Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Beth Basham"'
Autor:
Christopher J. Haines, Yi Chen, Wendy M. Blumenschein, Renu Jain, Charlie Chang, Barbara Joyce-Shaikh, Katherine Porth, Katia Boniface, Jeanine Mattson, Beth Basham, Stephen M. Anderton, Terrill K. McClanahan, Svetlana Sadekova, Daniel J. Cua, Mandy J. McGeachy
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1378-1388 (2013)
Interleukin-23 (IL-23) is essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, but its role in memory Th17 cell responses is unclear. Using the experimental autoimmune encephalomyelitis (EAE) model, we report that memory
Externí odkaz:
https://doaj.org/article/5ac0564804e04566b58c8944b9a68bc7
Autor:
Beth Basham, Mandy J. McGeachy, Daniel J. Cua, Terrill K. McClanahan, Katia Boniface, Christopher Haines, Charlie Chang, Svetlana Sadekova, Jeanine D. Mattson, Yi Chen, Renu Jain, Wendy M. Blumenschein, Katherine Porth, Barbara Joyce-Shaikh, Stephen M. Anderton
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1378-1388 (2013)
Haines, C J, Chen, Y, Blumenschein, W M, Jain, R, Chang, C, Joyce-Shaikh, B, Porth, K, Boniface, K, Mattson, J, Basham, B, Anderton, S M, McClanahan, T K, Sadekova, S, Cua, D J & McGeachy, M J 2013, ' Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23 ', Cell Reports, vol. 3, no. 5, pp. 1378-1388 . https://doi.org/10.1016/j.celrep.2013.03.035
Haines, C J, Chen, Y, Blumenschein, W M, Jain, R, Chang, C, Joyce-Shaikh, B, Porth, K, Boniface, K, Mattson, J, Basham, B, Anderton, S M, McClanahan, T K, Sadekova, S, Cua, D J & McGeachy, M J 2013, ' Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23 ', Cell Reports, vol. 3, no. 5, pp. 1378-1388 . https://doi.org/10.1016/j.celrep.2013.03.035
SummaryInterleukin-23 (IL-23) is essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, but its role in memory Th17 cell responses is unclear. Using the experimental autoimmune encephalomyelitis (EAE) model, we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d516e0abb4bbe1986622024f6565dd
http://www.sciencedirect.com/science/article/pii/S2211124713001599
http://www.sciencedirect.com/science/article/pii/S2211124713001599
Autor:
Gulesi Ayanoglu, Erin Murphy, Scott P. Turner, Amy M Beebe, Ivan H. Chan, John B. Mumm, Venkataraman Sriram, Xueqing Zhang, Catherine Sheppard, Jeff Grein, Beth Basham, Martin Oft, Satya Medicherla, Jan Emmerich, Melanie A. Kleinschek, Lingling Wu, Michael Judo, Steven J. Blaisdell, Terrill K. McClanahan, Susan Cannon-Carlson, John L. Langowski, Danling Gu, Kyu Hong, Wolfgang Seghezzi, Smita Mauze, Brittany C. Paporello, Bela Desai, Saraswathi Naravula, Jie Dai, Drake LaFace, Collette M. Cutler
Publikováno v:
Cancer Cell. 20(6):781-796
Summary Tumor immune surveillance and cancer immunotherapies are thought to depend on the intratumoral infiltration of activated CD8 + T cells. Intratumoral CD8 + T cells are rare and lack activity. IL-10 is thought to contribute to the underlying im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be7a3a8453fea6fe1ae6913680436ca
Autor:
Mandy J. McGeachy, Bela Desai, Robert H. Pierce, Katia Boniface, Svetlana Sadekova, Terrill K. McClanahan, Katherine Brovont-Porth, Beth Basham, Rene de Waal Malefyt, Wendy M. Blumenschein
Publikováno v:
The Journal of Immunology. 185:679-687
Th17 cells have been named after their signature cytokine IL-17 and accumulating evidence indicates their involvement in the induction and progression of inflammatory diseases. In addition to IL-17 single-producing T cells, IL-17/IFN-γ double-positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8e2c0e6613fa4ad8f873ce2745b841
https://doi.org/10.4049/jimmunol.1000366
https://doi.org/10.4049/jimmunol.1000366
Autor:
Jeffrey Grein, Anne Rascle, Annalisa D’Andrea, Manjiri Sathe, Beth Basham, Emma Lees, Terrill McClanahan
Publikováno v:
Nucleic Acids Research
STAT5A and STAT5B proteins belong to the family of signal transducers and activators of transcription. They are encoded by two separate genes with 91% identity in their amino acid sequences. Despite their high degree of conservation, STAT5A and STAT5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd91e99eac8aa2afb0fba61e2ae6dd3
https://doi.org/10.1093/nar/gkn271
https://doi.org/10.1093/nar/gkn271
Autor:
Ware G. Kuschner, Lynn M. Hildemann, Wayne R. Ott, James Canfield, Karin M. Abitorabi, Sebnem Guvenc-Tuncturk, Gordon K. Mak, Rene de Waal Malefyt, Terrill K. McClanahan, Jeanine D. Mattson, Robert B. Fick, Brian M. Haus, Beth Basham, Madhuri Agrawal, Bela Desai, Wei Ding
Publikováno v:
Experimental Lung Research. 34:631-662
Chronic obstructive pulmonary diseases (COPD) may increase air pollution-related mortality. The relationship of immune mechanisms to mortality caused by fine particulates in healthy and COPD populations is incompletely understood. The objective of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b490e6edb962e18f723b8577fd92ba
https://doi.org/10.1080/01902140802322256
https://doi.org/10.1080/01902140802322256
Autor:
Nicholas J. Wilson, Edward P. Bowman, Jeanine D. Mattson, Taiying Chen, Kathleen M. Smith, Brent S. McKenzie, Robert A. Kastelein, Terrill K. McClanahan, Beth Basham, Rene de Waal Malefyt, Katia Boniface, Wendy M. Blumenschein, Franck Morel, Jean-Claude Lecron, Daniel J. Cua, Jason R. Chan
Publikováno v:
Nature Immunology. 8:950-957
T(H)-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the T(H)-17 lineage is dependent on transforming growth factor-beta and interleukin 6 (IL-6). Here we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e8065f3e2d695429684e32bbabb6a4
https://doi.org/10.1038/ni1497
https://doi.org/10.1038/ni1497
Autor:
Jeanine D. Mattson, Martin Oft, Terrill K. McClanahan, Taiying Chen, John L. Langowski, Kathy Smith, Beth Basham, Xueqing Zhang, Robert A. Kastelein, Lingling Wu
Publikováno v:
Nature. 442:461-465
Chronic inflammation has long been associated with increased incidence of malignancy and similarities in the regulatory mechanisms have been suggested for more than a century. Infiltration of innate immune cells, elevated activities of matrix metallo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b00233dcea3f9868444e3166d34cc8
https://doi.org/10.1038/nature04808
https://doi.org/10.1038/nature04808
Autor:
Beth Basham, Robert A. Kastelein, Jeanine D. Mattson, Wendy M. Blumenschein, Claire L. Langrish, Terrill K. McClanahan, Daniel J. Cua, Yi Yi Chen, Jonathan D. Sedgwick
Publikováno v:
The Journal of Experimental Medicine
Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a264787318f32948c6ea0638476d25b
https://doi.org/10.1084/jem.20041257
https://doi.org/10.1084/jem.20041257
Autor:
Charlie Chang, Edward P. Bowman, E Penaflor, Rob Kastelein, Drake LaFace, Franklin Vives, Marlowe S. Tessmer, Scott P. Turner, Manjiri Sathe, Christina Moon, Beth Basham, Terri McClanahan, Daniel M. Gorman, Daniel J. Cua, Ruban Mangadu, Ivan H. Chan, John B. Mumm, Robert H. Pierce, Renu Jain, Jennifer H. Yearley, Joseph H. Phillips, Gulesi Ayanoglu
Publikováno v:
Mucosal immunology. 7(4)
Chronic inflammation has been associated with increased risk for developing gastrointestinal cancer. Interleukin-23 (IL-23) receptor signaling has been correlated with inflammatory bowel disease pathogenesis, as well as promotion of tumor growth. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d785d05740b99e2031a30c5fc277d35
https://pubmed.ncbi.nlm.nih.gov/24280935
https://pubmed.ncbi.nlm.nih.gov/24280935