Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Beth S Lee"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87402 (2014)
Osteoclasts are large, multinucleated cells of the monocyte-macrophage lineage that generate specialized substrate adhesion complexes to facilitate their function as bone-degrading cells. The patterning and function of these actin-based complexes, po
Externí odkaz:
https://doaj.org/article/a64e5b61cc134caea953b2dcc20d98be
Autor:
Reeva Aggarwal, Jingwei Lu, Suman Kanji, Matthew Joseph, Manjusri Das, Garrett J Noble, Brooke K McMichael, Sudha Agarwal, Richard T Hart, Zongyang Sun, Beth S Lee, Thomas J Rosol, Rebecca Jackson, Hai-Quan Mao, Vincent J Pompili, Hiranmoy Das
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39365 (2012)
Osteoporosis is a bone disorder associated with loss of bone mineral density and micro architecture. A balance of osteoblasts and osteoclasts activities maintains bone homeostasis. Increased bone loss due to increased osteoclast and decreased osteobl
Externí odkaz:
https://doaj.org/article/9dc52b2d97a744c4b519d68f6ef9356c
The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli
Autor:
Beth S. Lee, Cynthia Murray, Jie Liu, Minji Kim, Min Sik Hwang, Tina Yueh, Myrna Mansour, Sana Qamar, Gunjan Agarwal, Do-Gyoon Kim
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Myosin IXB (MYO9B) is an unconventional myosin with RhoGAP activity and thus is a regulator of actin cytoskeletal organization. MYO9B was previously shown to be necessary for skeletal growth and health and to play a role in actin-based
Externí odkaz:
https://doaj.org/article/39d6f06a91de4b7cb2e431c0a07321d9
Autor:
Richard T. Clements, Radmila Terentyeva, Shanna Hamilton, Paul M. L. Janssen, Karim Roder, Benjamin Y. Martin, Fruzsina Perger, Timothy Schneider, Zuzana Nichtova, Anindhya S. Das, Roland Veress, Beth S. Lee, Do-Gyoon Kim, Gideon Koren, Matthew S. Stratton, Gyorgy Csordas, Federica Accornero, Andriy E. Belevych, Sandor Gyorke, Dmitry Terentyev
Publikováno v:
Basic Research in Cardiology. 118
Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca2+ release is essential to boost energy production in ventricular cardiomyocytes (VCMs) and match increased metabolic demand. Mitochondria from female hearts exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbc16c7193cf2b8cedadcf67efa7dafc
https://doi.org/10.1007/s00395-023-00988-1
https://doi.org/10.1007/s00395-023-00988-1
Autor:
Emily L. Durham, Zachary J. Grey, Laurel Black, R. Nicole Howie, Jeremy L. Barth, Beth S. Lee, James J. Cray
Publikováno v:
Life sciences. 311
Evidence suggests alterations of thyroid hormone levels can disrupt normal bone development. Most data suggest the major targets of thyroid hormones to be the Htra1/Igf1 pathway. Recent discovery by our group suggests involvement of targets WNT pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db9caa0ab42db702638f41de787c438
https://pubmed.ncbi.nlm.nih.gov/36370870
https://pubmed.ncbi.nlm.nih.gov/36370870
Publikováno v:
Bone. 163:116501
One-third of postmenopausal women experience at least one osteoporotic bone fracture in their lifetime that occurs spontaneously or from low-impact events. However, osteoporosis-associated jaw bone fractures are extremely rare. It was also observed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d449507aa29b3775ddc92dac3fcd18d
https://doi.org/10.1016/j.bone.2022.116501
https://doi.org/10.1016/j.bone.2022.116501
Autor:
Do-Gyoon Kim, Beth S. Lee, Toru Deguchi, Hongsik Cho, Anastasios Karydis, Fazal Ur Rehman Bhatti
Publikováno v:
Current osteoporosis reportsPapers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance. 19(2)
Many mechanical load-bearing joints of the body are prone to posttraumatic osteoarthritis (PTOA), including the knee joint and temporomandibular joint (TMJ). Early detection of PTOA can be beneficial in prevention or alleviating further progression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d10839a574f1489b25d6962e9e5451a
https://pubmed.ncbi.nlm.nih.gov/33523424
https://pubmed.ncbi.nlm.nih.gov/33523424
Publikováno v:
J Biomech
Estrogen deficiency activates bone resorbing cells (osteoclasts) and to a lesser extent bone forming cells (osteoblasts), resulting in a gap between resorption and formation that leads to a net loss of bone. These cell activities alter bone architect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f1ca11e76f79512d687d333ec2c38b
https://pubmed.ncbi.nlm.nih.gov/33915473
https://pubmed.ncbi.nlm.nih.gov/33915473
Autor:
Yong-Hoon Jeong, Beth S. Lee, Brooke K. McMichael, Martin Bähler, Kyle Bodnyk, Do-Gyoon Kim, Ryan Sedlar
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials. 84:99-107
The objective of this study was to examine relationships among a variety of bone characteristics, including volumetric, mineral density, geometric, dynamic mechanical analysis, and static fracture mechanical properties. As MYO9B is an unconventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c79707f2e9e2507163aeb8cead311c
https://doi.org/10.1016/j.jmbbm.2018.05.003
https://doi.org/10.1016/j.jmbbm.2018.05.003
Autor:
Beth S. Lee, Brooke K. McMichael, Ryan Sedlar, Justin A Auerbach, Do-Gyoon Kim, Sudha Agarwal, Martin Bähler, Yong-Hoon Jeong, Cheol-Min Han, Vikram Shettigar
Publikováno v:
Journal of Bone and Mineral Research. 32:2103-2115
The Ras homolog A (RhoA) subfamily of Rho guanosine triphosphatases (GTPases) regulates actin-based cellular functions in bone such as differentiation, migration, and mechanotransduction. Polymorphisms or genetic ablation of RHOA and some of its regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17e1124887b9a020fb3cc7380c70503
https://doi.org/10.1002/jbmr.3192
https://doi.org/10.1002/jbmr.3192