Výsledky vyhledávání

The Prognostic Biomarkers HOXB13, IL17BR, and CHDH Are Regulated by Estrogen in Breast Cancer

Autor: Heather Provencher, Beth Muir, Dennis C. Sgroi, Xiao-Jun Ma, Zuncai Wang, Toshi Shioda, Sonika Dahiya, Erin Carney, Kathryn R. Coser

Publikováno v: Clinical Cancer Research. 13:6327-6334

Purpose: We previously identified three genes, HOXB13, IL17BR, and CHDH, that strongly predict clinical outcome in estrogen receptor (ER)–positive breast cancer patients receiving tamoxifen monotherapy. The biological mechanisms linking these genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4a784ccb11519a043b50bbb94c9acf
https://doi.org/10.1158/1078-0432.ccr-07-0310

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A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors

Autor: Daniel A. Haber, Beth Muir, Benjamin J. Schott, Gromoslaw A. Smolen, Sven Diederichs, Dennis C. Sgroi, Rodney A. Stewart, A. Thomas Look, Randall T. Peterson, Heather Provencher

Publikováno v: Genes & Development. 21:2131-2136

The neural crest (NC) is a highly motile cell population that gives rise to multiple tissue lineages during vertebrate embryogenesis. Here, we identify a novel effector of the small GTPase Rap, called RADIL, and show that it is required for cell adhe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b18a84a4c2811f6fcedfb28b4653184
https://doi.org/10.1101/gad.1561507

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Synergism between NF-κB1/p50 and Notch2 during the Development of Marginal Zone B Lymphocytes

Autor: Beth Muir, Dennis C. Sgroi, Stewart T. Moran, Hao Yuan Liu, Shiv Pillai, Annaiah Cariappa, Cristian Boboila

Publikováno v: The Journal of Immunology. 179:195-200

NF-κB1 and Notch2 are both required for the development of marginal zone (MZ) B cells. Analysis of B lymphocyte development in mice that are doubly heterozygous at the Notch2 and NF-κB1 loci revealed synergism between Notch2 and NF-κB1 during MZ B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679efde59e18f43095cbdd0e6bfc33a3
https://doi.org/10.4049/jimmunol.179.1.195

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Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752

Autor: Dennis C. Sgroi, Anne Barmettler, Daphne W. Bell, Ross A. Okimoto, Beth Muir, Woo J. Kim, James G. Christensen, Gromoslaw A. Smolen, Raffaella Sordella, Heidi Archibald, Daniel A. Haber, Jeffrey Settleman, Gayatry Mohapatra

Publikováno v: Proceedings of the National Academy of Sciences. 103:2316-2321

The success of molecular targeted therapy in cancer may depend on the selection of appropriate tumor types whose survival depends on the drug target, so-called “oncogene addiction.” Preclinical approaches to defining drug-responsive subsets are n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d718b5bee33a3603f40a1b272d2b834c
https://doi.org/10.1073/pnas.0508776103

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Response of Some Head and Neck Cancers to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors May Be Linked to Mutation ofERBB2rather thanEGFR

Autor: Sonika Dahiya, Ezra E.W. Cohen, Daniel A. Haber, Everett E. Vokes, Ross A. Okimoto, John R. Clark, Patricia L. Harris, Brian W. Brannigan, Leslie E. Martin, Mark W. Lingen, Dennis C. Sgroi, Beth Muir, Daphne W. Bell, James W. Rocco, Sara M. Haserlat

Publikováno v: Clinical Cancer Research. 11:8105-8108

Purpose: Small-molecule tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) have shown modest yet reproducible response rates in patients with squamous cell carcinoma of the head and neck (SCCHN). Somatic mutations in EGFR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5aab774158002d53f1c8176296bd61
https://doi.org/10.1158/1078-0432.ccr-05-0926

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HOXB13 promotes ovarian cancer progression

Autor: Beth Muir, Sandra Orsulic, Chee-Onn Leong, Heather Provencher, Dennis C. Sgroi, Erin Carney, Zuncai Wang, Jiangyong Miao, Sonika Dahiya

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 104(43)

Deregulated expression of HOXB13 in a subset of estrogen receptor-positive breast cancer patients treated with tamoxifen monotherapy is associated with an aggressive clinical course and poor outcome. Because the ovary is another hormone-responsive or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff7d0f46210d581528b94738d6a3bad
https://pubmed.ncbi.nlm.nih.gov/17942676

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The Spemann organizer gene, Goosecoid, promotes tumor metastasis

Autor: Kimberly A. Hartwell, Dennis C. Sgroi, Robert A. Weinberg, Anne E. Carpenter, Ferenc Reinhardt, Beth Muir

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 103(50)

The process of invasion and metastasis during tumor progression is often reminiscent of cell migration events occurring during embryonic development. We hypothesized that genes controlling cellular changes in the Spemann organizer at gastrulation mig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c266f315c5d6ffaf6aeac91fe350f7b8
https://pubmed.ncbi.nlm.nih.gov/17142318

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