Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Beshay N"'
Autor:
Mohamed S. Dabour, Ibrahim Y. Abdelgawad, Bushra Sadaf, Mary R. Daniel, Marianne K.O. Grant, Davis Seelig, Beshay N. Zordoky
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117288- (2024)
Irreversible cardiotoxicity limits the clinical application of doxorubicin (DOX). DOX-induced cardiotoxicity has been associated with induction of senescence and activation of the p38 MAPK pathway. Losmapimod (LOSM), an orally active p38 MAPK inhibit
Externí odkaz:
https://doaj.org/article/ea53e7e02ad54a2c88aa1e3da205cda3
Publikováno v:
Antioxidants, Vol 13, Iss 6, p 671 (2024)
Carfilzomib is an irreversible proteasome inhibitor used for multiple myeloma patients. However, carfilzomib treatment is associated with cardiovascular complications. Empagliflozin, an Sodium Glucose Co-transporter 2 inhibitor (SGLT-2) inhibitor, is
Externí odkaz:
https://doaj.org/article/1a14d87c23204f75835e1d182ba538fc
Autor:
Mohamed S. Dabour, Ibrahim Y. Abdelgawad, Marianne K.O. Grant, Engie S. El-Sawaf, Beshay N. Zordoky
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114907- (2023)
Carfilzomib (CFZ) is a proteasome inhibitor approved for relapsed/refractory multiple myeloma (MM) but its clinical use is limited by cardiovascular toxicity. The mechanisms of CFZ-induced cardiovascular toxicity are not fully understood but endothel
Externí odkaz:
https://doaj.org/article/835681aea5364cf1a2da5944f8ea9ab4
Autor:
Ibrahim Y. Abdelgawad, Kevin Agostinucci, Bushra Sadaf, Marianne K. O. Grant, Beshay N. Zordoky
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Introduction: Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial cells (ECs), which contributes to DOX-induced inflammaging. Metformin, an anti
Externí odkaz:
https://doaj.org/article/3e9bb987275342a98f7502970525dca0
Autor:
Marianne K. O. Grant, Maria Razzoli, Ibrahim Y. Abdelgawad, Rachel Mansk, Davis Seelig, Alessandro Bartolomucci, Beshay N. Zordoky
Publikováno v:
Stress, Vol 25, Iss 1, Pp 291-304 (2022)
Childhood cancer survivors have a high risk for premature cardiovascular diseases, mainly due to cardiotoxic cancer treatments such as doxorubicin (DOX). Psychosocial stress is a significant cardiovascular risk factor and an enormous burden in childh
Externí odkaz:
https://doaj.org/article/937f9516f6584ce1aeb6dbce0b53c2c6
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 391 (2023)
Sex is a salient risk factor in the development of doxorubicin-induced cardiotoxicity. Sex differences in the heart’s ability to respond to hypertrophic stimuli in doxorubicin-exposed animals have not been reported. We identified the sexual dimorph
Externí odkaz:
https://doaj.org/article/4832b962dfa9451ebb9c6a1abf8d36cd
Autor:
Kevin Agostinucci, Marianne K. O. Grant, Davis Seelig, Doğacan Yücel, Jop van Berlo, Alessandro Bartolomucci, Jason R. B. Dyck, Beshay N. Zordoky
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Hypertension is the most significant risk factor for heart failure in doxorubicin (DOX)-treated childhood cancer survivors. We previously developed a two-hit mouse model of juvenile DOX-induced latent cardiotoxicity that is exacerbated by adult-onset
Externí odkaz:
https://doaj.org/article/0898dfc3d92b49c9936772f98678f466
Autor:
Ibrahim Y. Abdelgawad, Kevin Agostinucci, Somia G. Ismail, Marianne K. O. Grant, Beshay N. Zordoky
Publikováno v:
Cells, Vol 11, Iss 13, p 1992 (2022)
Doxorubicin (DOX) induces endothelial cell (EC) senescence, which contributes to endothelial dysfunction and cardiovascular complications. Senolytic drugs selectively eliminate senescent cells to ameliorate senescence-mediated pathologies. Previous s
Externí odkaz:
https://doaj.org/article/8c9b283b40fb4b2a85518d987dde1ea5
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0232507 (2020)
Sex-related differences in cardiovascular diseases are highly complex in humans and model-dependent in experimental laboratory animals. The objective of this work was to comprehensively investigate key sex differences in the response to acute and pro
Externí odkaz:
https://doaj.org/article/9c389607ccce4c54a0d1e546329b3138
Clinical and preclinical evidence of sex-related differences in anthracycline-induced cardiotoxicity
Publikováno v:
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-12 (2018)
Abstract Anthracyclines are very effective chemotherapeutic agents that are widely used to treat pediatric and adult cancer patients. Unfortunately, the clinical utility of anthracyclines is limited by cardiotoxicity. There are several established ri
Externí odkaz:
https://doaj.org/article/925b5835dd2a44a395de5892129b16be