Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

Autor: Jennifer P. Newman, Grace Y. Wang, Kazuhiko Arima, Shou P. Guan, Michael R. Waters, Webster K. Cavenee, Edward Pan, Edita Aliwarga, Siao T. Chong, Catherine Y. L. Kok, Berwini B. Endaya, Amyn A. Habib, Tomohisa Horibe, Wai H. Ng, Ivy A. W. Ho, Kam M. Hui, Tomasz Kordula, Paula Y. P. Lam

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferati

Externí odkaz: https://doaj.org/article/86a25a0c882247c39b38bbcac00ca539

Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trial.

Autor: Bielcikova Z; Department of Oncology, First Faculty of Medicine, Charles University, and General University Hospital, Prague 128 08, Czech Republic., Stursa J; Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic., Krizova L; Department of Oncology, First Faculty of Medicine, Charles University, and General University Hospital, Prague 128 08, Czech Republic., Dong L; School of Pharmacy and Medical Science, Griffith University, Southport, Qld 4222, Australia., Spacek J; Department of Oncology, First Faculty of Medicine, Charles University, and General University Hospital, Prague 128 08, Czech Republic., Hlousek S; Department of Oncology, First Faculty of Medicine, Charles University, and General University Hospital, Prague 128 08, Czech Republic., Vocka M; Department of Oncology, First Faculty of Medicine, Charles University, and General University Hospital, Prague 128 08, Czech Republic., Rohlenova K; Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic., Bartosova O; Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague 128 08, Czech Republic., Cerny V; Department of Radiodiagnostics, First Faculty of Medicine, Charles University, and General University Hospital, Prague 128 08, Czech Republic., Padrta T; Department of Radiodiagnostics, First Faculty of Medicine, Charles University, and General University Hospital, Prague 128 08, Czech Republic., Pesta M; Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University, Prague 121 06, Czech Republic., Michalek P; Department of Anesthesiology and Intensive Care, First Faculty of Medicine, Charles University and General University Hospital, Prague 128 08, Czech Republic., Hubackova SS; Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic.; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4 140 21, Czech Republic., Kolostova K; Laboratory of Personalized Medicine, Oncology Clinic, Faculty Hospital Kralovske Vinohrady, Prague 10 100 34, Czech Republic., Pospisilova E; Laboratory of Personalized Medicine, Oncology Clinic, Faculty Hospital Kralovske Vinohrady, Prague 10 100 34, Czech Republic., Bobek V; Laboratory of Personalized Medicine, Oncology Clinic, Faculty Hospital Kralovske Vinohrady, Prague 10 100 34, Czech Republic., Klezl P; Laboratory of Personalized Medicine, Oncology Clinic, Faculty Hospital Kralovske Vinohrady, Prague 10 100 34, Czech Republic.; Urology Clinic, Third Faculty of Medicine, Charles University and Faculty Hospital Kralovske Vinohrady, Prague 10 100 34, Czech Republic., Zobalova R; Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic., Endaya B; Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic.; Department of Pediatrics and Inherited Metabolic Diseases, First Faculty of Medicine, Charles University, Prague 2 128 08, Czech Republic., Rohlena J; Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic., Petruzelka L; Department of Oncology, First Faculty of Medicine, Charles University, and General University Hospital, Prague 128 08, Czech Republic., Werner L; Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic., Neuzil J; Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic.; School of Pharmacy and Medical Science, Griffith University, Southport, Qld 4222, Australia.; Department of Pediatrics and Inherited Metabolic Diseases, First Faculty of Medicine, Charles University, Prague 2 128 08, Czech Republic.; Department of Physiology, Faculty of Science, Charles University, Prague 2 128 00, Czech Republic.

Publikováno v: EClinicalMedicine [EClinicalMedicine] 2023 Feb 23; Vol. 57, pp. 101873. Date of Electronic Publication: 2023 Feb 23 (Print Publication: 2023).

Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice.

Autor: Vacurova E; Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic.; Faculty of Science, Charles University, Prague, Czech Republic., Trnovska J; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic., Svoboda P; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague, Czech Republic., Skop V; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, 20892, USA., Novosadova V; Institute of Molecular Genetics, Czech Academy of Sciences, Prague-West, Czech Republic., Reguera DP; Institute of Molecular Genetics, Czech Academy of Sciences, Prague-West, Czech Republic., Petrezselyová S; Institute of Molecular Genetics, Czech Academy of Sciences, Prague-West, Czech Republic., Piavaux B; Institute of Molecular Genetics, Czech Academy of Sciences, Prague-West, Czech Republic., Endaya B; Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic., Spoutil F; Institute of Molecular Genetics, Czech Academy of Sciences, Prague-West, Czech Republic., Zudova D; Institute of Molecular Genetics, Czech Academy of Sciences, Prague-West, Czech Republic., Stursa J; Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic., Melcova M; Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague, Czech Republic., Bielcikova Z; General University Hospital, Prague, Czech Republic., Werner L; Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic., Prochazka J; Institute of Molecular Genetics, Czech Academy of Sciences, Prague-West, Czech Republic., Sedlacek R; Institute of Molecular Genetics, Czech Academy of Sciences, Prague-West, Czech Republic., Huttl M; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic., Hubackova SS; Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic. sona.stemberkova@ibt.cas.cz., Haluzik M; Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. halm@ikem.cz., Neuzil J; Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic. j.neuzil@griffith.edu.au.; School of Pharmacy and Medical Science, Griffith University, Southport, QLD, Australia. j.neuzil@griffith.edu.au.

Publikováno v: Nature communications [Nat Commun] 2022 Apr 06; Vol. 13 (1), pp. 1866. Date of Electronic Publication: 2022 Apr 06.

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Autor: Bajzikova M; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic., Kovarova J; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic. Electronic address: jaromira.kovarova@ibt.cas.cz., Coelho AR; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal., Boukalova S; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Oh S; College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul 08826, Korea., Rohlenova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Svec D; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Hubackova S; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Endaya B; School of Medical Science, Griffith University, Southport, QLD 4222, Australia., Judasova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Bezawork-Geleta A; School of Medical Science, Griffith University, Southport, QLD 4222, Australia., Kluckova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Chatre L; Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France; CNRS UMR 3738, Team Stability of Nuclear and Mitochondrial DNA, 75015 Paris, France., Zobalova R; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Novakova A; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Vanova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Ezrova Z; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic., Maghzal GJ; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, UNSW Medicine, University of New South Wales, Sydney, NSW 2052, Australia., Magalhaes Novais S; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic., Olsinova M; Faculty of Science, Charles University, 128 44 Prague, Czech Republic., Krobova L; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., An YJ; College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul 08826, Korea., Davidova E; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic., Nahacka Z; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Sobol M; Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic., Cunha-Oliveira T; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal., Sandoval-Acuña C; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Strnad H; Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic., Zhang T; Institute for Glycomics, Griffith University, Southport, 4222 QLD, Australia., Huynh T; Eunice Kennedy Shriver Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Serafim TL; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal., Hozak P; Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic., Sardao VA; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal., Koopman WJH; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6525 Nijmegen, the Netherlands., Ricchetti M; Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France; CNRS UMR 3738, Team Stability of Nuclear and Mitochondrial DNA, 75015 Paris, France., Oliveira PJ; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal., Kolar F; Institute of Physiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic., Kubista M; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Truksa J; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic., Dvorakova-Hortova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic., Pacak K; Eunice Kennedy Shriver Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Gurlich R; Third Faculty Hospital, Charles University, Prague, Czech Republic., Stocker R; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, UNSW Medicine, University of New South Wales, Sydney, NSW 2052, Australia., Zhou Y; Institute for Glycomics, Griffith University, Southport, 4222 QLD, Australia., Berridge MV; Malaghan Institute of Medical Research, Wellington 6242, New Zealand., Park S; College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul 08826, Korea. Electronic address: psh@snu.ac.kr., Dong L; School of Medical Science, Griffith University, Southport, QLD 4222, Australia. Electronic address: l.dong@griffith.edu.au., Rohlena J; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic. Electronic address: rohlenaj@ibt.cas.cz., Neuzil J; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; School of Medical Science, Griffith University, Southport, QLD 4222, Australia. Electronic address: j.neuzil@griffith.edu.au.

Publikováno v: Cell metabolism [Cell Metab] 2019 Feb 05; Vol. 29 (2), pp. 399-416.e10. Date of Electronic Publication: 2018 Nov 15.

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells.

Autor: Dong LF; School of Medical Science, Griffith University, Southport, Australia., Kovarova J; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Bajzikova M; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Bezawork-Geleta A; School of Medical Science, Griffith University, Southport, Australia., Svec D; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Endaya B; School of Medical Science, Griffith University, Southport, Australia., Sachaphibulkij K; School of Medical Science, Griffith University, Southport, Australia., Coelho AR; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic.; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Cantanhede, Portugal., Sebkova N; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic.; Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic., Ruzickova A; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Tan AS; Malaghan Institute of Medical Research, Wellington, New Zealand., Kluckova K; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Judasova K; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Zamecnikova K; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic.; Zittau/Goerlitz University of Applied Sciences, Zittau, Germany., Rychtarcikova Z; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic., Gopalan V; School of Medical Science, Griffith University, Southport, Australia.; School of Medicine, Griffith University, Southport, Australia., Andera L; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Sobol M; Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic., Yan B; School of Medical Science, Griffith University, Southport, Australia., Pattnaik B; CSIR Institute of Genomics and Integrative Biology, New Delhi, India., Bhatraju N; CSIR Institute of Genomics and Integrative Biology, New Delhi, India., Truksa J; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Stopka P; Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic., Hozak P; Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic., Lam AK; School of Medicine, Griffith University, Southport, Australia., Sedlacek R; Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic., Oliveira PJ; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Cantanhede, Portugal., Kubista M; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic.; TATAA Biocenter, Gothenburg, Sweden., Agrawal A; CSIR Institute of Genomics and Integrative Biology, New Delhi, India., Dvorakova-Hortova K; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic.; Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic., Rohlena J; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic., Berridge MV; Malaghan Institute of Medical Research, Wellington, New Zealand., Neuzil J; School of Medical Science, Griffith University, Southport, Australia.; Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic.

Publikováno v: ELife [Elife] 2017 Feb 15; Vol. 6. Date of Electronic Publication: 2017 Feb 15.