Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Beth J. Hoffman"'
Autor:
Ryan White, James Brown, Jean-Christophe Harmange, Xiaoyang Xia, Josie Han Lee, Yuan Cheng, Robert T. Fremeau, Beth J. Hoffman, Susan A. Tomlinson, Matthew W. Martin, Liyue Huang, Erin F. DiMauro, Stephen Hitchcock, Hung Q. Nguyen, John L. Buchanan, Vinod F. Patel, Ming Huang, William H. Buckner, Brian K. Albrecht, Fen-Fen Lin, Renee Emkey
Publikováno v:
Journal of Medicinal Chemistry. 51:5019-5034
The CB2 receptor is an attractive therapeutic target for analgesic and anti-inflammatory agents. Herein we describe the discovery of a novel class of oxadiazole derivatives from which potent and selective CB2 agonist leads were developed. Initial hit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c877b87d7688ce77fe355980c89db7
https://doi.org/10.1021/jm800463f
https://doi.org/10.1021/jm800463f
Publikováno v:
Journal of Neurochemistry. 64:199-205
The serotonin 5-HT 2C receptor (formerly designated the 5-HT 1C receptor) of the choroid plexus triggers phosphoinositide turnover. In the present study, we demonstrate that receptor activation also triggers the formation of cyclic GMP (cGMP). Applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f580957ec007165fad52c9639e9906
https://doi.org/10.1046/j.1471-4159.1995.64010199.x
https://doi.org/10.1046/j.1471-4159.1995.64010199.x
Publikováno v:
Journal of Neurochemistry. 82:336-344
A number of studies in recent years have linked polymorphisms within the serotonin transporter (5HTT) gene to affective disorders and anxiety traits. The human 5HTT mRNA is alternatively spliced, and the splice variants are equally expressed in the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4734101e68c68d2f4fb4bae2b1601b4d
https://doi.org/10.1046/j.1471-4159.2002.00964.x
https://doi.org/10.1046/j.1471-4159.2002.00964.x
Autor:
Anindya Bhattacharya, Marlene L. Cohen, Elizabeth J. Galbreath, Kathryn W. Schenck, Beth J. Hoffman, Danqing Li
Publikováno v:
Receptors and Channels. 8:71-78
Since 5-HT 1 B receptor mRNA was reported in rat aorta, and 5-HT 1 B receptor activation has been linked to vascular contraction, we explored sumatriptan-induced contractility and immunohistochemical density of 5-HT 1 B receptor protein in rat aorta.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e892d5c74077d289f39fed076580c99c
https://doi.org/10.3109/10606820212395
https://doi.org/10.3109/10606820212395
Publikováno v:
Brain Research. 842:239-242
Noradrenergic locus coeruleus (LC) efferents to the forebrain suppress seizures in several models of epilepsy. Using in situ hybridization, we demonstrate that tyrosine hydroxylase (TH) and norepinephrine transporter (NET) but not vesicular monoamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6122682ba9245f873fe2b1a1a80d107
https://doi.org/10.1016/s0006-8993(99)01874-0
https://doi.org/10.1016/s0006-8993(99)01874-0
Publikováno v:
Neuroscience. 89:243-265
A growing body of evidence suggests that serotonin plays an important role in the early development of both neural and non-neural tissues from vertebrate and invertebrate species. Serotonin is removed from the extracellular space by the cocaine- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9e1d568fa6be19a830fe0a8be23f1f
https://doi.org/10.1016/s0306-4522(98)00281-4
https://doi.org/10.1016/s0306-4522(98)00281-4
Publikováno v:
Developmental Brain Research. 111:305-314
The serotonin transporter MRNA has been found throughout the trigeminal sensory system late in gestation and during early postnatal development, a period known to be critical for maturation of the sensory circuitry. The purpose of the present study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8965a307c248cef72c3a498e5a291a93
https://doi.org/10.1016/s0165-3806(98)00148-5
https://doi.org/10.1016/s0165-3806(98)00148-5
Autor:
Beth Borowsky, Beth J. Hoffman
Publikováno v:
Journal of Biological Chemistry. 273:29077-29085
The rat GLYT-1 gene encodes two glycine transporter variants, GLYT-1a and GLYT-1b, that differ in NH2 termini and 5'-noncoding regions as well as in tissue distribution. The GLYT-1 gene contains 15 exons, with the first two specific for GLYT-1a and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3c6c119c43d0b9b84f0bf6177e23a8
https://doi.org/10.1074/jbc.273.44.29077
https://doi.org/10.1074/jbc.273.44.29077
Publikováno v:
Developmental Brain Research. 110:135-158
We used in situ hybridization histochemistry to study the expression of the mRNA of the two vesicular monoamine transporters (VMAT1 and VMAT2) during embryonic and postnatal development of the central nervous system (CNS) in the rat. In the adult rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2569edff62979faac41110285c50eeab
https://doi.org/10.1016/s0165-3806(98)00104-7
https://doi.org/10.1016/s0165-3806(98)00104-7
Autor:
Eva Mezey, Ignazio Castagliuolo, Chi-Chung Wang, Charalabos Pothoulakis, Hanzong Li, Beth J. Hoffman, Susan E. Leeman
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 275:G68-G75
We previously reported that the inflammatory effects of Clostridium difficile toxin A on rat intestine can be significantly inhibited with a specific neurokinin-1 receptor (NK-1R) antagonist. In this study we investigated the localization and express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785c193dfdc113146f00948bcd440be7
https://doi.org/10.1152/ajpgi.1998.275.1.g68
https://doi.org/10.1152/ajpgi.1998.275.1.g68