Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Beth Ann Thomas"'
Autor:
Mark Cunningham, Vedrana Stojanovic-Susulic, Karyn T. O'Neil, Daniel J. Drucker, Kristen Picha, Ashok Mathur, Tracy Spinka-Doms, Beth Ann Thomas, Tatiana Ort, Michael Scully, Avery Soderman
Publikováno v:
Diabetes
OBJECTIVE—We have developed a novel platform for display and delivery of bioactive peptides that links the biological properties of the peptide to the pharmacokinetic properties of an antibody. Peptides engineered in the MIMETIBODY platform have im
Autor:
Mark L. Brader, Michael L. Roy, Allen H. Pekar, Brandon Doyle, Beth Ann Thomas, Mark J. Pollo
Publikováno v:
Journal of Pharmaceutical Sciences. 94:2749-2763
LY307161 is a 31 amino acid analog of glucagonlike peptide-1(7-37)OH susceptible to physical instability associated with pharmaceutical processing. Orthogonal biophysical studies were conducted to explore the origins of this physical instability and
Autor:
Donna Bozyczko-Coyne, Beth Ann Thomas, Michael S. Saporito, Zhi-Liang Wu, Ghanashyam D. Ghadge, Stephen P. Trusko, Maroney Anna, Joanne R. Mathiasen, Beth Ann McKenna, Beverly P. Holskin, Raymond P. Roos, Jeffrey C. Thomas, Thomas C. Connors
Publikováno v:
Brain Research. 1003:86-97
The neuropathology of Parkinson's Disease has been modeled in experimental animals following MPTP treatment and in dopaminergic cells in culture treated with the MPTP neurotoxic metabolite, MPP(+). MPTP through MPP(+) activates the stress-activated c
Autor:
Joanne R. Mathiasen, Teresa M. O'Kane, Beth Ann McKenna, Robert L. Hudkins, Donna Bozyczko-Coyne, Masami Kaneko, George W. Gessner, Beth Ann Thomas, Mark A. Ator, Thelma S. Angeles, Chikara Murakata, Michael S. Saporito
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:147-150
The MLK1-3 activity for a series of analogues of the indolocarbazole K-252a is reported. Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-
Publikováno v:
Proteins: Structure, Function, and Genetics. 34:184-196
Juvenile Hormone Esterase (JHE) plays an essential role in the development of insects since it is partially responsible for clearing juvenile hormone (JH), one of the hormones that is responsible for insect metamorphosis. JHE is a 60 kDa enzyme that
Autor:
Young Moo Lee, Bruce D. Hammock, Masataka Kuroda, Revital Herrmann, Rafael Herrmann, Elisabeth Lehmberg, Yoshiaki Nakagawa, Haim Moskowitz, A. Daniel Jones, Ryo Shimizu, Martin Sadilek, Beth Ann Thomas
Publikováno v:
Archives of Insect Biochemistry and Physiology. 38:53-65
As recombinant viruses expressing scorpion toxins are moving closer toward the market, it is important to obtain large amounts of pure toxin for biochemical characterization and the evaluation of biological activity in nontarget organisms. In the pas
Autor:
Subba Reddy Palli, Anthony J. Lentz, Lynn M. Riddiford, Bruce D. Hammock, Hubert Wojtasek, Jean-Philippe Charles, Anthony G. Parker, Glenn D. Prestwich, Bryony C. Bonning, Beth Ann Thomas, György Dormán
Publikováno v:
Archives of Insect Biochemistry and Physiology. 31:371-393
Publikováno v:
Biochemistry. 34:3758-3770
A posttranslationally methylated asparagine residue, N5-methylasparagine, is found at the beta-72 site in many phycobiliproteins. Two mutations (Asp and Gln) in the beta-72 position of Agmenellum quadruplicatum C-phycocyanin were investigated to clar
Autor:
Alan V. Klotz, Beth Ann Thomas
Publikováno v:
The Journal of Organic Chemistry. 58:6985-6989
The chemistry of peptides containing N 5 -methylasparagine (NMA) was investigated by incubating the synthetic peptides Ile-Ala-Pro-Gly-Gly-Asn-Gly-Tyr and Ile-Ala-Pro-Gly-Gly-NMA-Gly-Tyr at 60 o C in 0.1 M NaPO 4 , PH 7.4, to assay for peptide deamid
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1143:104-108
A post-translationally methylated asparagine residue, γ-N- methylasparagine (NMA), is found at the β-72 site in many phycobiliproteins. We have examined the effects of asparagine methylation on photosynthetic rates in the wild-type cyanobacterium S