Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Besik Kankia"'
Autor:
Besik Kankia
Publikováno v:
Biology Direct, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Background The RNA world hypothesis cannot address most of the questions of the origin of life without violating the continuity principle (small Darwinian steps without foresight and miracles). Moreover, the RNA world is an isolated system i
Externí odkaz:
https://doaj.org/article/f164fbec1a094401985f1df7a5ebcb5f
Autor:
Levan Lomidze, Mengkun Yang, David Khutsishvili, Nunu Metreveli, Karin Musier-Forsyth, Besik Kankia
Publikováno v:
ACS Omega, Vol 7, Iss 5, Pp 4311-4316 (2022)
Externí odkaz:
https://doaj.org/article/6960ebc6a8ce408a9610745858a6b7f7
Autor:
Besik, Kankia
Publikováno v:
Origins of Life and Evolution of Biospheres. 51:273-286
The RNA world hypothesis relies on the double-helix complementarity principle for both replication and catalytic activity of RNA. However, the de novo appearance of the complementarity rules, without previous evolution steps, is doubtful. Another maj
Autor:
Besik Kankia
Publikováno v:
ChemBioChem. 22:1261-1267
Template-guided chemical reactions between nucleic acid strands are an important process in biomedical research. However, almost all of these reactions employ an oligonucleotide-templated approach that is based on the double-helix alignment. The mode
Autor:
Besik Kankia
Publikováno v:
The Journal of Physical Chemistry B. 124:4263-4269
The stringent base-pairing rules of DNA make it an exceptionally powerful bottom-up nanoscale material for dynamic nanotechnologies. However, current nanomachines are based on rearrangements between DNA duplexes, which limits structural versatility a
Publikováno v:
Biophys Chem
The U3 promoter region of the HIV-1 long terminal repeat (LTR) has previously been shown to fold into a series of dynamic G-quadruplex structures. Among the G-quadruplexes identified in the LTR sequence, LTR-III was shown to be the most stable in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdccadeb9a5c02028bfb0b484f7453e8
https://europepmc.org/articles/PMC8051326/
https://europepmc.org/articles/PMC8051326/
Publikováno v:
Analytical Methods. 10:2972-2979
Amplification of long DNA segments with the highest possible specificity and lowest bias is one of the main goals of modern genomics. Quadruplex priming amplification (QPA) is a single-primer isothermal method, which employs the free energy of quadru
Autor:
Besik Kankia
Publikováno v:
The journal of physical chemistry. B. 123(5)
One of the most stable quadruplexes is formed by the G3T sequence (GGGTGGGTGGGTGGG) that folds into a parallel quadruplex with three G-tetrads and chain-reversal T-loops. For example, in 1 mM K+, it unfolds at 75 °C and at physiological conditions,
Autor:
Karin Musier-Forsyth, Nunu Metreveli, Sean Kelley, Levan Lomidze, Besik Kankia, Shota Gogichaishvili
Publikováno v:
Biopolymers. 105:811-818
Guanine-rich sequences are able to form quadruplexes consisting of G-quartet structural units. Quadruplexes play an important role in the regulation of gene expression and have therapeutic and biotechnological potential. The HIV-1 integrase inhibitor
Autor:
Besik Kankia
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
The G3TG3TG3TG3 (G3T) sequence folds into a monomolecular quadruplex with all-parallel G3 segments connected to each other by chain-reversal loops. The homopolymer consisting of n number of G3T domains directly conjugated to each other folds into an