Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Bess Frost"'
Autor:
Heather E. Whitson, William A. Banks, Monica M. Diaz, Bess Frost, Manolis Kellis, Richard Lathe, Kenneth E. Schmader, Serena S. Spudich, Rudolph Tanzi, Gwenn Garden
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 36, Iss , Pp 100743- (2024)
Alzheimer's disease (AD) involves a complex pathological process that evolves over years, and its etiology is understood as a classic example of gene-environment interaction. The notion that exposure to microbial organisms may play some role in AD pa
Externí odkaz:
https://doaj.org/article/a8b84dfe6a364ca4aa96dc21a9e45b62
Autor:
Adrian Beckmann, Paulino Ramirez, Maria Gamez, Elias Gonzalez, Jasmine De Mange, Kevin F. Bieniek, William J. Ray, Bess Frost
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106152- (2023)
Summary: In Alzheimer’s disease, neurons acquire phenotypes that are also present in various cancers, including aberrant activation of the cell cycle. Unlike cancer, cell cycle activation in post-mitotic neurons is sufficient to induce cell death.
Externí odkaz:
https://doaj.org/article/5965e057071d4ba79c8f4735a9a83cf8
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Neurodegenerative tauopathies, including Alzheimer’s disease, are pathologically defined by the presence of aggregated forms of tau protein in brains of affected individuals. Previous studies report that the negative effects of pathogenic tau on th
Externí odkaz:
https://doaj.org/article/660ed201abe5442da281023381a84c62
Publikováno v:
Cell Reports: Methods, Vol 2, Iss 9, Pp 100292- (2022)
Summary: Tau protein aggregates are a defining neuropathological feature of “tauopathies,” a group of neurodegenerative disorders that include Alzheimer’s disease. In the current study, we develop a Drosophila split-luciferase-based sensor of t
Externí odkaz:
https://doaj.org/article/f7d9edc9e434404193eb6b5988e2cd67
Autor:
Rebekah Mahoney, Elizabeth Ochoa Thomas, Paulino Ramirez, Henry E. Miller, Adrian Beckmann, Gabrielle Zuniga, Radek Dobrowolski, Bess Frost
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107900- (2020)
Summary: Synaptic activity-induced calcium (Ca2+) influx and subsequent propagation into the nucleus is a major way in which synapses communicate with the nucleus to regulate transcriptional programs important for activity-dependent survival and memo
Externí odkaz:
https://doaj.org/article/56b011e43a4a48ce9382dc8da7a8ee66
Publikováno v:
Neuroscience. 518:101-111
Alzheimer's disease and other tauopathies are neurodegenerative disorders pathologically defined by aggregated forms of tau protein in the brain. While synaptic degradation is a well-established feature of tau-induced neurotoxicity, the underlying me
Autor:
Henry E Miller, Daniel Montemayor, Janet Li, Simon A Levy, Roshan Pawar, Stella Hartono, Kumar Sharma, Bess Frost, Frédéric Chedin, Alexander J R Bishop
Publikováno v:
Nucleic Acids Research. 51:D1129-D1137
R-loops are three-stranded nucleic acid structures formed from the hybridization of RNA and DNA. In 2012, Ginno et al. introduced the first R-loop mapping method. Since that time, dozens of R-loop mapping studies have been conducted, yielding hundred
Autor:
Henry E Miller, Daniel Montemayor, Jebriel Abdul, Anna Vines, Simon A Levy, Stella R Hartono, Kumar Sharma, Bess Frost, Frédéric Chédin, Alexander J R Bishop
Publikováno v:
Nucleic Acids Research. 50:7260-7286
R-loops are three-stranded nucleic acid structures formed from the hybridization of RNA and DNA. While the pathological consequences of R-loops have been well-studied to date, the locations, classes, and dynamics of physiological R-loops remain poorl
Autor:
Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J. Ray, Kevin F. Bieniek, Bess Frost
Publikováno v:
Science advances. 9(1)
Deposition of tau protein aggregates in the brain of affected individuals is a defining feature of “tauopathies,” including Alzheimer’s disease. Studies of human brain tissue and various model systems of tauopathy report that toxic forms of tau
Autor:
Shiva Kazempour Dehkordi, Jamie Walker, Eric Sah, Emma Bennett, Farzaneh Atrian, Bess Frost, Benjamin Woost, Rachel E. Bennett, Timothy C. Orr, Yingyue Zhou, Prabhakar S. Andhey, Marco Colonna, Peter H. Sudmant, Peng Xu, Minghui Wang, Bin Zhang, Habil Zare, Miranda E. Orr
Publikováno v:
Nat Aging
Senescent cells contribute to pathology and dysfunction in animal models(1). Their sparse distribution and heterogenous phenotype have presented challenges for detecting them in human tissues. We developed a senescence eigengene approach to identify