Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Beth Levine"'
Autor:
Jetsy Montero-Vergara, Kira Plachetta, Lisa Kinch, Stephan Bernhardt, Kriti Kashyap, Beth Levine, Lipi Thukral, Martina Vetter, Christoph Thomssen, Stefan Wiemann, Samuel Peña-Llopis, Verena Jendrossek, Silvia Vega-Rubin-de-Celis
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy t
Externí odkaz:
https://doaj.org/article/762fefe82a1e46f087b2a5cf64ad3261
Autor:
Muqing Cao, Xiaoxiao Zou, Chaoyi Li, Zaisheng Lin, Ni Wang, Zhongju Zou, Youqiong Ye, Joachim Seemann, Beth Levine, Zaiming Tang, Qing Zhong
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Dysfunction of cell cycle control and defects of primary ciliogenesis are two features of many cancers. Whether these events are interconnected and the driving mechanism coordinating them remains elusive. Here, we identify an actin filament
Externí odkaz:
https://doaj.org/article/5a4e7b718e5d4006ac84d208fd7b4f6c
Autor:
Muqing Cao, Xiaoxiao Zou, Chaoyi Li, Zaisheng Lin, Ni Wang, Zhongju Zou, Youqiong Ye, Joachim Seemann, Beth Levine, Zaiming Tang, Qing Zhong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/4b6f113d046c4d62bdde598209ce488f
Autor:
Phong T. Nguyen, Christine Deisl, Michael Fine, Trevor S. Tippetts, Emiko Uchikawa, Xiao-chen Bai, Beth Levine
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Through cryo-EM analysis, here authors reveal conformational rearrangements that are critical for the gating mechanism of the human alpha3 Na+/K+−ATPase
Externí odkaz:
https://doaj.org/article/76b7117e2923402c8fc3c834dd1be515
Autor:
Zhenzhen Zi, Zhuzhen Zhang, Qiang Feng, Chiho Kim, Xu-Dong Wang, Philipp E. Scherer, Jinming Gao, Beth Levine, Yonghao Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
mTORC1, central regulator of cell growth and autophagy suppressor, is activated on the lysosome surface, but its local role in lysosomal biology remains unclear. Here the authors show STK11IP is a substrate of mTORC1 that regulates lysosomal acidific
Externí odkaz:
https://doaj.org/article/b73a4c77238140d09f96cfc934dc20ef
Publikováno v:
Hepatology Communications, Vol 3, Iss 11, Pp 1450-1458 (2019)
Excessive accumulation of lipids in the liver is crucial in the pathogenesis of alcoholic steatohepatitis and may be partly mediated by impaired degradation of lipid droplets by autophagy. The E3 ubiquitin ligase SMAD‐specific E3 ubiquitin protein
Externí odkaz:
https://doaj.org/article/ec6c5619e2234b2abf92657ccd04b1ac
Autor:
Ramesh B. Kasetti, Prabhavathi Maddineni, Charles Kiehlbauch, Shruti Patil, Charles C. Searby, Beth Levine, Val C. Sheffield, Gulab S. Zode
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Elevation of intraocular pressure (IOP) due to trabecular meshwork (TM) damage is associated with primary open-angle glaucoma (POAG). Myocilin mutations resulting in elevated IOP are the most common genetic causes of POAG. We have previously shown th
Externí odkaz:
https://doaj.org/article/d48f0fd972a04d0db0dea25165c012ca
Autor:
Fernando G. Vieira, Theo Hatzipetros, Kenneth Thompson, Andy J. Moreno, Joshua D. Kidd, Valerie R. Tassinari, Beth Levine, Steven Perrin, Alan Gill
Publikováno v:
IBRO Reports, Vol 2, Iss C, Pp 47-53 (2017)
A copper chelator known as diacetylbis(N(4)-methylthiosemicarbazonato) copper II (CuATSM), has been reported to be efficacious in multiple transgenic SOD1 models of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting mot
Externí odkaz:
https://doaj.org/article/246f87e177af4a04ac08f48d41cbc051
Autor:
Vidhya R. Nair, Luis H. Franco, Vineetha M. Zacharia, Haaris S. Khan, Chelsea E. Stamm, Wu You, Denise K. Marciano, Hideo Yagita, Beth Levine, Michael U. Shiloh
Publikováno v:
Cell Reports, Vol 16, Iss 5, Pp 1253-1258 (2016)
The prevailing paradigm is that tuberculosis infection is initiated when patrolling alveolar macrophages and dendritic cells within the terminal alveolus ingest inhaled Mycobacterium tuberculosis (Mtb). However, definitive data for this model are lac
Externí odkaz:
https://doaj.org/article/ad22e38945ad49b0a84e9a1b41892893
Autor:
Hao Tang, Salwa Sebti, Rossella Titone, Yunyun Zhou, Ciro Isidoro, Theodora S. Ross, Hanina Hibshoosh, Guanghua Xiao, Milton Packer, Yang Xie, Beth Levine
Publikováno v:
EBioMedicine, Vol 2, Iss 3, Pp 255-263 (2015)
Both BRCA1 and Beclin 1 (BECN1) are tumor suppressor genes, which are in close proximity on the human chromosome 17q21 breast cancer tumor susceptibility locus and are often concurrently deleted. However, their importance in sporadic human breast can
Externí odkaz:
https://doaj.org/article/61c0e5751840485da3f3e0231949ad8f