Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Beth Garvy"'
Autor:
Sagar S. Matharu, Cassidy S. Nordmann, Kurtis R. Ottman, Rahul Akkem, Douglas Palumbo, Denzel R. D. Cruz, Kenneth Campbell, Gail Sievert, Jamie Sturgill, James Z. Porterfield, Smita Joshi, Hammodah R. Alfar, Chi Peng, Irina D. Pokrovskaya, Jeffrey A. Kamykowski, Jeremy P. Wood, Beth Garvy, Maria A. Aronova, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
AbstractPlatelets contribute to COVID-19 clinical manifestations, of which microclotting in the pulmonary vasculature has been a prominent symptom. To investigate the potential diagnostic contributions of overall platelet morphology and their α-gran
Externí odkaz:
https://doaj.org/article/568668bf99a4473e9c0e48d15d0ffc3d
Autor:
Heather Evans, Beth Garvy
Publikováno v:
The Journal of Immunology. 194:63.5-63.5
Pneumocystis species are opportunistic fungal pathogens that cause severe pneumonia in immunocompromised hosts. The life cycle of Pneumocystis species consists of a trophic stage and ascus-like cysts. Our lab has published data demonstrating that cys
Autor:
Heather Evans, Beth Garvy
Publikováno v:
The Journal of Immunology. 192:132.14-132.14
Pneumocystis species are opportunistic fungal pathogens that cause severe pneumonia in immunocompromised hosts. The life cycle of Pneumocystis species consists of a vegetative trophic stage and an ascus-like cystic stage. We demonstrate that infectio
Publikováno v:
The Journal of Immunology. 188:68.11-68.11
Age-associated defects in innate immunity have a role in reduced immunity and vaccine efficacy to many Gram positive bacteria like Streptococcus pneumoniae . We have previously shown that splenic macrophages from aged mice exhibited a cytokine dysreg
Autor:
Michael Opata, Beth Garvy
Publikováno v:
The Journal of Immunology. 186:99.3-99.3
Host defense against the opportunistic fungal pathogen Pneumocystis (Pc) is dependent upon T cells, B cells and TNFα. Preliminary studies from our laboratory have demonstrated that CD4 T cells undergo increased apoptosis in the absence of B cells su
Publikováno v:
The Journal of Immunology. 186:49.23-49.23
T cells in the neonatal lung are less activated than in adults and do not infiltrate the alveolar spaces in response to influenza virus infection. TGFβ is elevated in the lungs of neonatal mice, and since neonatal mice do not respond with a typical
Publikováno v:
The Journal of Immunology. 186:56.10-56.10
Postnatal lung development renders a different lung environment and composition in neonates as compared to adults, making the neonatal immune response to lung pathogens, such as Pneumocystis (PC), less efficient than adults. Alveolar macrophages (AMs
Publikováno v:
The Journal of Immunology. 184:137.6-137.6
Influenza virus is responsible for more infant hospitalizations and deaths than any other vaccine preventable disease in America. Our laboratory has established a neonatal murine model to influenza and have reported that T cells in the neonatal lung
Publikováno v:
The Journal of Immunology. 184:40.6-40.6
Lymphocyte and TNF deficiency leads to susceptibility to opportunistic infections such as Pneumocystis carinii (PC). This strongly indicates that protection against the fungal pathogen PC is dependent upon B cells, T cells and TNF. Although it has be
Publikováno v:
The Journal of Immunology. 184:37.7-37.7
Neonates are unable to clear Pneumocystis (PC) infection with the same efficiency as adults. The alveolar macrophage (AM) phenotype of neonates during infection varies from that of adults, leading to a delayed inflammatory response and a slower clear