Výsledky vyhledávání - "Berwyn Clarke"

Autor: Aino Telaranta-Keerie, Berwyn Clarke

Publikováno v: Pharmacogenomics. 13:1453-1457

Pharmacogenetics is essential in the discovery of individual differences in metabolism and response to drugs, as well as in increasing the understanding of disease mechanisms. In addition, the use of biomarker assays is now critical in personalized m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6e91d48dd911bb2a0f6fbb5b5d3aa75
https://doi.org/10.2217/pgs.12.135

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Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease

Autor: Gail Mills, Graham Baker, Paul Jones, Ed Robinson, David M. Andrews, Norman M. Gray, Berwyn Clarke, Susanne S. Bethell, Seb J. Carey, Coomber Ba, George Hardy, Martin John Slater, Andrew Good, Malcolm Ellis, Helene M. Chaignot

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:3359-3362

Using a pyrrolidine-5,5- trans -lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 11a , with an alpha-ethyl P1 substituent and a Boc-valine substituent at the pyrrolidine nitrogen, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d478e26f4966ae307d5b896069c2e2
https://doi.org/10.1016/s0960-894x(02)00789-8

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Molecular genotyping of hepatitis B virus

Autor: Stuart Bloor, Berwyn Clarke

Publikováno v: Journal of Clinical Virology. 25:41-45

The development of new therapeutic agents against hepatitis B virus (HBV) and the predictable emergence of resistant mutants have highlighted the need to provide new molecular assays for optimal therapeutic management. Similarly, other variants and g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dcc10fa656153f7971e632d8c08dd0
https://doi.org/10.1016/s1386-6532(02)00193-2

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