Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bethan Young"'
Autor:
Bethan Young, John Stephenson, Barira Islam, Nikita N. Burke, Elaine M. Jennings, David P. Finn, Patrick C. McHugh
Publikováno v:
Molecular Neurobiology. 60:1179-1194
Neuropathic pain is a common chronic condition, which remains poorly understood. Many patients receiving treatment continue to experience severe pain, due to limited diagnostic/treatment management programmes. The development of objective clinical di
Autor:
Bethan, Young, John, Stephenson, Barira, Islam, Nikita N, Burke, Elaine M, Jennings, David P, Finn, Patrick C, McHugh
Publikováno v:
Molecular neurobiology.
Neuropathic pain is a common chronic condition, which remains poorly understood. Many patients receiving treatment continue to experience severe pain, due to limited diagnostic/treatment management programmes. The development of objective clinical di
Autor:
Laura Cano, Stefanie Mühlhausen, Laurence D. Hurst, Christine Mordstein, Samir F Watson, Bethan Young, Grzegorz Kudla, Atahualpa Castillo Morales, Alan M. Rice, Alexander T Ho
Publikováno v:
Morales, A C, Rice, A M, Ho, A T, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L D 2021, ' Causes and Consequences of Purifying Selection on SARS-CoV-2 ', Genome Biology and Evolution, vol. 13, no. 10, evab196 . https://doi.org/10.1093/gbe/evab196
Genome Biology and Evolution
Castillo Morales, A, Rice, A M, Ho, A, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L 2021, ' Causes and consequences of purifying selection on SARS-CoV-2 ', Genome biology and evolution, vol. 13, no. 10, evab196 . https://doi.org/10.1093/gbe/evab196
Genome Biology and Evolution
Castillo Morales, A, Rice, A M, Ho, A, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L 2021, ' Causes and consequences of purifying selection on SARS-CoV-2 ', Genome biology and evolution, vol. 13, no. 10, evab196 . https://doi.org/10.1093/gbe/evab196
Owing to a lag between a deleterious mutation’s appearance and its selective removal, gold-standard methods for mutation rate estimation assume no meaningful loss of mutations between parents and offspring. Indeed, from analysis of closely related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd602a3d5f8fd98dcf239820894a614
https://pure.au.dk/portal/da/publications/causes-and-consequences-of-purifying-selection-on-sarscov2(7200ed26-73da-49df-a3fc-ad0b99d452eb).html
https://pure.au.dk/portal/da/publications/causes-and-consequences-of-purifying-selection-on-sarscov2(7200ed26-73da-49df-a3fc-ad0b99d452eb).html
Autor:
Laura Cano, Christine Mordstein, Atahualpa Castillo Morales, Alan M. Rice, Alexander T Ho, Laurence D. Hurst, Grzegorz Kudla, Michael Liss, Bethan Young
Publikováno v:
Genome Biology and Evolution
Mordstein, C, Cano, L, Morales, A C, Young, B, Ho, A T, Rice, A M, Liss, M, Hurst, L D & Kudla, G 2021, ' Transcription, mRNA export, and immune evasion shape the codon usage of viruses ', Genome Biology and Evolution, vol. 13, no. 9, evab106 . https://doi.org/10.1093/gbe/evab106
Mordstein, C, Cano, L, Morales, A C, Young, B, Ho, A T, Rice, A M, Liss, M, Hurst, L D & Kudla, G 2021, ' Transcription, mRNA export, and immune evasion shape the codon usage of viruses ', Genome Biology and Evolution, vol. 13, no. 9, evab106 . https://doi.org/10.1093/gbe/evab106
The nucleotide composition, dinucleotide composition, and codon usage of many viruses differ from their hosts. These differences arise because viruses are subject to unique mutation and selection pressures that do not apply to host genomes; however,
Autor:
David A. Buckley, Barira Islam, Mark I. Johnson, Panagiotis Zis, Bethan Young, David P. Finn, Patrick C McHugh, Helen Radford, John Stephenson, Maurizio Manca
Publikováno v:
Neuromolecular medicine. 24(3)
In this study, we recruited 50 chronic pain (neuropathic and nociceptive) and 43 pain-free controls to identify specific blood biomarkers of chronic neuropathic pain (CNP). Affymetrix microarray was carried out on a subset of samples selected 10 CNP
Autor:
Christine Mordstein, Alexander T Ho, Laura Cano, Grzegorz Kudla, Atahualpa Castillo Morales, Alan M. Rice, Stephanie Mühlhausen, Laurence D. Hurst, Semir Watson, Bethan Young
Publikováno v:
Rice, A M, Castillo Morales, A, Ho, A T, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L D 2021, ' Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2 : Implications for Vaccine Design ', Molecular Biology and Evolution, vol. 38, no. 1, pp. 67-83 . https://doi.org/10.1093/molbev/msaa188
Molecular Biology and Evolution
Rice, A M, Morales, A C, Ho, A T, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L D 2021, ' Evidence for strong mutation bias towards, and selection against, U content in SARS-CoV-2: implications for vaccine design ', Molecular Biology and Evolution . https://doi.org/10.1093/molbev/msaa188
Molecular Biology and Evolution
Rice, A M, Morales, A C, Ho, A T, Mordstein, C, Mühlhausen, S, Watson, S, Cano, L, Young, B, Kudla, G & Hurst, L D 2021, ' Evidence for strong mutation bias towards, and selection against, U content in SARS-CoV-2: implications for vaccine design ', Molecular Biology and Evolution . https://doi.org/10.1093/molbev/msaa188
Large-scale re-engineering of synonymous sites is a promising strategy to generate vaccines either through synthesis of attenuated viruses or via codon-optimized genes in DNA vaccines. Attenuation typically relies on deoptimization of codon pairs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9eaad94072ae348262e6dd5ee8f79da
https://pure.au.dk/portal/da/publications/evidence-for-strong-mutation-bias-toward-and-selection-against-u-content-in-sarscov2(191a3952-ddab-4f97-a678-189bea2ed9a7).html
https://pure.au.dk/portal/da/publications/evidence-for-strong-mutation-bias-toward-and-selection-against-u-content-in-sarscov2(191a3952-ddab-4f97-a678-189bea2ed9a7).html
Autor:
Grzegorz Kudla, Liam Abrahams, Laurence D. Hurst, Rosina Savisaar, Bethan Young, Christine Mordstein
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Abrahams, L, Savisaar, R, Mordstein, C, Young, B, Kudla, G & Hurst, L D 2021, ' Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption ', Nucleic Acids Research, vol. 49, no. 17, pp. 9665-9685 . https://doi.org/10.1093/nar/gkab750
Nucleic Acids Research
Abrahams, L, Savisaar, R, Mordstein, C, Young, B, Kudla, G & Hurst, L 2021, ' Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption ', Nucleic Acids Research, vol. 49, no. 17, pp. 9665-9685 . https://doi.org/10.1093/nar/gkab750
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Abrahams, L, Savisaar, R, Mordstein, C, Young, B, Kudla, G & Hurst, L D 2021, ' Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption ', Nucleic Acids Research, vol. 49, no. 17, pp. 9665-9685 . https://doi.org/10.1093/nar/gkab750
Nucleic Acids Research
Abrahams, L, Savisaar, R, Mordstein, C, Young, B, Kudla, G & Hurst, L 2021, ' Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption ', Nucleic Acids Research, vol. 49, no. 17, pp. 9665-9685 . https://doi.org/10.1093/nar/gkab750
© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb41ee3aeb468d8ff8d56d0778369f68
https://hdl.handle.net/10451/49552
https://hdl.handle.net/10451/49552
Autor:
Samir F Watson, Alexander T Ho, Christine Mordstein, Laurence D. Hurst, Bethan Young, Stefanie Mühlhausen, Grzegorz Kudla, Atahualpa Castillo Morales, Alan M. Rice, Laura Cano
Large-scale re-engineering of synonymous sites is a promising strategy to generate attenuated viruses for vaccines. Attenuation typically relies on de-optimisation of codon pairs and maximization of CpG dinculeotide frequencies. So as to formulate ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521c7544cf0c5dac832ff1b90a491cc5
Autor:
Alexander T Ho, Stefanie Mühlhausen, Grzegorz Kudla, Bethan Young, Laura Cano, Christine Mordstein, Samir F Watson, Atahualpa Castillo Morales, Alan M. Rice, Laurence D. Hurst
Publikováno v:
Molecular Biology and Evolution
Large-scale re-engineering of synonymous sites is a promising strategy to generate vaccines either through synthesis of attenuated viruses or via codon-optimized genes in DNA vaccines. Attenuation typically relies on deoptimization of codon pairs and