Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Beth K Martin"'
Autor:
Florence M. Chardon, Troy A. McDiarmid, Nicholas F. Page, Riza M. Daza, Beth K. Martin, Silvia Domcke, Samuel G. Regalado, Jean-Benoît Lalanne, Diego Calderon, Xiaoyi Li, Lea M. Starita, Stephan J. Sanders, Nadav Ahituv, Jay Shendure
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CRISPR-based gene activation (CRISPRa) is a strategy for upregulating gene expression by targeting promoters or enhancers in a tissue/cell-type specific manner. Here, we describe an experimental framework that combines highly multiplexed per
Externí odkaz:
https://doaj.org/article/9bd7fc937a4c4d249a6334bbcbf59eb9
Autor:
Jan Rehker, Johanna Rodhe, Ryan R Nesbitt, Evan A Boyle, Beth K Martin, Jenny Lord, Ilker Karaca, Adam Naj, Frank Jessen, Seppo Helisalmi, Hilkka Soininen, Mikko Hiltunen, Alfredo Ramirez, Martin Scherer, Lindsay A Farrer, Jonathan L Haines, Margaret A Pericak-Vance, Wendy H Raskind, Carlos Cruchaga, Gerard D Schellenberg, Bertrand Joseph, Zoran Brkanac
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185777 (2017)
The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage product, is a leading hypothesis in the etiology of Alzheimer's disease (AD). In order to identify additional AD risk genes, we performed targeted se
Externí odkaz:
https://doaj.org/article/56a02bfc424f407eaf9e982c96880b2c
Autor:
David F. Read, Gregory T. Booth, Riza M. Daza, Dana L. Jackson, Rula Green Gladden, Sanjay R. Srivatsan, Brent Ewing, Jennifer M. Franks, Cailyn H. Spurrell, Anne Roshella Gomes, Diana O’Day, Aishwarya A. Gogate, Beth K. Martin, Haleigh Larson, Christian Pfleger, Lea Starita, Yiing Lin, Jay Shendure, Shin Lin, Cole Trapnell
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types v
Externí odkaz:
https://doaj.org/article/c78d59de759c46328c8bc8b520ab680e
Autor:
Jill M. Johnsen, Shelley N. Fletcher, Angela Dove, Haley McCracken, Beth K. Martin, Martin Kircher, Neil C. Josephson, Jay Shendure, Sarah E. Ruuska, Leonard A. Valentino, Glenn F. Pierce, Crystal Watson, Dunlei Cheng, Michael Recht, Barbara A. Konkle
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2022-2034
Hemophilia A (HA) and hemophilia B (HB) are rare inherited bleeding disorders. Although causative genetic variants are clinically relevant, in 2012 only 20% of US patients had been genotyped.My Life, Our Future (MLOF) was a multisector cross-sectiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd83930bf42172f5f590a617c4039729
https://doi.org/10.1111/jth.15805
https://doi.org/10.1111/jth.15805
Autor:
Jill M. Johnsen, Shelley N. Fletcher, Haley Huston, Sarah Roberge, Beth K. Martin, Martin Kircher, Neil C. Josephson, Jay Shendure, Sarah Ruuska, Marion A. Koerper, Jaime Morales, Glenn F. Pierce, Diane J. Aschman, Barbara A. Konkle
Publikováno v:
Blood Advances, Vol 1, Iss 13, Pp 824-834 (2017)
Abstract: Hemophilia A and B are rare, X-linked bleeding disorders. My Life, Our Future (MLOF) is a collaborative project established to genotype and study hemophilia. Patients were enrolled at US hemophilia treatment centers (HTCs). Genotyping was p
Externí odkaz:
https://doaj.org/article/5eead2a944f548ea9aa455c5466a5ad6
Autor:
Xiaoyi Li, Wei Chen, Beth K. Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy McDiarmid, Haedong Kim, Jean-Benoît Lalanne, Jenny F. Nathans, Jay Shendure
Publikováno v:
bioRxiv
Prime editing is a powerful means of introducing precise changes to specific locations in mammalian genomes. However, the widely varying efficiency of prime editing across target sites of interest has limited its adoption in the context of both basic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c905bcb9d87e0305187017c68bc9730
https://europepmc.org/articles/PMC10120711/
https://europepmc.org/articles/PMC10120711/
Autor:
Chengxiang Qiu, Beth K. Martin, Ian C. Welsh, Riza M. Daza, Truc-Mai Le, Xingfan Huang, Eva K. Nichols, Megan L. Taylor, Olivia Fulton, Diana R. O’Day, Anne Roshella Gomes, Saskia Ilcisin, Sanjay Srivatsan, Xinxian Deng, Christine M. Disteche, William Stafford Noble, Nobuhiko Hamazaki, Cecilia B. Moens, David Kimelman, Junyue Cao, Alexander F. Schier, Malte Spielmann, Stephen A. Murray, Cole Trapnell, Jay Shendure
The house mouse,Mus musculus, is an exceptional model system, combining genetic tractability with close homology to human biology. Gestation in mouse development lasts just under three weeks, a period during which its genome orchestrates the astonish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6adc05866263a01873e739f8b89c8a3e
https://doi.org/10.1101/2023.04.05.535726
https://doi.org/10.1101/2023.04.05.535726
Autor:
Vikram Agarwal, Fumitaka Inoue, Max Schubach, Beth K. Martin, Pyaree Mohan Dash, Zicong Zhang, Ajuni Sohota, William Stafford Noble, Galip Gürkan Yardimci, Martin Kircher, Jay Shendure, Nadav Ahituv
The human genome contains millions of candidatecis-regulatory elements (CREs) with cell-type-specific activities that shape both health and myriad disease states. However, we lack a functional understanding of the sequence features that control the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a99ec33d6351a2b50cc1f617702fb8
https://doi.org/10.1101/2023.03.05.531189
https://doi.org/10.1101/2023.03.05.531189
Autor:
Chengxiang Qiu, Junyue Cao, Beth K. Martin, Tony Li, Ian C. Welsh, Sanjay Srivatsan, Xingfan Huang, Diego Calderon, William Stafford Noble, Christine M. Disteche, Stephen A. Murray, Malte Spielmann, Cecilia B. Moens, Cole Trapnell, Jay Shendure
Publikováno v:
Nature Genetics. 54:328-341
Mammalian embryogenesis is characterized by rapid cellular proliferation and diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells expressing a panoply of molecular programs. Although intensively studied, a compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff34ba3234eabac15117211d92b6b80
https://doi.org/10.1038/s41588-022-01018-x
https://doi.org/10.1038/s41588-022-01018-x
Autor:
Gianluca Amadei, Charlotte E. Handford, Chengxiang Qiu, Joachim De Jonghe, Hannah Greenfeld, Martin Tran, Beth K. Martin, Dong-Yuan Chen, Alejandro Aguilera-Castrejon, Jacob H. Hanna, Michael B. Elowitz, Florian Hollfelder, Jay Shendure, David M. Glover, Magdalena Zernicka-Goetz
Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in vitro1–5, but their developmental potential is substantially extended by interactions with extraembryonic stem cells, including trophoblast stem (TS) cells, extraembry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41f27ede82df3fe7402f34c678cf5ff
https://resolver.caltech.edu/CaltechAUTHORS:20221010-454096500.25
https://resolver.caltech.edu/CaltechAUTHORS:20221010-454096500.25