-0432.22462775.v1

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Regression and Eradication of Triple-Negative Breast Carcinoma in 4T1 Mouse Model by Combination Immunotherapies

Autor: Saifun Nahar, Yue Huang, Bethany A. Nagy, John A. Zebala, Dean Y. Maeda, Udo Rudloff, Joost J. Oppenheim, De Yang

Publikováno v: Cancers; Volume 15; Issue 8; Pages: 2366

Triple-negative breast carcinoma (TNBC) is one of the most aggressive types of solid-organ cancers. While immune checkpoint blockade (ICB) therapy has significantly improved outcomes in certain types of solid-organ cancers, patients with immunologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4708ba6a87ca93462a701567f019ad53
https://doi.org/10.3390/cancers15082366

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Abstract 3259: heterodimeric IL-15 monotherapy results in complete regression of EO771 murine breast tumors through cDC1-lymphocyte interactions and induction of antitumor immunity

Autor: Dimitris Stellas, Sevasti Karaliota, Vasiliki Stravokefalou, Bethany A. Nagy, Barbara K. Felber, George N. Pavlakis

Publikováno v: Cancer Research. 79:3259-3259

Introduction: IL-15 is a cytokine important for the maintenance, proliferation and activation of lymphocytes, including CD8+ T and natural killer (NK) cells. The native form of IL-15 is a heterodimer either embedded in the plasma membrane or released

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20212be24f76ccf6b06f6022d93125be
https://doi.org/10.1158/1538-7445.am2019-3259

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