Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Beth Churchill"'
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Akademický článek
Co-Evolution of Opioid and Adrenergic Ligands and Receptors: Shared, Complementary Modules Explain Evolution of Functional Interactions and Suggest Novel Engineering Possibilities
Autor: Robert Root-Bernstein, Beth Churchill
Publikováno v: Life, Vol 11, Iss 11, p 1217 (2021)
Cross-talk between opioid and adrenergic receptors is well-characterized and involves second messenger systems, the formation of receptor heterodimers, and the presence of extracellular allosteric binding regions for the complementary ligand; however
Externí odkaz: https://doaj.org/article/ebbaed48e183491a800d414444cfde4a
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2
Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse
Autor: Beth Churchill, Miah Turke, Robert Root-Bernstein
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6230, p 6230 (2020)
Volume 21
Issue 17
Opioids and their antagonists alter vitamin C metabolism. Morphine binds to glutathione (l-&gamma
glutamyl-l-cysteinyl-glycine), an intracellular ascorbic acid recycling molecule with a wide range of additional activities. The morphine metabolit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a970c015987fc6c7b9ba7fe01f523c23
https://doi.org/10.3390/ijms21176230
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3
Mutual Enhancement of Opioid and Adrenergic Receptors by Combinations of Opioids and Adrenergic Ligands Is Reflected in Molecular Complementarity of Ligands: Drug Development Possibilities
Autor: Robert Root-Bernstein, Joerg Labahn, Miah Turke, Udaya Kumar Tiruttani Subhramanyam, Beth Churchill
Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 17
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4137 (2019)
Crosstalk between opioid and adrenergic receptors is well characterized and due to interactions between second messenger systems, formation of receptor heterodimers, and extracellular allosteric binding regions. Both classes of receptors bind both se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f25c74bee12b0edbd519ceccfa79dc
https://doi.org/10.3390/ijms20174137
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4
Adrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to 'Biased Opioids'?
Autor: Joerg Labahn, Beth Churchill, Udaya Kumar Tiruttani Subhramanyam, Miah Turke, Robert Root-Bernstein
Publikováno v: International journal of molecular sciences 19(1), 272 (2018). doi:10.3390/ijms19010272
International Journal of Molecular Sciences; Volume 19; Issue 1; Pages: 272
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 1, p 272 (2018)
Extensive evidence demonstrates functional interactions between the adrenergic and opioid systems in a diversity of tissues and organs. While some effects are due to receptor and second messenger cross-talk, recent research has revealed an extracellu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdb9d1112630b1bad2ae0272f42ffcc
https://doi.org/10.3390/ijms19010272
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