Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Beth A Weaver"'
Autor:
Amber S Zhou, John B Tucker, Christina M Scribano, Andrew R Lynch, Caleb L Carlsen, Sophia T Pop-Vicas, Srishrika M Pattaswamy, Mark E Burkard, Beth A Weaver
Publikováno v:
PLoS Biology, Vol 21, Iss 10, p e3002339 (2023)
Microtubule-targeted agents are commonly used for cancer treatment, though many patients do not benefit. Microtubule-targeted drugs were assumed to elicit anticancer activity via mitotic arrest because they cause cell death following mitotic arrest i
Externí odkaz:
https://doaj.org/article/45f914589aa54be58c9b45687e9358a8
Publikováno v:
eLife, Vol 11 (2022)
Chromosomal instability (CIN)—persistent chromosome gain or loss through abnormal mitotic segregation—is a hallmark of cancer that drives aneuploidy. Intrinsic chromosome mis-segregation rate, a measure of CIN, can inform prognosis and is a promi
Externí odkaz:
https://doaj.org/article/7f548a7a7f9c4dcaa81c622dfb9ba2ff
Autor:
Ashok Singh, Ryan A. Denu, Serena K. Wolfe, Jamie M. Sperger, Jennifer Schehr, Tessa Witkowsky, Karla Esbona, Richard J. Chappell, Beth A. Weaver, Mark E. Burkard, Joshua M. Lang
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1898-1909 (2020)
Centrosome amplification (CA) is a common phenomenon in cancer, promotes genomic stability and cancer evolution, and has been reported to promote metastasis. CA promotes a stochastic gain/loss of chromosomes during cell division, known as chromosomal
Externí odkaz:
https://doaj.org/article/ab1375b648b54bdda797d99443812184
Autor:
Jun Wan, Samuel Block, Christina M. Scribano, Rebecca Thiry, Karla Esbona, Anjon Audhya, Beth A. Weaver
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Mad1 is well characterised for its function in mitosis. Here, the authors describe an interphase role for Mad1 in tumour promotion in which it destabilises p53 by localizing to PML nuclear bodies and displacing MDM2 from the PML-MDM2 complex.
Externí odkaz:
https://doaj.org/article/2325e2e3c5334028a09c465010f83a6c
Autor:
John B. Tucker, Sarah C. Bonema, Rebeca García-Varela, Ryan A. Denu, Yang Hu, Stephanie M. McGregor, Mark E. Burkard, Beth A. Weaver
Publikováno v:
Cancer Research Communications. 3:54-65
Chromosomal instability (CIN), the persistent reshuffling of chromosomes during mitosis, is a hallmark of human cancers that contributes to tumor heterogeneity and has been implicated in driving metastasis and altering responses to therapy. Though mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0792404a5ec4411c77187e0e624a431
https://doi.org/10.1158/2767-9764.crc-22-0302
https://doi.org/10.1158/2767-9764.crc-22-0302
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Figure S5. Chromosomes that are misaligned at anaphase onset are rapidly incorporated into the main DNA masses during anaphase A. A-B. Timelapse analysis of T47D (A) and Cal51 (B) breast cancer cells with endogenously labeled histone H2B and a-tubuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6daca971fc61414ef241fbc2067d763c
https://doi.org/10.1158/2767-9764.22546121
https://doi.org/10.1158/2767-9764.22546121
Table TS2 from Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Table S2. Patient characteristics of matched primary and metastatic cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e34ab8e26fb838805f0d447a641c43
https://doi.org/10.1158/2767-9764.22546100.v1
https://doi.org/10.1158/2767-9764.22546100.v1
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Misaligned chromosome that persists through anaphase onset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0bf2dffab7cbac76717756bcd40d32
https://doi.org/10.1158/2767-9764.22546115
https://doi.org/10.1158/2767-9764.22546115
Autor:
Beth A. Weaver, Mark E. Burkard, Stephanie M. McGregor, Yang Hu, Ryan A. Denu, Rebeca García-Varela, Sarah C. Bonema, John B. Tucker
Chromosomal instability (CIN), the persistent reshuffling of chromosomes during mitosis, is a hallmark of human cancers that contributes to tumor heterogeneity and has been implicated in driving metastasis and altering responses to therapy. Though mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6a6a0d61550085843e1f30d36336e6
https://doi.org/10.1158/2767-9764.c.6551099.v1
https://doi.org/10.1158/2767-9764.c.6551099.v1
Autor:
Mark E. Burkard, Beth A. Weaver, Sandeep Saha, Kari B. Wisinski, Josephine M. Harter, Jennifer J. Laffin, Craig Kanugh, Hyunjung Kim, Ryan A. Denu, Amber Lasek, Lauren M. Zasadil, Robert F. Lera, Brittany Zachek, Alka Choudhary
This file contains Supplementary Table 1 and provides hazard ratios for recurrence free survival and overall survival for polyploidy and clinical variables using a Cox proportional hazard model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12e9b0c0f29f0af487036bc12d17472
https://doi.org/10.1158/1535-7163.22503648
https://doi.org/10.1158/1535-7163.22503648