Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice.

Autor: Ke YD; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. Electronic address: yazi.ke@mq.edu.au., van Hummel A; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Au C; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Chan G; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Lee WS; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., van der Hoven J; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Przybyla M; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Deng Y; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Sabale M; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Morey N; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Bertz J; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Feiten A; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Ippati S; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Stevens CH; School of Chemistry and Molecular Bioscience, University of Wollongong and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia., Yang S; Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Gladbach A; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Haass NK; The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia., Kril JJ; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2050, Australia., Blair IP; Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Delerue F; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia., Ittner LM; Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. Electronic address: lars.ittner@mq.edu.au.

Publikováno v: Neuron [Neuron] 2024 Apr 17; Vol. 112 (8), pp. 1249-1264.e8. Date of Electronic Publication: 2024 Feb 15.

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PLP1-Targeting Antisense Oligonucleotides Improve FOXG1 Syndrome Mice.

Autor: Tan, Daniel C. S.¹ (AUTHOR) tancsdaniel@gmail.com, Jung, Seonghee¹ (AUTHOR) seonghee.jung@mq.edu.au, Deng, Yuanyuan¹ (AUTHOR) yuanyuan.deng@mq.edu.au, Morey, Nicolle¹ (AUTHOR) nicollemorey@gmail.com, Chan, Gabriella¹ (AUTHOR) gabriella.chan1@outlook.com, Bongers, Andre² (AUTHOR) andre.bongers@unsw.edu.au, Ke, Yazi D.¹ (AUTHOR) yazi.ke@mq.edu.au, Ittner, Lars M.¹ (AUTHOR), Delerue, Fabien¹ (AUTHOR) fdelerue@mdanderson.org

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10846. 21p.

Dual PPARα/γ Ligand TZD18 Either Alone or in Combination with Imatinib Inhibits Proliferation and Induces Apoptosis of Human CML Cell Lines

Autor: Chuanbing Zang, Hongyu Liu, E. Elstner, Jan Eucker, Bertz J, Possinger K, Koeffler Hp, Waechter M

Publikováno v: Cell Cycle. 5:2237-2243

Despite progress in the treatment of early-stage chronic myeloid leukemia (CML), the accelerated and blastic phases of CML still remain a therapeutic challenge. Persistence of BCR-ABL-positive (bcr-abl(+)) cells or secondary resistance during imatini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d019f619524fa5aee68eff137bb9aa2
https://doi.org/10.4161/cc.5.19.3259