Species-specific inflammatory responses as a primary component for the development of glomerular lesions in mice and monkeys following chronic administration of a second-generation antisense oligonucleotide.

Autor: Frazier KS; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA kendall.s.frazier@gsk.com., Sobry C; CiToxLab, Evreux, France., Derr V; Pathology, Microbiology and Immunology, University of California-Davis, California, USA., Adams MJ; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom., Besten CD; Prosensa Therapeutics, Leiden, The Netherlands., De Kimpe S; Prosensa Therapeutics, Leiden, The Netherlands., Francis I; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom., Gales TL; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA., Haworth R; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom., Maguire SR; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom., Mirabile RC; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA., Mullins D; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA., Palate B; CiToxLab, Evreux, France., Doorten YP; Prosensa Therapeutics, Leiden, The Netherlands., Ridings JE; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom., Scicchitano MS; Department of Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania, USA., Silvano J; CiToxLab, Evreux, France., Woodfine J; Departments of Safety Assessment and Scinovo, GlaxoSmithKline, Ware, United Kingdom.

Publikováno v: Toxicologic pathology [Toxicol Pathol] 2014 Jul; Vol. 42 (5), pp. 923-35. Date of Electronic Publication: 2013 Nov 28.