Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Beth S. Haggarty"'
1
Akademický článek
A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection.
Autor: Scott P Lawrence, Samra E Elser, Workineh Torben, Robert V Blair, Bapi Pahar, Pyone P Aye, Faith Schiro, Dawn Szeltner, Lara A Doyle-Meyers, Beth S Haggarty, Andrea P O Jordan, Josephine Romano, George J Leslie, Xavier Alvarez, David H O'Connor, Roger W Wiseman, Christine M Fennessey, Yuan Li, Michael Piatak, Jeffrey D Lifson, Celia C LaBranche, Andrew A Lackner, Brandon F Keele, Nicholas J Maness, Mark Marsh, James A Hoxie
Publikováno v: PLoS Pathogens, Vol 18, Iss 6, p e1010507 (2022)
The HIV/SIV envelope glycoprotein (Env) cytoplasmic domain contains a highly conserved Tyr-based trafficking signal that mediates both clathrin-dependent endocytosis and polarized sorting. Despite extensive analysis, the role of these functions in vi
Externí odkaz: https://doaj.org/article/d548a853acc4469fa6a4e1326a82b9a7
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2
Akademický článek
Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus.
Autor: George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Jennifer Duong, Anthony J Secreto, Andrea P O Jordon, Josephine Romano, Kritika E Kumar, Joshua J DeClercq, Philip D Gregory, Carl H June, Michael J Root, James L Riley, Michael C Holmes, James A Hoxie
Publikováno v: PLoS Pathogens, Vol 12, Iss 11, p e1005983 (2016)
HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and
Externí odkaz: https://doaj.org/article/b2848b8f422e4d1cb691aa0474392450
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4
Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus
Autor: Jianbin Wang, Josephine Romano, Beth S. Haggarty, Michael C. Holmes, James A. Hoxie, James L. Riley, Kevin Hua, Kritika E. Kumar, Andrea P. O. Jordon, George J. Leslie, Max W. Richardson, Philip D. Gregory, Anthony Secreto, Carl H. June, Jennifer Duong, Joshua J. DeClercq, Michael J. Root
Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 11, p e1005983 (2016)
HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347b289557740991009159ff95cf3e72
http://europepmc.org/articles/PMC5113989
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6
Distinct Molecular Pathways to X4 Tropism for a V3-Truncated Human Immunodeficiency Virus Type 1 Lead to Differential Coreceptor Interactions and Sensitivity to a CXCR4 Antagonist
Autor: Beth S. Haggarty, James A. Hoxie, George J. Leslie, Gregory Q. Del Prete, Josephine Romano, Andrea P. O. Jordan
Publikováno v: Journal of Virology. 84:8777-8789
During the course of infection, transmitted HIV-1 isolates that initially use CCR5 can acquire the ability to use CXCR4, which is associated with an accelerated progression to AIDS. Although this coreceptor switch is often associated with mutations i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dd0f66151342afa040feb4a6acb9f0
https://doi.org/10.1128/jvi.00333-10
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7
Differential N-Linked Glycosylation of Human Immunodeficiency Virus and Ebola Virus Envelope Glycoproteins Modulates Interactions with DC-SIGN and DC-SIGNR
Autor: Graham Simmons, George Lin, Frédéric Baribaud, Drew Weissman, Stefan Pöhlmann, Paul Bates, Beth S. Haggarty, George J. Leslie, James A. Hoxie, Houping Ni, Robert W. Doms
Publikováno v: Journal of Virology. 77:1337-1346
The C-type lectins DC-SIGN and DC-SIGNR [collectively referred to as DC-SIGN(R)] bind and transmit human immunodeficiency virus (HIV) and simian immunodeficiency virus to T cells via the viral envelope glycoprotein (Env). Other viruses containing hea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db8e83d298ffaf8e8d8733dcf41729d
https://doi.org/10.1128/jvi.77.2.1337-1346.2003
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8
Mutations in HIV-1 Envelope That Enhance Entry with the Macaque CD4 Receptor Alter Antibody Recognition by Disrupting Quaternary Interactions within the Trimer
Autor: David F. Boyd, Dylan Peterson, Michael J. Hogan, Andrea P. O. Jordan, Beth S. Haggarty, James A. Hoxie, Julie Overbaugh, Leslie Goo
Chimeric simian immunodeficiency virus (SIV)/human immunodeficiency virus (HIV) (SHIV) infection of macaques is commonly used to model HIV type 1 (HIV-1) transmission and pathogenesis in humans. Despite the fact that SHIVs encode SIV antagonists of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19d134d639b04c99c04735cf9c42093
https://europepmc.org/articles/PMC4300673/
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9
CD4-Independent Use of Rhesus CCR5 by Human Immunodeficiency Virus Type 2 Implicates an Electrostatic Interaction between the CCR5 N Terminus and the gp120 C4 Domain
Autor: Beth S. Haggarty, Robert W. Doms, James A. Hoxie, George Lin, Benhur Lee
Publikováno v: Journal of Virology. 75:10766-10778
Envelope glycoproteins (Envs) of human immunodeficiency virus type 2 (HIV-2) are frequently able to use chemokine receptors, CXCR4 or CCR5, in the absence of CD4. However, while these Envs are commonly dual-tropic, no isolate has been described to da
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a75f5b108daad80617eaf1bc3f8aca
https://doi.org/10.1128/jvi.75.22.10766-10778.2001
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10
Characterization and Epitope Mapping of Neutralizing Monoclonal Antibodies Produced by Immunization with Oligomeric Simian Immunodeficiency Virus Envelope Protein
Autor: Robert W. Doms, Ména Ahuja, James A. Hoxie, Kelly C. Baxter, Tina Sung, Aimee L. Edinger, Beth S. Haggarty
Publikováno v: Journal of Virology. 74:7922-7935
In an attempt to generate broadly cross-reactive, neutralizing monoclonal antibodies (MAbs) to simian immunodeficiency virus (SIV), we compared two immunization protocols using different preparations of oligomeric SIV envelope (Env) glycoproteins. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad136756e41d86781f6fe9dd009d3b11
https://doi.org/10.1128/jvi.74.17.7922-7935.2000
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