Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Beth Burgwyn, Fuchs"'
Autor:
Nagendran Tharmalingam, Shi Xu, Lewis Oscar Felix, Biswajit Roy, Ming Xian, Eleftherios Mylonakis, Beth Burgwyn Fuchs
Publikováno v:
Frontiers in Antibiotics, Vol 2 (2023)
IntroductionThere is a significant need for new antimicrobial compounds that are effective against drug-resistant microbes. Thioredoxin reductase (TrxR) is critical in redox homeostasis and was identified as a potential drug target and confirmed thro
Externí odkaz:
https://doaj.org/article/5f8c6316040741448ba02e55f99dcb81
Autor:
LewisOscar Felix, Cutler Whitely, Nagendran Tharmalingam, Biswajit Mishra, Noel Vera-Gonzalez, Eleftherios Mylonakis, Anita Shukla, Beth Burgwyn Fuchs
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Microbe entry through catheter ports can lead to biofilm accumulation and complications from catheter-related bloodstream infection and ultimately require antimicrobial treatment and catheter replacement. Although strides have been made with microbia
Externí odkaz:
https://doaj.org/article/34629ca83fbb4c729ccb199222a79b14
Autor:
Biswajit Mishra, Rajamohammed Khader, Lewis Oscar Felix, Marissa Frate, Eleftherios Mylonakis, Susan Meschwitz, Beth Burgwyn Fuchs
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Antimicrobial compounds can combat microbes through modulating host immune defense, inhibiting bacteria survival and growth, or through impeding or inhibiting virulence factors. In the present study, a panel of substituted diphenyl amide compounds pr
Externí odkaz:
https://doaj.org/article/07a07223bd2c42c7b7fab8a77e8951a0
Autor:
Patrícia Pimentel de Barros, Rodnei Dennis Rossoni, Maíra Terra Garcia, Valéria de Lima Kaminski, Flávio Vieira Loures, Beth Burgwyn Fuchs, Eleftherios Mylonakis, Juliana Campos Junqueira
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Candida albicans is the main fungal species associated with the development of oral candidiasis. Currently, therapeutic options for these infections are limited by the adverse effects of antifungal drugs and by the emergence of drug resistant strains
Externí odkaz:
https://doaj.org/article/d18bf0cdaf3b429cb16706381a14bc64
Autor:
Beth Burgwyn Fuchs, Sudha Chaturvedi, Rodnei Dennis Rossoni, Patricia P de Barros, Fernando Torres-Velez, Eleftherios Mylonakis, Vishnu Chaturvedi
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 1539-1547 (2018)
Laboratory investigations of the pathogenesis of Pseudogymnoascus destructans, the fungal causal agent of bat White Nose Syndrome (WNS), presents unique challenges due to its growth requirements (4°-15°C) and a lack of infectivity in the current di
Externí odkaz:
https://doaj.org/article/c3eb26b0cc0e4d2c8a3d7c5e669dd156
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has emerged from multiple screening efforts as a potential target for auranofin
Externí odkaz:
https://doaj.org/article/ebf37e043cb14c7e83cb29ca4dc182fb
Autor:
Rodnei Dennis Rossoni, Patrícia Pimentel de Barros, Iatã do Carmo Mendonça, Rebeca Previate Medina, Dulce Helena Siqueira Silva, Beth Burgwyn Fuchs, Juliana Campos Junqueira, Eleftherios Mylonakis
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Candida auris has emerged as a medically important pathogen with considerable resistance to antifungal agents. The ability to produce biofilms is an important pathogenicity feature of this species that aids escape of host immune responses and antimic
Externí odkaz:
https://doaj.org/article/431f007248f348c8a31f91e1c21279bd
Autor:
Jéssica Diane dos Santos, Luciana Ruano de Oliveira Fugisaki, Rebeca Previate Medina, Liliana Scorzoni, Mariana de Sá Alves, Patrícia Pimentel de Barros, Felipe Camargo Ribeiro, Beth Burgwyn Fuchs, Eleftherios Mylonakis, Dulce Helena Siqueira Silva, Juliana Campos Junqueira
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
In the oral cavity, Candida species form mixed biofilms with Streptococcus mutans, a pathogenic bacterium that can secrete quorum sensing molecules with antifungal activity. In this study, we extracted and fractioned culture filtrate of S. mutans, se
Externí odkaz:
https://doaj.org/article/49297368648d4e3ab08db5f124024926
Autor:
Lianfang Wang, Ruilan Chen, Qiuting Weng, Shaoming Lin, Huijun Wang, Li Li, Beth Burgwyn Fuchs, Xiaojiang Tan, Eleftherios Mylonakis
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Candida albicans is the most common fungal pathogen and relies on the Hog1-MAPK pathway to resist osmotic stress posed by the environment or during host invasions. Here, we investigated the role of SPT20 in response to osmotic stress. Testing a C. al
Externí odkaz:
https://doaj.org/article/7d390281000949b5b3ec443cf97ba4a3
Autor:
Ana María Garzón Porras, Bruna Silva Terra, Taniris Cafiero Braga, Thais Furtado Ferreira Magalhães, Cleide Viviane Buzanello Martins, Danielle Letícia da Silva, Ludmila Matos Baltazar, Ludmila Ferreira Gouveia, Gustavo José Cota de Freitas, Daniel Assis Santos, Maria Aparecida Resende-Stoianoff, Beth Burgwyn Fuchs, Eleftherios Mylonakis, Rossimiriam Pereira de Freitas, Ângelo de Fátima
Publikováno v:
Journal of Advanced Research, Vol 14, Iss , Pp 81-91 (2018)
The incidence of fungal infections is considered a serious public health problem worldwide. The limited number of antimycotic drugs available to treat human and animal mycosis, the undesirable side effects and toxicities of the currently available dr
Externí odkaz:
https://doaj.org/article/dd1efab29fca452e922562490979816e