Safety assessment of protein A and derivation of a parenteral health-based exposure limit

Autor: Graham, Jessica C., Anand, Sathanandam S., Bercu, Joel, Besenhofer, Lauren, de Zafra, Christina, Feng, Yu, Fisher, Craig, Hillegass, Jedd, Hutchinson, Richard, Jolly, Robert, Moudgal, Chandrika, Nicholas, Tyler, Olszova, Daniela, Schmitz, Matthew, Semmelmann, Florian

Publikováno v: In Regulatory Toxicology and Pharmacology November 2024 153

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.

Autor: Yuda J; National Cancer Center Hospital East, Kashiwa, Japan., Will C; AbbVie Inc, North Chicago, IL, USA., Phillips DC; AbbVie Inc, North Chicago, IL, USA., Abraham L; AbbVie Inc, North Chicago, IL, USA., Alvey C; AbbVie Inc, North Chicago, IL, USA., Avigdor A; Institute of Hematology, Sheba Medical Center, Ramat Gan, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Buck W; AbbVie Inc, North Chicago, IL, USA., Besenhofer L; AbbVie Inc, North Chicago, IL, USA., Boghaert E; AbbVie Inc, North Chicago, IL, USA.; Pleasant Prairie, WI, USA., Cheng D; AbbVie Inc, North Chicago, IL, USA., Cojocari D; AbbVie Inc, North Chicago, IL, USA., Doyle K; AbbVie Inc, North Chicago, IL, USA., Hansen TM; AbbVie Inc, North Chicago, IL, USA., Huang K; AbbVie Inc, North Chicago, IL, USA., Johnson EF; AbbVie Inc, North Chicago, IL, USA., Judd AS; AbbVie Inc, North Chicago, IL, USA., Judge RA; AbbVie Inc, North Chicago, IL, USA., Kalvass JC; AbbVie Inc, North Chicago, IL, USA., Kunzer A; AbbVie Inc, North Chicago, IL, USA., Lam LT; AbbVie Inc, North Chicago, IL, USA., Li R; AbbVie Inc, North Chicago, IL, USA., Martin RL; AbbVie Inc, North Chicago, IL, USA., Mastracchio A; AbbVie Inc, North Chicago, IL, USA., Mitten M; AbbVie Inc, North Chicago, IL, USA.; Beach Park, IL, USA., Petrich A; AbbVie Inc, North Chicago, IL, USA.; Northwestern University, Chicago, IL, USA.; Daiichi Sankyo, Basking Ridge, NJ, USA., Wang J; AbbVie Inc, North Chicago, IL, USA., Ward JE; AbbVie Inc, North Chicago, IL, USA.; Seagen Inc., Bothell, WA, USA., Zhang H; AbbVie Inc, North Chicago, IL, USA., Wang X; AbbVie Inc, North Chicago, IL, USA., Wolff JE; AbbVie Inc, North Chicago, IL, USA.; Replimmune, Puyallop, WA, USA., Bell-McGuinn KM; AbbVie Inc, North Chicago, IL, USA.; Zionsville, IN, USA., Souers AJ; AbbVie Inc, North Chicago, IL, USA. andrew.souers@abbvie.com.

Publikováno v: Communications medicine [Commun Med (Lond)] 2023 Oct 25; Vol. 3 (1), pp. 154. Date of Electronic Publication: 2023 Oct 25.