Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Beth A. Rasmussen"'
Autor:
Pornpen Labthavikul, William Hu, Shaughnessy M. Naughton, Youjun Yang, David Keeney, Beth A. Rasmussen, Craig E. Caufield, Koi Michele Morris, Peter Petersen, Guy Singh, Schuyler Adam Antane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:176-180
Pulvinones were synthesized (>180) in arrays and evaluated as inhibitors of early stage cell wall biosynthesis enzymes MurA-MurD. Several pulvinones inhibited Mur enzymes with IC(50)'s in the 1-10 microg/mL range and demonstrated antibacterial activi
Autor:
Guy Singh, Girija Krishnamurthy, Jamie M. Davis, Kristina M.K. Kutterer, William Hu, Youjun Yang, Alan H. Katz, Anatoly Severin, Beth A. Rasmussen, Amedeo Arturo Failli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2527-2531
Over 195 4-alkyl and 4,4-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives were synthesized, utilizing microwave accelerated synthesis, for evaluation as new inhibitors of bacterial cell wall biosynthesis. Many of them demonstrated go
Autor:
Nancy H. Eudy, Yang-I Lin, Pornpen Labthavikul, Zhong Li, Peter Petersen, Guy Singh, Gerardo D. Francisco, Youjun Yang, Tarek S. Mansour, J.Donald Albright, Beth A. Rasmussen, Alan H. Katz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:235-238
Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VR
Autor:
Peter Petersen, Tarek S. Mansour, Douglas M. Ho, Emily B. Norton, Guy Singh, Beth A. Rasmussen, Ayako Yamashita, Youjin Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3345-3350
A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme
Autor:
Pornpen Labthavikul, Peter Petersen, Tarek S. Mansour, Guy Singh, Beth A. Rasmussen, Jerauld S. Skotnicki, Gerardo D. Francisco, William Hu, Youjun Yang, Yang-I Lin, Zhong Li, Anatoly Severin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2591-2594
Twenty-five 2-phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives were synthesized for evaluation as new inhibitors of bacterial cell wall biosynthesis. Many of them demonstrated good inhibitory activity against Staphylococcus aureus MurB, Mu
Autor:
Keiko Tabei, Nelson Huang, Yang-I Lin, David M. Shlaes, Beth A. Rasmussen, Katarzyna Janota, Marshall M. Siegel, Youjun Yang
Publikováno v:
Journal of Biological Chemistry. 275:26674-26682
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:2904-2909
The biochemical properties of tetrahydrofuranyl (THF) carbapenems, carbapenems with THF substituents, were evaluated with respect to enzyme stability, binding to penicillin-binding proteins (PBPs), and penetration into gram-negative organisms. THF ca
Publikováno v:
ChemInform. 30
Autor:
Kristine Svenson, Youjun Yang, Dominick Anthony Quagliato, Shaughnessy M. Naughton, Guy Singh, Beth A. Rasmussen, Claudia Smeltzer, Tarek S. Mansour, Joel Bard, Girija Krishnamurthy, Schuyler Adam Antane, Peter Petersen, Koi Michele Morris, Rajiv Chopra, Anatoly Severin, Craig E. Caufield
Publikováno v:
ChemMedChem. 2(10)
Publikováno v:
BMC Genomics, Vol 4, Iss 1, p 36 (2003)
BMC Genomics
BMC Genomics
Background Cloning of genes in expression libraries, such as the yeast two-hybrid system (Y2H), is based on the assumption that the loss of target genes is minimal, or at worst, managable. However, the expression of genes or gene fragments that are c