Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Beth A. Winkelstein"'
Publikováno v:
Frontiers in Rehabilitation Sciences, Vol 5 (2024)
BackgroundMatching disease and treatment mechanisms is a goal of the Precision Medicine Initiative. Pro- and anti-inflammatory cytokines (e.g., Tumor Necrosis Factor-alpha, Transforming Growth Factor-beta, and Interleukin-2, 10, and 12) have gained a
Externí odkaz:
https://doaj.org/article/4a7c0cea74c8448a8a808e814b6b6f73
Autor:
Maryam Nikpasand, Rebecca E. Abbott, Craig C. Kage, Sagar Singh, Beth A. Winkelstein, Victor H. Barocas, Arin M. Ellingson
Publikováno v:
JOR Spine, Vol 6, Iss 3, Pp n/a-n/a (2023)
Abstract Background To understand the facet capsular ligament's (FCL) role in cervical spine mechanics, the interactions between the FCL and other spinal components must be examined. One approach is to develop a subject‐specific finite element (FE)
Externí odkaz:
https://doaj.org/article/84d1ac06d1ed48d98f0c761ce78d78c2
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Chronic joint pain is a major healthcare challenge with a staggering socioeconomic burden. Pain from synovial joints is mediated by the innervated collagenous capsular ligament that surrounds the joint and encodes nociceptive signals. The interstitia
Externí odkaz:
https://doaj.org/article/bfdb78821310484ba39d035dc45bafd4
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Degeneration is a hallmark of painful joint disease and is mediated by many proteases that degrade joint tissues, including collagenases. We hypothesized that purified bacterial collagenase would initiate nociceptive cascades in the joint by
Externí odkaz:
https://doaj.org/article/344c81ec75a94e67b683c5bfb1e94eab
Autor:
Meagan E. Ita, Beth A. Winkelstein
Publikováno v:
Frontiers in Mechanical Engineering, Vol 8 (2022)
Chronic joint pain is a major health problem that can result from abnormal loading of the innervated ligamentous capsule that surrounds synovial joints. The matrix metalloproteinases-1 (MMP-1) and MMP-9 are hypothesized pain mediators from stretch-in
Externí odkaz:
https://doaj.org/article/99e04d91400a4fa38e50fe8316cabcbf
Publikováno v:
PAIN Reports, Vol 6, Iss 1, p e911 (2021)
Abstract. Introduction:. Temporomandibular joint (TMJ) pain is among the most prevalent musculoskeletal conditions and can result from atypical joint loading. Although TMJ pain is typically self-resolving, 15% of patients develop chronic TMJ pain tha
Externí odkaz:
https://doaj.org/article/85717ac83868437e9752c71ca27594ab
Autor:
Sonia Kartha, Christine L. Weisshaar, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou, Beth A. Winkelstein
Publikováno v:
Antioxidants, Vol 9, Iss 12, p 1209 (2020)
Painful cervical radiculopathy is characterized by chronic neuroinflammation that lowers endogenous antioxidant responses leading to the development of oxidative stress and pain after neural trauma. Therefore, antioxidants such as secoisolariciresino
Externí odkaz:
https://doaj.org/article/ac2a92996c7d410b80c6d47bda98a4c1
Autor:
Thomas W. Evashwick‐Rogler, Alon Lai, Hironobu Watanabe, Jonathan M. Salandra, Beth A. Winkelstein, Samuel K. Cho, Andrew C. Hecht, James C. Iatridis
Publikováno v:
JOR Spine, Vol 1, Iss 2, Pp n/a-n/a (2018)
Background Painful intervertebral disc (IVD) degeneration has tremendous societal costs and few effective therapies. Intradiscal tumor necrosis factor‐alpha (TNFα) is commonly associated with low back pain, but the direct relationship remains uncl
Externí odkaz:
https://doaj.org/article/45b870f1dfcc4e7fb71a3fc72dac86c5
Publikováno v:
Frontiers in Neurology, Vol 7 (2016)
Neuropathic pain is an example of chronic pain that develops after nerve injury and is less frequent in infants and children than in adults. Likewise, in animal models of neuropathic pain, allodynia and hyperalgesia are non-existent or attenuated in
Externí odkaz:
https://doaj.org/article/1303fa5e370f4be9938fa52fbd1ba68c
Autor:
Daniel L.J. Thorek, Christine L. Weisshaar, Julie C. Czupryna, Beth A. Winkelstein, Andrew Tsourkas
Publikováno v:
Molecular Imaging, Vol 10 (2011)
In many clinical cases of radicular pain, no noticeable neuropathology is detected by conventional medical imaging strategies. Superparamagnetic iron oxide (SPIO) nanoparticles were evaluated as magnetic resonance contrast agents to specifically dete
Externí odkaz:
https://doaj.org/article/f276910f3678411f8216f0eabe3e7378