Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Beth McKnight"'
Autor:
Bryce Alden Harrison, Lakshman Samala, Nita Patel, Zheng Y. Almstead, N. Andrew Whitlock, Ross Mabon, Dennis S. Rice, Nicole Cathleen Goodwin, Beth McKnight, Yulian Zhang, Jason P. Healy, Shuli Wang, Suma Gopinathan, Gardyan Michael Walter, David B. Rawlins, Alan Wilson, Terry R. Stouch, Ying Liu, Brian D. Hamman, Brett A. Marinelli, Hugh Alfred Burgoon
Publikováno v:
ACS Medicinal Chemistry Letters. 6:84-88
The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is disclosed. Previously reported LIM kinase inhibitors suffered from poor aqueous stability due to solvolysis of the cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd87df001b841d60f0512718b8b7ce9
https://doi.org/10.1021/ml500367g
https://doi.org/10.1021/ml500367g
Publikováno v:
Investigative ophthalmologyvisual science. 51(12)
Purpose Glucocorticoids are potent modulators of the immune system and are useful in treating systemic and ocular diseases, but they can increase intraocular pressure (IOP) in susceptible persons. Steroid-induced ocular hypertension resembles several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf312e12bc0f3e91ed897ae1a3bb8428
https://pubmed.ncbi.nlm.nih.gov/20671272
https://pubmed.ncbi.nlm.nih.gov/20671272
Autor:
Billie Key, Michael Victor Voronkov, Michael J. Crist, N. Andrew Whitlock, Beth McKnight, Suma Gopinathan, Gardyan Michael Walter, Kun Jian Gu, Bryce Alden Harrison, Zheng Y. Almstead, Craig E. Crosson, Ross Mabon, Dennis S. Rice, Phil W. Yates, Alan G. E. Wilson, Jason Allen, Nita Patel, Ying Liu, Brian D. Hamman, David B. Rawlins, Qingyun Liu, Yulian Zhang, Lawrence F. Courtney, Julia Zhou, S. David Kimball
Publikováno v:
Journal of medicinal chemistry. 52(21)
The discovery of a pyrrolopyrimidine class of LIM-kinase 2 (LIMK2) inhibitors is reported. These LIMK2 inhibitors show good potency in enzymatic and cellular assays and good selectivity against ROCK. After topical dosing to the eye in a steroid induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e4f9457a81261ca191393308284554
https://pubmed.ncbi.nlm.nih.gov/19831390
https://pubmed.ncbi.nlm.nih.gov/19831390
Publikováno v:
AIAA SPACE 2007 Conference & Exposition.
PISCES, the Pacific International Space Center for Exploration Systems, has been established on the Big Island of Hawai'i as an integrated research facility and simulated lunar settlement, developing new technologies needed for a sustained human pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52519024bba7977de2fbf4b33fafd4cc
https://doi.org/10.2514/6.2007-6293
https://doi.org/10.2514/6.2007-6293
Autor:
Bryce A. Harrison, N. Andrew Whitlock, Michael V. Voronkov, Zheng Y. Almstead, Kun-jian Gu, Ross Mabon, Michael Gardyan, Brian D. Hamman, Jason Allen, Suma Gopinathan, Beth McKnight, Mike Crist, Yulian Zhang, Ying Liu, Lawrence F. Courtney, Billie Key, Julia Zhou, Nita Patel, Phil W. Yates, Qingyun Liu
Publikováno v:
Journal of Medicinal Chemistry; Nov2009, Vol. 52 Issue 21, p6515-6518, 4p