Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Beth E. Helgeson"'
Autor:
Scott A. Tomlins, Bharathi Laxman, Sooryanarayana Varambally, Xuhong Cao, Jindan Yu, Beth E. Helgeson, Qi Cao, John R. Prensner, Mark A. Rubin, Rajal B. Shah, Rohit Mehra, Arul M. Chinnaiyan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 2, Pp 177-188 (2008)
TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer. Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo model systems. Transgenic mice expressing the ERG gene fusion product under an
Externí odkaz:
https://doaj.org/article/ae9ecd31530d4fb6b1bb7f218f8c8672
Autor:
Bharathi Laxman, Scott A. Tomlins, Rohit Mehra, David S. Morris, Lei Wang, Beth E. Helgeson, Rajal B. Shah, Mark A. Rubin, John T. Wei, Arul M. Chinnaiyan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 10, Pp 885-888 (2006)
We recently reported the identification of recurrent gene fusions in the majority of prostate cancers involving the 5V untranslated region of the androgenregulated gene TMPRSS2, the ETS family members ERG, ETV1, ETV4. Here we report the noninvasive d
Externí odkaz:
https://doaj.org/article/1b68568bb819467bac6bf6680069c755
Autor:
Arul M. Chinnaiyan, Rohit Mehra, Sooryanarayana Varambally, James E. Montie, Nirmish Singla, Xuhong Cao, John R. Prensner, Qi Cao, Bharathi Laxman, Nameeta Shah, Scott A. Tomlins, Beth E. Helgeson
Supplementary Figures 1-2, Tables 1-2 from Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c6f1295061352ce4f197619ac75778
https://doi.org/10.1158/0008-5472.22370561.v1
https://doi.org/10.1158/0008-5472.22370561.v1
Autor:
Arul M. Chinnaiyan, Rohit Mehra, Sooryanarayana Varambally, James E. Montie, Nirmish Singla, Xuhong Cao, John R. Prensner, Qi Cao, Bharathi Laxman, Nameeta Shah, Scott A. Tomlins, Beth E. Helgeson
Recurrent gene fusions involving oncogenic ETS transcription factors (including ERG, ETV1, and ETV4) have been identified in a large fraction of prostate cancers. The most common fusions contain the 5′ untranslated region of TMPRSS2 fused to ERG. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4549e44a13fdcc290c38f5edf0d031
https://doi.org/10.1158/0008-5472.c.6496433
https://doi.org/10.1158/0008-5472.c.6496433
Autor:
Hikmat Al-Ahmadie, Daniel R. Rhodes, Sven Perner, David S. Morris, John T. Wei, Laura A. Johnson, Rohit Mehra, Victor E. Reuter, Bharathi Laxman, P.W. Kantoff, Rajal B. Shah, Mark A. Rubin, Arul M. Chinnaiyan, Katja Fall, Samson W. Fine, Kristina Hotakainen, Alexander Tsodikov, Hans Lilja, Scott A. Tomlins, Francesca Demichelis, Qi Cao, Sooryanarayana Varambally, William L. Gerald, Xuhong Cao, Peter T. Scardino, Ove Andrén, Jianjun Yu, Anders Bjartell, James A. Eastham, Scott E. Eggener, Beth E. Helgeson, Ulf-Håkan Stenman
Publikováno v:
Cancer Cell. 13:519-528
ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusivel
Autor:
Arul M. Chinnaiyan, Rohit Mehra, Scott A. Tomlins, Beth E. Helgeson, Xuhong Cao, Nameeta Shah, John R. Prensner, James E. Montie, Qi Cao, Sooryanarayana Varambally, Bharathi Laxman, Nirmish Singla
Publikováno v:
Cancer Research. 68:73-80
Recurrent gene fusions involving oncogenic ETS transcription factors (including ERG, ETV1, and ETV4) have been identified in a large fraction of prostate cancers. The most common fusions contain the 5′ untranslated region of TMPRSS2 fused to ERG. R
Autor:
Lei Wang, Xiaojun Jing, Rajal B. Shah, Bo Han, Bharathi Laxman, Xuhong Cao, Beth E. Helgeson, Rohit Mehra, Arul M. Chinnaiyan, Jindan Yu, Scott A. Tomlins, Qi Cao, Kenneth J. Pienta, Sooryanarayana Varambally, James E. Montie, Anjana Menon, Saravana M. Dhanasekaran, David S. Morris, Mark A. Rubin, Diane Roulston
Publikováno v:
Nature. 448:595-599
Recently, we identified recurrent gene fusions involving the 5' untranslated region of the androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family genes ERG, ETV1 or ETV4 in most prostate cancers. Whereas TMPRSS2-ERG fusions
Autor:
Rajal B. Shah, David S. Morris, Lei Wang, Bharathi Laxman, Scott A. Tomlins, John T. Wei, Mark A. Rubin, Beth E. Helgeson, Rohit Mehra, Arul M. Chinnaiyan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 10, Pp 885-888 (2006)
We recently reported the identification of recurrent gene fusions in the majority of prostate cancers involving the 5' untranslated region of the androgen-regulated gene TMPRSS2 and the ETS family members ERG, ETV1, and ETV4. Here we report the nonin
Autor:
Beth E. Helgeson, Daniel R. Rhodes, Arul M. Chinnaiyan, Bushra Ateeq, Qi Cao, Rohit Mehra, Sooryanarayana Varambally, Peter C. Lucas, Scott A. Tomlins, Celina G. Kleer, Mahaveer S. Bhojani, Alnawaz Rehemtulla, Shanker Kalyana-Sundaram, Bharathi Laxman, Robert J. Lonigro, Daniel F. Hayes
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(25)
Breast cancer patients have benefited from the use of targeted therapies directed at specific molecular alterations. To identify additional opportunities for targeted therapy, we searched for genes with marked overexpression in subsets of tumors acro
Autor:
Xuhong Cao, John T. Wei, Mark A. Rubin, Beth E. Helgeson, Diane Roulston, Rajal B. Shah, Lisa Smith, Rohit Mehra, Scott A. Tomlins, Arul M. Chinnaiyan, Daniel R. Rhodes
Publikováno v:
Cancer research. 66(7)
Although common in hematologic and mesenchymal malignancies, recurrent gene fusions have not been well characterized in epithelial carcinomas. Recently, using a novel bioinformatic approach, we identified recurrent gene fusions between TMPRSS2 and th