Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Beth B. Pinney"'
Autor:
Namal Chithranga Warshakoon, Beth B. Pinney, Ofer Reizes, Nick K. Kim, Justin Sheville, Chrissy Mitchell, José Méndez-Andino, X. Eric Hu, Jennifer L. Paris, John August Wos, Ritu Tiku Bhatt, Wei Ji, Kenneth M. Meyers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5207-5211
A novel series of substituted quinoline analogs were designed and synthesized as potent and selective melanin concentrating hormone (MCH) antagonists. These analogs show potent (nM) activity (12a-k) with a moderate selectivity. Conversely, the confor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63414ec00add49c8dc48a46f38fcb17
https://doi.org/10.1016/j.bmcl.2006.07.006
https://doi.org/10.1016/j.bmcl.2006.07.006
Autor:
Julie A. Farmer, Adrian Gregory Switzer, Martin E. Dowty, Timothy B. Field, Adam W. Mazur, Xinrong Tian, Russell James Sheldon, Beth B. Pinney, Steve Berberich, Lalith R. Jayasinghe, Frank H. Ebetino, Doreen Crossdoersen, John August Wos, Cindy Obringer
Publikováno v:
Journal of Medicinal Chemistry. 49:4745-4761
The design, synthesis, and structure-activity relationships (SAR) of a series of novel proline and pyrrolidine based melanocortin receptor (MCR) agonists are described. To validate a conformationally constrained Arg-Nal dipeptide analogue strategy, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c13dd0d81d8232511803d1ceb5b3a8d
https://doi.org/10.1021/jm060384p
https://doi.org/10.1021/jm060384p
Autor:
Beth B. Pinney, Jeffery C. Hayes, Xinrong Tian, Russell James Sheldon, Mark Gregory Solinsky, Adrian Gregory Switzer, Frank H. Ebetino, Doreen Crossdoersen, John August Wos, Julie A. Farmer, Xuemei Chen, Lixian Gan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1721-1725
The first synthesis of Tic-D-Phe Psi[CH(2)-CH(2)] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f2e272b4df8d3a15260f691f187f61
https://doi.org/10.1016/j.bmcl.2005.12.005
https://doi.org/10.1016/j.bmcl.2005.12.005
Autor:
Russell James Sheldon, Frank H. Ebetino, Doreen Crossdoersen, Beth B. Pinney, Timothy B. Field, John August Wos, Adam W. Mazur, Xinrong Tian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2819-2823
A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d98be2223eb0fbcce5b4ccf24d34b93
https://doi.org/10.1016/j.bmcl.2005.03.120
https://doi.org/10.1016/j.bmcl.2005.03.120
Autor:
Frank H. Ebetino, Doreen Crossdoersen, Lily Dong, Mark E. Webster, Beth B. Pinney, Russell James Sheldon, Adrian Gregory Switzer, Cindy Obringer, Mumin Rashid Naeem, Lalith R. Jayasinghe, Anny-Odile Colson, Rajesh K. Mishra, Charles A. Cruze, John August Wos, Steve A. Derose, Mark Gregory Solinsky, Martin E. Dowty, Paula M. Suchanek, Xinrong Tian, Julie A. Farmer, Melissa L. Burklow, Mary Kay Dirr
Publikováno v:
Journal of medicinal chemistry. 51(19)
A study that was designed to identify plausible replacements for highly basic guanidine moiety contained in potent MC4R agonists, as exemplified by 1, led to the discovery of initial nonguanidine lead 5. Propyl analog 23 was subsequently found to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e52a7fe340a9c83c2c7be10d428b58
https://pubmed.ncbi.nlm.nih.gov/18771254
https://pubmed.ncbi.nlm.nih.gov/18771254
Autor:
M. Chrissy Mitchell, X. Eric Hu, Nick K. Kim, Namal Chithranga Warshakoon, Anny-Odile Colson, Kenneth M. Meyers, Beth B. Pinney, Wei Ji, José Méndez-Andino, Jan Richard Davis, John August Wos, Ofer Reizes
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(20)
A substituted 4-aminopiperidine was identified as showing activity in an MCH assay from an HTS effort. Subsequent structural modification of the scaffold led to the identification of a number of active MCH antagonists. 3,5-Dimethoxy-N-(1-(naphthalen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4069f5dd041093e9be16eaeffaff888c
https://pubmed.ncbi.nlm.nih.gov/16879961
https://pubmed.ncbi.nlm.nih.gov/16879961
Autor:
Adam W. Mazur, Russell James Sheldon, Nick K. Kim, Julie A. Farmer, Xinrong Tian, John August Wos, Frank H. Ebetino, Doreen Crossdoersen, X. Eric Hu, Adrian Gregory Switzer, Rajesh K. Mishra, Beth B. Pinney
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(17)
The design and synthesis of a series of potent 1,3,4-trisubstituted-2-oxopiperazine based MC4 agonists are described. The tripeptidomimetic analogs (12a,b and 23) and the dipeptidomimetic 27 displayed single-nanomolar binding affinity and agonist pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4afe7785f394889d87bf23f1b6b7cc9
https://pubmed.ncbi.nlm.nih.gov/16766182
https://pubmed.ncbi.nlm.nih.gov/16766182
Autor:
Xinrong Tian, John A. Wos, Adrian G. Switzer, Steve A. Derose, Rajesh K. Mishra, Mark G. Solinsky, Rashid N. Mumin, Frank H. Ebetino, Lalith R. Jayasinghe, Mark E. Webster, Anny-Odile Colson, Doreen Crossdoersen, Beth B. Pinney, Julie A. Farmer, Martin E. Dowty, Cindy M. Obringer, Charles A. Cruze, Melissa L. Burklow, Paula M. Suchanek, Lily Dong
Publikováno v:
Journal of Medicinal Chemistry; Sep2008, Vol. 51 Issue 19, p6055-6066, 12p