Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Beth Wapelhorst"'
Autor:
Patrick Concannon, Beth Wapelhorst, Glenys Thomson, Ana M. Valdes, Henry A. Erlich, Janelle A. Noble
Publikováno v:
Tissue Antigens. 65:115-119
Human leukocyte antigen (HLA)-DR3 haplotypes are associated with susceptibility to type 1 diabetes (T1D). Reports from Northern European populations show that an allele (D6S273*2) at a microsatellite mapping to HLA class III marks an extended DR3-B18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f252f724722ffd85b3a80bd45e9b88
https://doi.org/10.1111/j.1399-0039.2005.00348.x
https://doi.org/10.1111/j.1399-0039.2005.00348.x
Autor:
V. Anne Morrison, Beth Wapelhorst, Lesya M. Pinchuk, John A. Todd, Nancy J. Cox, Patrick Concannon, Lindsey N. Johnson, Richard S. Spielman
Publikováno v:
The American Journal of Human Genetics. 69(4):820-830
Type 1 diabetes (T1D) is a genetically complex disorder of glucose homeostasis that results from the autoimmune destruction of the insulin-secreting cells of the pancreas. Two previous whole-genome scans for linkage to T1D in 187 and 356 families con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dcd1992af3a1e112c6bd0eabad7b8d
Publikováno v:
Molecular Genetics and Metabolism. 72:356-359
SOX13 is a member of the SOX family of transcription factors that encodes the type 1 diabetes autoantigen, ICA12. The SOX13 gene maps at chromosome 1q31.3-32.1 near a region containing a susceptibility locus for type 1 diabetes. SOX13 was assessed as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d91828344d5fbed112657d3450d70f
https://doi.org/10.1006/mgme.2000.3136
https://doi.org/10.1006/mgme.2000.3136
Autor:
J. Farmer, Richard S. Spielman, V. A. Morrison, David A. Hinds, Beth Wapelhorst, Patrick Concannon, Nancy J. Cox, B. Stirling, M. Mitra, S. R. Williams, K. J. Gogolin-Ewens, Graeme I. Bell, Neil Risch
Publikováno v:
Nature Genetics. 19:292-296
During the past decade, the genetics of type 1 (insulin-dependent) diabetes mellitus (IDDM) has been studied extensively and the disorder has become a paradigm for genetically complex diseases. Previous genome screens and studies focused on candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8448bede6f04a10cb3b9ba9d54c8a8
https://doi.org/10.1038/985
https://doi.org/10.1038/985
Autor:
Kristin O’Brien, Richard S. Spielman, Simon G. Gregory, Kathryn G. Ewens, Sarah A. Gutin, V. Anne Morrison, Beth Wapelhorst, Craig Street, Lindsey N. Johnson, Patrick Concannon
Publikováno v:
Diabetes. 51(11)
Type 1 diabetes is a complex disorder with multiple genetic loci and environmental factors contributing to disease etiology. In the current study, a human type 1 diabetes candidate region on chromosome 1q42 was mapped at high marker density in a pane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c54507259f40962cf38cfc0dbe2b71
https://pubmed.ncbi.nlm.nih.gov/12401725
https://pubmed.ncbi.nlm.nih.gov/12401725
Autor:
Hannes Rietzsch, Nancy J. Cox, Patrick Concannon, Graeme I. Bell, V. A. Morrison, L. E. Mereu, Darrell L. Ellsworth, J. M. Shephard, L. R. Lim, Beth Wapelhorst, S. R. Williams, Y. Yang, Tom H. Lindner, Makiko Ogata, Stephan Menzel, Eric Boerwinkle, X. Chen, B. Stirling, Jan Schulze, Hans Egbert Schröder, K S Xiang, Neil Risch, David A. Hinds, V. V. Boriraj, Ranajit Chakraborty, Craig L. Hanis, Naoko Iwasaki, C. Petzold, K. J. Gogolin-Ewens, Richard S. Spielman, Yasue Omori, Y. Q. Wang, Kazuya Yamagata
Publikováno v:
Nature genetics. 13(2)
Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899e63c7d0a4ce4198c9053d2ec885d3
https://pubmed.ncbi.nlm.nih.gov/9326932
https://pubmed.ncbi.nlm.nih.gov/9326932
Autor:
Graeme I. Bell, Patrick Concannon, Neil Risch, Richard S. Spielman, Rachel E. Rowe, Beth Wapelhorst
Publikováno v:
Nature genetics. 10(2)
Insulin-dependent diabetes mellitus (IDDM) is characterized by autoimmune destruction of the insulin secreting beta-cells of the pancreas and subsequent disruption of glucose metabolism. The tendency of IDDM to cluster in families and the modest (36%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6512c9819fd2b1f597c76b6dd8269417
https://pubmed.ncbi.nlm.nih.gov/7663523
https://pubmed.ncbi.nlm.nih.gov/7663523
Publikováno v:
Autoimmunity. 21(2)
Glutamic acid decarboxylase (GAD) is an important autoantigen in insulin-dependent diabetes mellitus (IDDM). The islet cell specific, 65 kDa form of GAD (GAD65) is encoded by a gene on chromosome 10p. Recently, a putative IDDM susceptibility gene has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2cc0b9571c59d9a0d5afe341b989a7
https://pubmed.ncbi.nlm.nih.gov/8679901
https://pubmed.ncbi.nlm.nih.gov/8679901