Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Beth Bready"'
Publikováno v:
Anti-Cancer Drugs. 7:728-733
We conducted two consecutive phase I clinical trials to identify the qualitative and quantitative toxic effects of uracil-tegafur (UFT) [Taiho Pharmaceutical Co. Ltd, Tokyo, Japan; (BMS-200604) Bristol-Myers Squibb, Princeton, NJ] administered either
Autor:
Steven Sugarman, Bernard Levin, Beth Bready, Avi B. Markowitz, Yehuda Z. Patt, Richard Pazdur, Jaffer A. Ajani, Yvonne Lassere, Virginia Rhodes, Dennie V. Jones, James L. Abbruzzese
Publikováno v:
Journal of Clinical Oncology. 12:2296-2300
PURPOSE To determine the activity and evaluate the toxicity of uracil and tegafur in a 4:1 molar concentration (UFT; Taiho Pharmaceutical Ltd, Tokyo, Japan) plus oral calcium leucovorin in the treatment of patients with advanced colorectal carcinoma.
Publikováno v:
Journal of Surgical Oncology. 53:127-130
Hepatoblastomas (HBs) and hepatocellular carcinomas (HCCs) constitute the majority of hepatic tumors in children. Although most children who have HB or HQC present with unresectable disease, chemotherapy may reduce the size of the primary tumor and m
Autor:
Lawrence A. Trissel, Beth Bready
Publikováno v:
American Journal of Health-System Pharmacy. 49:1716-1719
The compatibility of taxol in 5% dextrose injection with each of 17 other drugs during simulated Y-site injection was studied through visual and turbidimetric assessment. A 4-mL sample of taxol 1.2 mg/mL in 5% dextrose injection was combined with a 4
Publikováno v:
American Journal of Health-System Pharmacy. 49:402-406
Autor:
James L. Abbruzzese, Dennie V. Jones, Scott M. Lippman, Steve Sugarman, Dennis F. Moore, Beth Bready, Richard Pazdur
Publikováno v:
American Journal of Clinical Oncology. 18:525-527
The combination of interferons (IFNs) and retinoids in antineoplastic therapy is based upon preclinical, in vitro, and in vivo observations. Retinoid-IFN combinations have shown significant antitumor activity against advanced cutaneous and cervical s
Autor:
Rodger J. Winn, Anthony J. Scalzo, Beth Bready, David R. Close, Richard Pazdur, James E. Brandof, Sharon Kolbye
Publikováno v:
Investigational New Drugs. 12:263-265
Piroxantrone, a synthetic intercalating agent, was studied in patients with advanced, measurable gastric adenocarcinoma who had not received prior chemotherapy. The starting piroxantrone dose was 150 mg/m2 given intravenously over 1 hour on day 1 and
Autor:
William McGarry, Beth Bready, Richard Pazdur, J. Wendall Goodwin, Robert J. Belt, Shaker R. Dakhil, Melanie E. Royce, Rodger J. Winn, Paulo M. Hoff, Richard Gray
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 17(10)
PURPOSE: Several agents have been evaluated for their effect as biochemical modulators of fluorouracil (5-FU) in the treatment of metastatic colorectal carcinoma. In this study, we used folinic acid (FA), N-phosphonacetyl-L-aspartic acid (PALA), and
Autor:
Rodger J. Winn, James L. Abbruzzese, Dennis F. Moore, Richard Pazdur, Robert J. Belt, Beth Bready, C. Mangold, James L. Wade, Jaffer A. Ajani, D. W. Dubovsky
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 5(3)
Summary Background The methotrexate analogue 10-ethyl-10-deazaaminopterin (10-EdAM, or edatrexate) has shown antitumor activity in preclinical testing and clinical studies of patients with breast, lung and head and neck carcinomas. A phase II study w
Autor:
Robert A. Newman, M. Bayssas, Richard Pazdur, Beth Bready, Franzanne Vreeland, Angela Fuentes, John A. Benvenuto, Martin N. Raber, Beverly M. Newman, Dennis Moore, Ishmael Jaiyesimi
Publikováno v:
Journal of the National Cancer Institute. 84(23)
Background Taxotere, a semisynthetic compound structurally related to taxol, has a broad spectrum of activity in murine transplantable tumors; in the B16 melanoma model, it caused a total log cell kill 2.5 times greater than that caused by taxol at e