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Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122.

Autor: Chai C; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Cox B; Laboratory of Biochemical Pharmacology Emory University, Department of Pediatrics, Atlanta, Georgia., Yaish D; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Gross D; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Rosenberg N; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Amblard F; Laboratory of Biochemical Pharmacology Emory University, Department of Pediatrics, Atlanta, Georgia., Shemuelian Z; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Gefen M; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Korach A; Cardiothoracic Surgery, Hadassah Hebrew University Hospital, Jerusalem, Israel., Tirosh O; Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot, Israel., Lanton T; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Link H; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Tam J; Obesity and Metabolism Laboratory, Multidisciplinary Center for Cannabinoid Research, Faculty of Medicine, The Institute for Drug Research, The Hebrew University of Jerusalem, Israel., Permyakova A; Obesity and Metabolism Laboratory, Multidisciplinary Center for Cannabinoid Research, Faculty of Medicine, The Institute for Drug Research, The Hebrew University of Jerusalem, Israel., Ozhan G; Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey., Citrin J; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Liao H; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Tannous M; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Hahn M; Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot, Israel., Axelrod J; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Arretxe E; OWL Metabolomics, Bizkaia Technology Park, Derio, Spain., Alonso C; OWL Metabolomics, Bizkaia Technology Park, Derio, Spain., Martinez-Arranz I; OWL Metabolomics, Bizkaia Technology Park, Derio, Spain., Betés PO; OWL Metabolomics, Bizkaia Technology Park, Derio, Spain., Safadi R; Liver Unit, Gastroenterology Institute, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Salhab A; Liver Unit, Gastroenterology Institute, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Amer J; Liver Unit, Gastroenterology Institute, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Tber Z; Laboratory of Biochemical Pharmacology Emory University, Department of Pediatrics, Atlanta, Georgia., Mengshetti S; Laboratory of Biochemical Pharmacology Emory University, Department of Pediatrics, Atlanta, Georgia., Giladi H; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel., Schinazi RF; Laboratory of Biochemical Pharmacology Emory University, Department of Pediatrics, Atlanta, Georgia. Electronic address: raymond.schinazi@emory.edu., Galun E; Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel. Electronic address: eithang@hadassah.org.il.

Publikováno v: Gastroenterology [Gastroenterology] 2020 Sep; Vol. 159 (3), pp. 999-1014.e9. Date of Electronic Publication: 2020 May 22.