The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions.

Autor: Mara Baldry, Betül Kitir, Hanne Frøkiær, Simon B Christensen, Nico Taverne, Marjolein Meijerink, Henrik Franzyk, Christian A Olsen, Jerry M Wells, Hanne Ingmer

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0145618 (2016)

Staphylococcus aureus infections are becoming increasingly difficult to treat due to antibiotic resistance with the community-associated methicillin-resistant S. aureus (CA-MRSA) strains such as USA300 being of particular concern. The inhibition of b

Externí odkaz: https://doaj.org/article/69bb60bc987d46abba5415f1df43390d

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

Autor: Douglas B. Fox, Matthew D. Hirschey, Paul A. Grimsrud, Olga Ilkayeva, Scott B. Crown, Christian A. Olsen, Eoin McDonnell, Betül Kitir

Publikováno v: Cell Reports, Vol 17, Iss 6, Pp 1463-1472 (2016)

SummaryCells integrate nutrient sensing and metabolism to coordinate proper cellular responses to a particular nutrient source. For example, glucose drives a gene expression program characterized by activating genes involved in its metabolism, in par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c733d641bad7c12557ac65c7061849f8
http://www.sciencedirect.com/science/article/pii/S2211124716313985

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions

Autor: Jerry M. Wells, Christian A. Olsen, Hanne Frøkiær, Henrik Franzyk, Betül Kitir, Marjolein Meijerink, Simon Bendt Christensen, Nico Taverne, Mara Baldry, Hanne Ingmer

Publikováno v: PLoS ONE, 11(1)
PLoS ONE 11 (2016) 1
PLoS ONE, Vol 11, Iss 1, p e0145618 (2016)
Baldry, M, Kitir, B, Frøkiær, H, Christensen, S B, Taverne, N, Meijerink, M, Franzyk, H, Olsen, C A, Wells, J M & Ingmer, H 2016, ' The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions ', P L o S One, vol. 11, no. 1, e0145618 . https://doi.org/10.1371/journal.pone.0145618
PLoS ONE

Staphylococcus aureus infections are becoming increasingly difficult to treat due to antibiotic resistance with the community-associated methicillin-resistant S. aureus (CA-MRSA) strains such as USA300 being of particular concern. The inhibition of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e42df9d2e136474d4cf1d9d9cfd4de7
https://research.wur.nl/en/publications/the-agr-inhibitors-solonamide-b-and-analogues-alter-immune-respon

An azumamide C analogue without the zinc-binding functionality

Autor: Betül Kitir, Jesper Villadsen, Tina Friis, Christian A. Olsen, Andreas Stahl Madsen, Kathrine Wich

Publikováno v: Villadsen, J, Kitir, B, Wich, K, Friis, T, Madsen, A S & Olsen, C A 2014, ' An azumamide C analogue without the zinc-binding functionality ', MedChemComm, vol. 5, pp. 1849-1855 . https://doi.org/10.1039/C4MD00252K

Histone deacetylase (HDAC) inhibitors have attracted considerable attention due to their promise as therapeutic agents. Most HDAC inhibitors adhere to a general “ cap-linker-Zn 2+ -binding group ” architecture but recent studies have indicated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04808be18ea5e0c6cb1d1b9b15962c0e
https://orbit.dtu.dk/en/publications/7b44e82b-f3d2-4094-96f8-6d810fd8dd25