Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Beth D, Youngblood"'
Autor:
John R, Butler, Gwenaella, Rescourio, Benjamin C, Milgram, Robert S, Foti, Thomas, Kornecook, Joseph, Ligutti, Bryan D, Moyer, Kristin, Taborn, Beth D, Youngblood, Violeta, Yu, Roman, Shimanovich, Alessandro, Boezio, Matthew, Weiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::026ead5bb43373a0b3209260097690d4
https://pubmed.ncbi.nlm.nih.gov/35850422
https://pubmed.ncbi.nlm.nih.gov/35850422
Autor:
Bryan D. Moyer, Brad Herberich, Kaustav Biswas, Kenneth W. Walker, Beth D. Youngblood, Jennifer Aral, Tayo Ikotun, Min-Hwa Jasmine Lin, Linh Tran, Thomas Kornecook, Hongyan Li, Thomas Nixey, Joseph Ligutti, Shanti Amagasu, Li Yin, Xuhai Be, Kristin L. Andrews, Christopher M. Tegley, Charles Glaus, Marcus Soto, Les P. Miranda, James R. Falsey, Jason Long, Yuan Cheng, Robert S. Foti, Hossein Salimi-Moosavi, Kelvin Sham, Christopher P Ilch, Bin Wu, Justin K. Murray, Margaret Karow, Chawita Netirojjanakul, Liz Doherty
Publikováno v:
ACS Chemical Biology. 14:806-818
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel NaV1.7, is being pursued to address the unmet medical need with respect to chronic pain and the rising opioid epidemic. As part of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d1aa4016111a37796e962e98dcd944
https://doi.org/10.1021/acschembio.9b00183
https://doi.org/10.1021/acschembio.9b00183
Autor:
Robert T. Fremeau, Isaac E. Marx, Emily A. Peterson, Charles Kreiman, Thomas Dineen, Hua Gao, Alessandro Boezio, Hakan Gunaydin, Min-Hwa Jasmine Lin, Steven Altmann, Elma Feric Bojic, Kristin Taborn, Robert S. Foti, Russell Graceffa, Daniel S. La, Liyue Huang, Matthew Weiss, Paul E. Rose, Angel Guzman-Perez, Beth D. Youngblood, Hongbing Huang, Violeta Yu, Dong Liu, Thomas Kornecook, Bryan D. Moyer, Howard Bregman, Hanh Nho Nguyen, Joseph Ligutti, Margaret Y. Chu-Moyer, Michael Jarosh, Erin F. DiMauro
Publikováno v:
Journal of Medicinal Chemistry. 60:5969-5989
Several reports have recently emerged regarding the identification of heteroarylsulfonamides as NaV1.7 inhibitors that demonstrate high levels of selectivity over other NaV isoforms. The optimization of a series of internal NaV1.7 leads that address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3616b7030b42538cb45a4828f9c4821e
https://doi.org/10.1021/acs.jmedchem.6b01851
https://doi.org/10.1021/acs.jmedchem.6b01851
Autor:
Robert S. Foti, Brian A. Sparling, Thomas Kornecook, Erin F. DiMauro, Joseph Ligutti, Angel Guzman-Perez, Shuyan Yi, Howie Bregman, Michael Jarosh, Hua Gao, Hongbing Huang, Violeta Yu, Beth D. Youngblood, Bryan D. Moyer, Jessica Able, Benjamin Charles Milgram, Matthew Weiss
Publikováno v:
MedChemComm. 8:744-754
NaV1.7 is a particularly compelling target for the treatment of pain. Herein, we report the discovery and evaluation of a series of piperazine amides that exhibit state-dependent inhibition of NaV1.7. After demonstrating significant pharmacodynamic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0547c7c59fef471565d7454331d0af
https://doi.org/10.1039/c6md00578k
https://doi.org/10.1039/c6md00578k
Autor:
Jeffrey Clarine, Qingyian Liu, Beth D. Youngblood, Chester Chenguang Yuan, Michelle Horner, James Brown, Jian J. Chen, Michael D. Bartberger, Vu Van Ma, Matthew R. Kaller, Carl D. Davis, Maosheng Zhang, Thomas T. Nguyen, Narender R. Gavva, Scott Harried, Sonya G. Lehto, Jennifer R. Allen, Holger Monenschein, Daniel B. Horne, Vijay Keshav Gore, Wenge Zhong, Kaustav Biswas
Publikováno v:
Journal of medicinal chemistry. 61(18)
Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system, including nerve circuitry i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c32a8bd8200356c5984cf6c6b54e8a8
https://pubmed.ncbi.nlm.nih.gov/30148953
https://pubmed.ncbi.nlm.nih.gov/30148953
Autor:
Cheryl L. Stucky, Patrick C. Kerstein, Maosheng Zhang, Kenneth D. Wild, Beth D. Youngblood, Carl Davis, Judy Wang, Weiya Wang, Andy D. Weyer, Sonya G. Lehto, Narender R. Gavva
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology
TRPM8 has been implicated in pain and migraine based on dorsal root- and trigeminal ganglion-enriched expression, upregulation in preclinical models of pain, knockout mouse studies, and human genetics. Here, we evaluated the therapeutic potential in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3200e74bacd3a064fa87df6decbd3609
https://doi.org/10.1007/s00210-015-1090-9
https://doi.org/10.1007/s00210-015-1090-9
Autor:
Matthew M, Weiss, Thomas A, Dineen, Isaac E, Marx, Steven, Altmann, Alessandro, Boezio, Howard, Bregman, Margaret, Chu-Moyer, Erin F, DiMauro, Elma, Feric Bojic, Robert S, Foti, Hua, Gao, Russell, Graceffa, Hakan, Gunaydin, Angel, Guzman-Perez, Hongbing, Huang, Liyue, Huang, Michael, Jarosh, Thomas, Kornecook, Charles R, Kreiman, Joseph, Ligutti, Daniel S, La, Min-Hwa Jasmine, Lin, Dong, Liu, Bryan D, Moyer, Hanh N, Nguyen, Emily A, Peterson, Paul E, Rose, Kristin, Taborn, Beth D, Youngblood, Violeta, Yu, Robert T, Fremeau
Publikováno v:
Journal of medicinal chemistry. 60(14)
Several reports have recently emerged regarding the identification of heteroarylsulfonamides as Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7836a4ad57471118cec766361a3f5db3
https://pubmed.ncbi.nlm.nih.gov/28287723
https://pubmed.ncbi.nlm.nih.gov/28287723
Autor:
Robert T. Fremeau, Robert S. Foti, Hanh Nho Nguyen, Jeff S. McDermott, Jean Wang, Christiane Bode, Bingfan Du, Joseph Ligutti, Thomas Dineen, Hua Gao, Thomas Kornecook, Jonathan Roberts, Brian E. Hall, Charles Kreiman, Liyue Huang, Matthew Weiss, Jessica Able, Min-Hwa Jasmine Lin, Paul E. Rose, Isaac E. Marx, Emily A. Peterson, Violeta Yu, Erin F. DiMauro, Bryan D. Moyer, Daniel S. La, Beth D. Youngblood, Dong Liu, Margaret Y. Chu-Moyer, Hakan Gunaydin, Howard Bregman
Human genetic evidence has identified the voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e82bfc2625ad2b8c686cc56a8b01002
https://europepmc.org/articles/PMC5346988/
https://europepmc.org/articles/PMC5346988/
Autor:
E Galbreath, Sonya G. Lehto, N Rampal, C Yang, Beth D. Youngblood, Stephen G. Waxman, Dong Liu, M Lepherd, Jacinthe Gingras, Bryan D. Moyer, David J. Matson, Maosheng Zhang, Matthew Alsaloum, S Allred, Kristin Taborn, R Ferrando, B Grubinska, Sulayman D. Dib-Hajj, Thomas Kornecook, Lubin Chen
Publikováno v:
Molecular Pain. 15:174480691988184
Recapitulating human disease pathophysiology using genetic animal models is a powerful approach to enable mechanistic understanding of genotype–phenotype relationships for drug development. NaV1.7 ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5779b7f55a15c23d06f4c5941462e7
https://doi.org/10.1177/1744806919881846
https://doi.org/10.1177/1744806919881846
Autor:
Bryan D. Moyer, Kenneth D. Wild, Beth D. Youngblood, Ruoyuan Yin, Stephanie D. Geuns-Meyer, Weiya Wang, Narender R. Gavva, Cheryl L. Stucky, Yohannes Teffera, Maosheng Zhang, Andy D. Weyer, Sonya G. Lehto, Laurie B. Schenkel, Melanie Cooke
Publikováno v:
Molecular Pain
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b35562945641692797c3a369d322e88
http://europepmc.org/articles/PMC5131813
http://europepmc.org/articles/PMC5131813