Výsledky vyhledávání - "Betaine reductase"

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Metagenomic data-mining reveals enrichment of trimethylamine-N-oxide synthesis in gut microbiome in atrial fibrillation patients

Autor: Xiandong Yin, Jie Jiao, Pan Wang, Xinchun Yang, Kun Zuo, Zheng Liu, Jing Li, Xiaoqing Liu, Chunming Han

Publikováno v: BMC Genomics, Vol 21, Iss 1, Pp 1-9 (2020)
BMC Genomics

Background The gut bacteria-derived metabolite trimethylamine-N-oxide (TMAO) has been discussed in various cardiometabolic diseases. However, evidence characterizing the microbial population responsible for TMAO accumulation in patients with atrial f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5223752f8d65607b270182ec295815b
http://link.springer.com/article/10.1186/s12864-020-06944-w

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Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi

Autor: Yi Tang, Arthur J Huang, Yang Hai

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 21

Nonribosomal peptide synthetases (NRPS) and NRPS-like enzymes have diverse functions in primary and secondary metabolism. By using a structure-guided approach, we uncovered the function of an NRPS-like enzyme with unusual domain architecture, catalyz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b2a6fdff75d6db1f7345427cdb8bc5
https://escholarship.org/uc/item/2c30s6cz

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Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia

Autor: Silke Rath, Tatjana Rud, Dietmar H. Pieper, Marius Vital

Publikováno v: Frontiers in Microbiology
Frontiers in microbiology
Frontiers in Microbiology, Vol 10 (2020)

Human gut bacteria metabolize dietary components such as choline and carnitine to trimethylamine (TMA) that is subsequently oxidized to trimethylamine-N-oxide (TMAO) by hepatic enzymes. Increased plasma levels of TMAO are associated with the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ecaa1bb5ed127f342346629d3aac3f
http://europepmc.org/articles/PMC6964529

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Purification and characterization of protein PB of betaine reductase and its relationship to the corresponding proteins glycine reductase and sarcosine reductase from Eubacterium acidaminophilum

Autor: Katrin Granderath, Jan R. Andreesen, Manfred Meyer

Publikováno v: European journal of biochemistry. 234(1)

Simple complementation assay systems were developed for the substrate-specific proteins PB of glycine reductase, sarcosine reductase, and betaine reductase, in which acetyl phosphate was detected as the product in all three cases. The betaine-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d0219bd751f53ec02839fb502e2dd0
https://pubmed.ncbi.nlm.nih.gov/8529639

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Substrate-specific selenoprotein B of glycine reductase from Eubacterium acidaminophilum. Biochemical and molecular analysis

Autor: Andreas Pich, Matthias Wagner, Denise Sonntag, Brigitte Söhling, Christoph Eckerskorn, Rudolf Grimm, Jan R. Andreesen

Publikováno v: European journal of biochemistry. 260(1)

The substrate-specific selenoprotein B of glycine reductase (PBglycine) from Eubacterium acidaminophilum was purified and characterized. The enzyme consisted of three different subunits with molecular masses of about 22 (alpha), 25 (beta) and 47 kDa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d138c2d29d7e83ceeb3fbb2ea237e7f
https://pubmed.ncbi.nlm.nih.gov/10091582

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Betaine: New Oxidant in the Stickland Reaction and Methanogenesis from Betaine and l -Alanine by a Clostridium sporogenes-Methanosarcina barkeri Coculture

Autor: Gerhard Gottschalk, Evelyn Naumann, Hans Hippe

Publikováno v: Applied and Environmental Microbiology. 45:474-483

Growing and nongrowing cells of Clostridium sporogenes fermented betaine with l -alanine, l -valine, l -leucine, and l -isoleucine as electron donors in a coupled oxidation-reduction reaction (Stickland reaction). For the substrate combinations betai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1e18a8bc3cc12f807596c28f95c642
https://doi.org/10.1128/aem.45.2.474-483.1983

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Reductive cleavage of sarcosine and betaine by Eubacterium acidaminophilum via enzyme systems different from glycine reductase

Autor: K. Hormann, Jan R. Andreesen

Publikováno v: Archives of Microbiology. 153:50-59

The obligate anaerobe Eubacterium acidaminophilum metabolized the glycine derivatives sarcosine (N-monomethyl glycine) and betaine (N-trimethyl glycine) only by reduction in a reaction analogous to glycine reductase. Using formate as electron donor,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4a2466d228a0cc180845529b6e64ce3
https://doi.org/10.1007/bf00277541

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