Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Beth E. Zucconi"'
Autor:
Jayme L. Dahlin, Bruce K. Hua, Beth E. Zucconi, Shawn D. Nelson, Shantanu Singh, Anne E. Carpenter, Jonathan H. Shrimp, Evelyne Lima-Fernandes, Mathias J. Wawer, Lawrence P. W. Chung, Ayushi Agrawal, Mary O’Reilly, Dalia Barsyte-Lovejoy, Magdalena Szewczyk, Fengling Li, Parnian Lak, Matthew Cuellar, Philip A. Cole, Jordan L. Meier, Tim Thomas, Jonathan B. Baell, Peter J. Brown, Michael A. Walters, Paul A. Clemons, Stuart L. Schreiber, Bridget K. Wagner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Cellular nuisance compounds are a burden in chemical biology and drug screening. Here the authors profile prototypical cytotoxic and nuisance compounds using the cell painting assay to systematically characterise cellular morphologies associated with
Externí odkaz:
https://doaj.org/article/a0652f03d5554808827f7867140b6ae5
Autor:
Na Man, Gloria Mas, Daniel L. Karl, Jun Sun, Fan Liu, Qin Yang, Miguel Torres-Martin, Hidehiro Itonaga, Concepcion Martinez, Shi Chen, Ye Xu, Stephanie Duffort, Pierre-Jacques Hamard, Chuan Chen, Beth E. Zucconi, Luisa Cimmino, Feng-Chun Yang, Mingjiang Xu, Philip A. Cole, Maria E. Figueroa, Stephen D. Nimer
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis and an increased risk of leukemia transformation. Epigenetic regulators are recurrently mutated in MDS, directly
Externí odkaz:
https://doaj.org/article/da3ffac6658646129e6aad70db2c0b9e
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma that is driven by the BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin through its two bromodomains, and NUT recruits the p300 histone acetyltransfers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443954089c12bc613ff9662283e9aeac
https://doi.org/10.1158/1535-7163.c.6542821.v1
https://doi.org/10.1158/1535-7163.c.6542821.v1
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
Supplemental Table S1. Statistical analysis of survival in PER-403 model, full study. Supplemental Table S2. Statistical analysis of survival in 10-15 mouse model, full study. Supplemental Table S3. Statistical analysis of survival in 14169 model, fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ce5c6c0f1f31ef00393d18c6eef31b
https://doi.org/10.1158/1535-7163.22520881.v1
https://doi.org/10.1158/1535-7163.22520881.v1
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
Supplemental Figure S1: NEO2734 induces differentiation in 10-15 cells. Supplemental Figure S2: Caspase-mediated apoptosis plays a minimal role in the activity of GNE-781, OTX015, or NEO2734. Supplemental Figure S3: BRD4-NUT protein levels decrease s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a1f4894b3d5165744e623dd4428b44
https://doi.org/10.1158/1535-7163.22520908.v1
https://doi.org/10.1158/1535-7163.22520908.v1
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6ffe4170e4aef0664906df6b39bbf0
https://doi.org/10.1158/1535-7163.22520902
https://doi.org/10.1158/1535-7163.22520902
Autor:
Christopher A. French, Madeleine E. Lemieux, Philip A. Cole, Beth E. Zucconi, Geoffrey I. Shapiro, Bill Brown, Andrew Griffin, Francis Giles, Prafulla C. Gokhale, Margaret K. Wilkens, Benjamin K. Eschle, Kara M. Soroko, Ivona Filic, Tatiana M. Knox, Chevaun D. Morrison-Smith
Supplemental methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbe62cc2bffe5c35fe4144d12b0bef5
https://doi.org/10.1158/1535-7163.22520890.v1
https://doi.org/10.1158/1535-7163.22520890.v1
Autor:
Rhoda M. Alani, Philip A. Cole, Byungwoo Ryu, Estela C. Gonzalez, Daniel L. Cohen, Samantha Venkatesh, Jean S. McGee, David J. Meyers, Sarah E. Nocco, Muzhou Wu, Beth E. Zucconi, Edward Kim
Histone modifications, largely regulated by histone acetyltransferases (HAT) and histone deacetylases, have been recognized as major regulatory mechanisms governing human diseases, including cancer. Despite significant effort and recent advances, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89fb2708cd78bddcdd533eec1061a73f
https://doi.org/10.1158/0008-5472.c.6510288.v1
https://doi.org/10.1158/0008-5472.c.6510288.v1
Autor:
Rhoda M. Alani, Philip A. Cole, Byungwoo Ryu, Estela C. Gonzalez, Daniel L. Cohen, Samantha Venkatesh, Jean S. McGee, David J. Meyers, Sarah E. Nocco, Muzhou Wu, Beth E. Zucconi, Edward Kim
Figures S1-S5 and Table S1. Supplementary Figure S1. p300 depletion and phenotype analysis in melanoma cell lines. Supplementary Figure S2. Molecular pathways associated with p300 in melanoma. Supplementary Figure S3. MITF is essential for melanoma s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c511af103d82b3d9d30451a938124db
https://doi.org/10.1158/0008-5472.22419093.v1
https://doi.org/10.1158/0008-5472.22419093.v1
Autor:
Bill Brown, Griffin Andrew, Chevaun Morrison-Smith, Christopher A. French, Ivona Filic, Francis J. Giles, Kara M. Soroko, Beth E. Zucconi, Philip A. Cole, Benjamin K. Eschle, Margaret K. Wilkens, Madeleine E. Lemieux, Tatiana M. Knox, Prafulla C. Gokhale, Geoffrey I. Shapiro
Publikováno v:
Molecular Cancer Therapeutics. 19:1406-1414
NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma that is driven by the BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin through its two bromodomains, and NUT recruits the p300 histone acetyltransfers