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Positive Diagnosis of Ancient Leprosy and Tuberculosis Using Ancient DNA and Lipid Biomarkers

Autor: Donoghue, H, Taylor, G, Stewart, Graham, Lee, O, Wu, H, Besra, G, Minnikin, D

Diagnosis of leprosy and tuberculosis in archaeological material is most informative when based upon entire genomes. Ancient DNA (aDNA) is often degraded but amplification of specific fragments also provides reliable diagnoses. Cell wall lipid biomar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______305::964a5ab45aff58fea843bb4e9661379c
https://surrey.eprints-hosting.org/846049/

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Non-glycosidic compounds can stimulate both human and mouse iNKT cells

Autor: Jukes, J, Gileadi, U, Ghadbane, H, Yu, T, Shepherd, D, Cox, L, Besra, G, Cerundolo, V

Publikováno v: European journal of immunology.

Invariant natural killer T (iNKT) cells recognize CD1d/glycolipid complexes and upon activation with synthetic agonists display immunostimulatory properties. We have previously described that the non-glycosidic CD1d-binding lipid, threitolceramide (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5f39858d68eb9dcf878818d0f052812f
http://ora.ox.ac.uk/objects/uuid:6c1f9a15-7f79-4f62-bfd7-aac9e2aa8b93

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Akademický článek

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Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C

Publikováno v: European journal of immunology. 42(7)

Invariant natural killer T (iNKT) cells are a specialised subset of T cells that are restricted to the MHC class I like molecule, CD1d. The ligands for iNKT cells are lipids, with the canonical superagonist being α-galactosylceramide, a non-mammalia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ab22a5557cce6476c1aa4f93c4b4b0b1
https://pubmed.ncbi.nlm.nih.gov/22585405

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Crystal structure of bovine CD1b3 with endogenously bound ligands

Autor: Girardi, E., Wang, J., Mac, T.T., Versluis, C., Bhowruth, V., Besra, G., Heck, A.J.R., van Rhijn, I., Zajonc, D.M., Biomolecular Mass Spectrometry and Proteomics, Strategic Infection Biology, Sub Biomol.Mass Spectrometry & Proteom., Sub Biomol.Mass Spect. and Proteomics, Dep Infectieziekten Immunologie

Publikováno v: Journal of Immunology, 185, 376. American Association of Immunologists

The CD1 family of Ag-presenting molecules is able to display lipids to T cells by binding them within a hydrophobic groove connected to the protein surface. In particular, the CD1b isotype is capable of binding ligands with greatly varying alkyl chai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab73a2fe4072cd44c2ce8a9a4325a44
https://dspace.library.uu.nl/handle/1874/202902

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Biomolecular archaeology of ancient tuberculosis: response to 'Deficiencies and challenges in the study of ancient tuberculosis DNA' by Wilbur et al. (2009)

Autor: Donoghue, H. D., Hershkovitz, I., Minnikin, D. E., Besra, G. S., Lee, O. Y. C., Galili, E., Greenblatt, C. L., Lemma, E., Spigelman, M., Bar-Gal, G. K.

Publikováno v: J ARCHAEOL SCI, 36 (12) 2797-2804. (2009)

It is sixteen years since the first detection of Mycobacterium tuberculosis DNA in archaeological specimens, yet the validity of findings continues to be questioned. Rigorous scientific scrutiny and debate is valuable and has led to a coalescence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______322::766b31f4186522473022718105dda0d6
https://discovery.ucl.ac.uk/id/eprint/18166/1/18166.pdf

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