Impairment of early fracture healing by skeletal muscle trauma is restored by FK506

Autor: Brady J. Hurtgen, Beth E. P. Henderson, Catherine L. Ward, Stephen M. Goldman, Koyal Garg, Todd O. McKinley, Sarah M. Greising, Joseph C. Wenke, Benjamin T. Corona

Publikováno v: BMC Musculoskeletal Disorders, Vol 18, Iss 1, Pp 1-10 (2017)

Abstract Background Heightened local inflammation due to muscle trauma or disease is associated with impaired bone regeneration. Methods We hypothesized that FK506, an FDA approved immunomodulatory compound with neurotrophic and osteogenic effects, w

Externí odkaz: https://doaj.org/article/570010e9adb24db2a099b870d368567a

Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.

Autor: Martine Manuel, Kai Boon Tan, Zrinko Kozic, Michael Molinek, Tiago Sena Marcos, Maizatul Fazilah Abd Razak, Dániel Dobolyi, Ross Dobie, Beth E P Henderson, Neil C Henderson, Wai Kit Chan, Michael I Daw, John O Mason, David J Price

Publikováno v: PLoS Biology, Vol 20, Iss 9, p e3001563 (2022)

The development of stable specialized cell types in multicellular organisms relies on mechanisms controlling inductive intercellular signals and the competence of cells to respond to such signals. In developing cerebral cortex, progenitors generate o

Externí odkaz: https://doaj.org/article/e095303f3e8640019b40c0c448f676c2

Single-cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs

Autor: Beth E. P. Henderson, Lesley M. Forrester, Katrin Ottersbach, Nicola Romanò, Jennifer Easterbrook, Alexander Medvinsky, Patrick S. Stumpf, Antonella Fidanza, Sara Tamagno, Martha Lopez-Yrigoyen, Prakash Ramachandran, Neil C. Henderson, Ann C. Babtie, Richard A Axton, A. Helen Taylor

Publikováno v: Blood
Fidanza, A, Stumpf, P S, Ramachandran, P, Tamagno, S, Babtie, A, Lopez Yrigoyen, M, Taylor, H, Easterbrook, J, Henderson, B, Axton, R, Henderson, N C, Medvinsky, A, Ottersbach, K, Romanò, N & Forrester, L 2020, ' Single cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs ', Blood, vol. 136, no. 25, pp. 2893–2904 . https://doi.org/10.1182/blood.2020006229

Hematopoietic stem and progenitor cells (HSPCs) develop in distinct waves at various anatomical sites during embryonic development. The in vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates some of these processes; however, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a39c42dec94b998de99ce4b6db62471
https://doi.org/10.1182/blood.2020006229

Resolving the fibrotic niche of human liver cirrhosis at single cell level

Autor: Mirjana Efremova, Ross Dobie, Jonathan A. Fallowfield, Prakash Ramachandran, Stephen J. Wigmore, John P. Iredale, Ewen M Harrison, Kylie P. Matchett, John C. Marioni, David R. Mole, Christopher J. Weston, John A. Marwick, John R. Wilson-Kanamori, Roser Vento-Tormo, Philip N. Newsome, Sarah A. Teichmann, Neil C. Henderson, Neil O. Carragher, Richard S Taylor, Jordan R. Portman, Elena Dora, N T Luu, Frank Tacke, Chris P. Ponting, Jeffrey W. Pollard, Beth E. P. Henderson, Timothy J. Kendall, M Brice

Publikováno v: Nature
Ramachandran, P, Dobie, R, Wilson-Kanamori, J R, Dora, E F, Henderson, B E P, Luu, N T, Portman, J R, Matchett, K P, Brice, M, Marwick, J A, Taylor, R S, Efremova, M, Vento-Tormo, R, Carragher, N O, Kendall, T J, Fallowfield, J A, Harrison, E M, Mole, D J, Wigmore, S J, Newsome, P N, Weston, C J, Iredale, J P, Tacke, F, Pollard, J W, Ponting, C P, Marioni, J C, Teichmann, S A & Henderson, N C 2019, ' Resolving the fibrotic niche of human liver cirrhosis at single-cell level ', Nature, vol. 575, no. 7783, pp. 512–518 . https://doi.org/10.1038/s41586-019-1631-3

Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3362c457a2a6d54f3fadf6498190b2
http://europepmc.org/articles/PMC6876711

A Unique Macrophage Subpopulation Signals Directly to Progenitor Cells to Promote Regenerative Neurogenesis in the Zebrafish Spinal Cord

Autor: Ana-Maria Oprişoreanu, Leonardo Cavone, Neil C. Henderson, Soe Sandi, Marcus Keatinge, Thomas Becker, Beth E. P. Henderson, Erika A. Aguzzi, Themistoklis M. Tsarouchas, Daniel Wehner, Tess McCann, Louisa K. Drake, Jathurshan Selvarajah, Elisa Pedersen, Catherina G. Becker, Ross Dobie

Publikováno v: SSRN Electronic Journal.

During ontogeny, neural stem cells in the spinal cord cease production of neurons. Spinal cord injury re-initiates neurogenesis in anamniotes (amphibians and fishes), but not in mammals. It is unclear whether regenerative neurogenesis from spinal pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20f929dd242911c3c7656968d0fd0e13
https://doi.org/10.2139/ssrn.3712669