Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Berwini, Endaya"'
Autor:
Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101873- (2023)
Summary: Background: Mitochondria present an emerging target for cancer treatment. We have investigated the effect of mitochondrially targeted tamoxifen (MitoTam), a first-in-class anti-cancer agent, in patients with solid metastatic tumours. Methods
Externí odkaz:
https://doaj.org/article/91ab15755d5b4f4c9326f015bc30ba5c
Autor:
Eliska Vacurova, Jaroslava Trnovska, Petr Svoboda, Vojtech Skop, Vendula Novosadova, David Pajuelo Reguera, Silvia Petrezselyová, Benoit Piavaux, Berwini Endaya, Frantisek Spoutil, Dagmar Zudova, Jan Stursa, Magdalena Melcova, Zuzana Bielcikova, Lukas Werner, Jan Prochazka, Radislav Sedlacek, Martina Huttl, Sona Stemberkova Hubackova, Martin Haluzik, Jiri Neuzil
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Senescent cells play a role in pathogenesis of diabetes, and senolytic agents can improve obesity- and diabetes-related pathologies. Here the authors report that mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activit
Externí odkaz:
https://doaj.org/article/e1a97d3a7b444e588a78bce984149ca2
Autor:
Sona Stemberkova‐Hubackova, Renata Zobalova, Maria Dubisova, Jana Smigova, Sarka Dvorakova, Klara Korinkova, Zuzana Ezrova, Berwini Endaya, Kristyna Blazkova, Erik Vlcak, Petra Brisudova, Dan‐Diem Thi Le, Stefan Juhas, Daniel Rosel, Cristina Daniela Kelemen, Dana Sovilj, Eliska Vacurova, Tomas Cajka, Vlada Filimonenko, Lanfeng Dong, Ladislav Andera, Pavel Hozak, Jan Brabek, Zuzana Bielcikova, Jan Stursa, Lukas Werner, Jiri Neuzil
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 3, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/6ffa7e718404400f926a4f1d5c918cd7
Autor:
Sehyun Oh, Sihyang Jo, Han Sun Kim, Van-Hieu Mai, Berwini Endaya, Jiri Neuzil, Kyung Hee Jung, Soon-Sun Hong, Jin-Mo Kim, Sunghyouk Park
Publikováno v:
Analytical Chemistry.
Early diagnosis of hepatocellular carcinoma (HCC) is difficult; the lack of convenient biomarker-based diagnostic modalities renders high-risk HCC patients burdened by life-long periodical examinations. Here, a new chemical biopsy approach was develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7eca071d8ade42d2ae11a0e948b616
https://doi.org/10.1021/acs.analchem.2c03944
https://doi.org/10.1021/acs.analchem.2c03944
Autor:
Lan-Feng Dong, Jaromira Kovarova, Martina Bajzikova, Ayenachew Bezawork-Geleta, David Svec, Berwini Endaya, Karishma Sachaphibulkij, Ana R Coelho, Natasa Sebkova, Anna Ruzickova, An S Tan, Katarina Kluckova, Kristyna Judasova, Katerina Zamecnikova, Zuzana Rychtarcikova, Vinod Gopalan, Ladislav Andera, Margarita Sobol, Bing Yan, Bijay Pattnaik, Naveen Bhatraju, Jaroslav Truksa, Pavel Stopka, Pavel Hozak, Alfred K Lam, Radislav Sedlacek, Paulo J Oliveira, Mikael Kubista, Anurag Agrawal, Katerina Dvorakova-Hortova, Jakub Rohlena, Michael V Berridge, Jiri Neuzil
Publikováno v:
eLife, Vol 6 (2017)
Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ0 cells) is linked to the acquisition of the host mtDNA. However, the mechanism of mtDNA movement between cells remains unresolved. To deter
Externí odkaz:
https://doaj.org/article/4285105d6a3d4ae5a57e35604fc4c03d
Autor:
Eliska Vacurova, Jaroslava Trnovska, Petr Svoboda, Vojtech Skop, Vendula Novosadova, David Pajuelo Reguera, Silvia Petrezselyová, Benoit Piavaux, Berwini Endaya, Frantisek Spoutil, Dagmar Zudova, Jan Stursa, Magdalena Melcova, Zuzana Bielcikova, Lukas Werner, Jan Prochazka, Radislav Sedlacek, Martina Huttl, Sona Stemberkova Hubackova, Martin Haluzik, Jiri Neuzil
Publikováno v:
Nature communications. 13(1)
Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fc39d0b93e345792637ba4b42f6e47
https://pubmed.ncbi.nlm.nih.gov/35387987
https://pubmed.ncbi.nlm.nih.gov/35387987
Autor:
Ivy A.W. Ho, Berwini Endaya, Catherine Y. L. Kok, Siao T. Chong, Paula Y.P. Lam, Kazuhiko Arima, Jennifer P. Newman, Kam M. Hui, Michael R. Waters, Edita Aliwarga, Edward Pan, Webster K. Cavenee, Tomohisa Horibe, Amyn A. Habib, Tomasz Kordula, Shou P. Guan, Grace Y. Wang, Wai Hoe Ng
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications
The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is undetectable in normal brain which makes it a highly suitable target for diagnostic and therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5f22e40e95136394f76a30a46c06eb
https://doaj.org/article/86a25a0c882247c39b38bbcac00ca539
https://doaj.org/article/86a25a0c882247c39b38bbcac00ca539
Autor:
Shou P. Guan, Kam M. Hui, Kian Chuan Sia, Siao T. Chong, Alexander Y. F. Chung, Berwini Endaya, Catherine Y. L. Kok, Jennifer P. Newman, Bin B. Liu, Paula Y.P. Lam, Hung Huynh
Publikováno v:
Oncotarget
The epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein that is regarded as one of the markers for tumor initiating cells (TIC) in human hepatocellular carcinoma (HCC). Much work has been directed towards targeting these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae407f00f1a162ce83855a78b51e42f
https://doi.org/10.18632/oncotarget.17633
https://doi.org/10.18632/oncotarget.17633
Autor:
Berwini Endaya, Jiri Neuzil, Jiri Cerny, Renata Zobalova, Pavel Hozák, Bing Yan, Tomáš Špaček, Petr Jezek, Karishma Sachaphibulkij, Jakub Rohlena, Jan Blecha, Katerina Rohlenova, Lan-Feng Dong, Margaryta Sobol, Lukas Werner, Jacob Goodwin, Magdalena Vondrusova, Elham Alizadeh Pesdar, Maria Nga Nguyen, Jan Stursa, Ayenachew Bezawork-Geleta, Jaroslav Truksa
Publikováno v:
Antioxidants & Redox Signaling. 26:84-103
Aims: Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether disruption of the electron transport chain (ETC) is a viable strategy to elimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e2daaac3c4cca08da325ce09bf1eba
https://doi.org/10.1089/ars.2016.6677
https://doi.org/10.1089/ars.2016.6677
Autor:
Jin-Ming A. Ng, Tom Walker, Faisal Alowaidi, Alan Mackay-Sim, Berwini Endaya, Nicholas de Pennington, Jiri Neuzil, Paula Y.P. Lam, Adrian Cuda Banda Meedeniya, Brenton Cavanagh
Publikováno v:
Journal of Neuroscience Methods. 257:121-133
Background The characterisation of dividing brain cells is fundamental for studies ranging from developmental and stem cell biology, to brain cancers. Whilst there is extensive anatomical data on these dividing cells, limited gene transcription data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252e79df011530ee3028990e8674330b
https://doi.org/10.1016/j.jneumeth.2015.09.020
https://doi.org/10.1016/j.jneumeth.2015.09.020