Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

Autor: Durdagi, Serdar, Dağ, Çağdaş, Dogan, Berna, Yigin, Merve, Avsar, Timucin, Buyukdag, Cengizhan, Erol, Ismail, Ertem, Fatma Betul, Calis, Seyma, Yildirim, Gunseli, Orhan, Muge D., Guven, Omur, Aksoydan, Busecan, Destan, Ebru, Sahin, Kader, Besler, Sabri O., Oktay, Lalehan, Shafiei, Alaleh, Tolu, Ilayda, Ayan, Esra, Yuksel, Busra, Peksen, Ayse B., Gocenler, Oktay, Yucel, Ali D., Can, Ozgur, Ozabrahamyan, Serena, Olkan, Alpsu, Erdemoglu, Ece, Aksit, Fulya, Tanisali, Gokhan, Yefanov, Oleksandr M., Barty, Anton, Tolstikova, Alexandra, Ketawala, Gihan K., Botha, Sabine, Dao, E. Han, Hayes, Brandon, Liang, Mengning, Seaberg, Matthew H., Hunter, Mark S., Batyuk, Alex, Mariani, Valerio, Su, Zhen, Poitevin, Frederic, Yoon, Chun Hong, Kupitz, Christopher, Sierra, Raymond G., Snell, Edward H., DeMirci, Hasan

Publikováno v: In Structure 2 December 2021 29(12):1382-1396

Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein.

Autor: Ciftci H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.; Department of Drug Discovery, Science Farm Ltd, Kumamoto, 862-0976, Japan.; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Koiwai K; Structural Biology Research Center, Institute of Materials Structure Science, KEK/High Energy Accelerator Research Organization, Tsukuba, Ibaraki, 305-0801, Japan., Koga R; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Anraku K; Department of Medical Technology, Kumamoto Health Science University, Kumamoto, 861-5598, Japan., Monde K; Department of Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan., Dağ Ç; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.; Department of Molecular Biology and Genetics, Koc University, 34450, Istanbul, Turkey., Destan E; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA., Yuksel B; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA., Ayan E; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA., Yildirim G; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA., Yigin M; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA., Ertem FB; Department of Molecular Biology and Genetics, Koc University, 34450, Istanbul, Turkey., Shafiei A; Department of Molecular Biology and Genetics, Koc University, 34450, Istanbul, Turkey., Guven O; Department of Molecular Biology and Genetics, Koc University, 34450, Istanbul, Turkey., Besler SO; Department of Molecular Biology and Genetics, Koc University, 34450, Istanbul, Turkey., Sierra RG; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Yoon CH; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Su Z; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.; Department of Applied Physics, Stanford University, Stanford, CA, USA., Liang M; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Acar B; Polymer Research Center, Bogazici University, 34342, Istanbul, Turkey., Haliloglu T; Department of Chemical Engineering, Bogazici University, 34342, Istanbul, Turkey.; Polymer Research Center, Bogazici University, 34342, Istanbul, Turkey., Otsuka M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.; Department of Drug Discovery, Science Farm Ltd, Kumamoto, 862-0976, Japan., Yumoto F; Structural Biology Research Center, Institute of Materials Structure Science, KEK/High Energy Accelerator Research Organization, Tsukuba, Ibaraki, 305-0801, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan. mfujita@kumamoto-u.ac.jp., Senda T; Structural Biology Research Center, Institute of Materials Structure Science, KEK/High Energy Accelerator Research Organization, Tsukuba, Ibaraki, 305-0801, Japan. toshiya.senda@kek.jp.; School of High Energy Accelerator Science, SOKENDAI University, Tsukuba, Ibaraki, 305-0801, Japan. toshiya.senda@kek.jp.; Faculty of Pure and Applied Sciences, University of Tsukuba, Ibaraki, 305-8571, Japan. toshiya.senda@kek.jp., DeMirci H; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA. hdemirci@stanford.edu.; Department of Molecular Biology and Genetics, Koc University, 34450, Istanbul, Turkey. hdemirci@stanford.edu.; Koc University Isbank Center for Infectious Diseases (KUISCID), 34450, Istanbul, Turkey. hdemirci@stanford.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Aug 04; Vol. 11 (1), pp. 15819. Date of Electronic Publication: 2021 Aug 04.