Crystal structure of the GDP-bound human M-RAS protein in two crystal forms.

Autor: Bester SM; Pfizer Boulder Research and Development, 3200 Walnut Street, Boulder, CO 80301, USA., Abrahamsen R; Pfizer Boulder Research and Development, 3200 Walnut Street, Boulder, CO 80301, USA., Rodrigues Samora L; Pfizer Boulder Research and Development, 3200 Walnut Street, Boulder, CO 80301, USA., Wu WI; Pfizer Boulder Research and Development, 3200 Walnut Street, Boulder, CO 80301, USA., Mou TC; Pfizer Boulder Research and Development, 3200 Walnut Street, Boulder, CO 80301, USA.

Publikováno v: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2024 Sep 01; Vol. 80 (Pt 9), pp. 220-227. Date of Electronic Publication: 2024 Aug 28.

Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.

Autor: Bester SM; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA., Adu-Ampratwum D; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA., Annamalai AS; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA., Wei G; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA., Briganti L; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA., Murphy BC; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA., Haney R; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA., Kvaratskhelia M; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA.

Publikováno v: MBio [mBio] 2022 Oct 26; Vol. 13 (5), pp. e0180422. Date of Electronic Publication: 2022 Oct 03.

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.

Autor: Bester SM; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Wei G; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Zhao H; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Adu-Ampratwum D; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Iqbal N; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Courouble VV; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA., Francis AC; Department of Pediatrics, Infectious Diseases, Emory University, Atlanta, GA 30322, USA., Annamalai AS; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Singh PK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Shkriabai N; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Van Blerkom P; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Morrison J; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Poeschla EM; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA., Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Melikyan GB; Department of Pediatrics, Infectious Diseases, Emory University, Atlanta, GA 30322, USA., Griffin PR; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Asturias FJ; Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA. mamuka.kvaratskhelia@cuanschutz.edu francisco.asturias@cuanschutz.edu., Kvaratskhelia M; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA. mamuka.kvaratskhelia@cuanschutz.edu francisco.asturias@cuanschutz.edu.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Oct 16; Vol. 370 (6514), pp. 360-364.

Synthesis and Molecular Properties of Nerve Agent Reactivator HLö-7 Dimethanesulfonate.

Autor: Hsu FL; United States Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010, United States., Bae SY; United States Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010, United States., McGuire J; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, United States., Anderson DR; United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010, United States., Bester SM; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, United States., Height JJ; United States Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010, United States., Pegan SD; United States Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010, United States.; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, United States.; United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010, United States., Walz AJ; United States Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Mar 28; Vol. 10 (5), pp. 761-766. Date of Electronic Publication: 2019 Mar 28 (Print Publication: 2019).

Insights into the Porcine Reproductive and Respiratory Syndrome Virus Viral Ovarian Tumor Domain Protease Specificity for Ubiquitin and Interferon Stimulated Gene Product 15.

Autor: Bester SM; Department of Pharmaceutical and Biomedical Sciences , University of Georgia , Athens , Georgia 30602 , United States., Daczkowski CM; Department of Pharmaceutical and Biomedical Sciences , University of Georgia , Athens , Georgia 30602 , United States., Faaberg KS; Virus and Prion Research Unit , USDA-ARS-National Animal Disease Center , Ames , Iowa 50010 , United States., Pegan SD; Department of Pharmaceutical and Biomedical Sciences , University of Georgia , Athens , Georgia 30602 , United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2018 Sep 14; Vol. 4 (9), pp. 1316-1326. Date of Electronic Publication: 2018 Jun 12.