Sensory perception in model and pathogenic fungi : engineering misappropriation of response

Autor: Bertuzzi, Margherita

The research described characterises pH signalling in the human pathogen Aspergillus fumigatus. Normal functioning of this regulatory system in Aspergillus species requires the integrity of seven genes, including the DNA binding transcription factor

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533559

TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation.

Autor: Worboys, Jonathan D., Vowell, Katherine N., Hare, Roseanna K., Ambrose, Ashley R., Bertuzzi, Margherita, Conner, Michael A., Patel, Florence P., Zammit, William H., Gali-Moya, Judit, Hazime, Khodor S., Jones, Katherine L., Rey, Camille, Jonjic, Stipan, Rovis, Tihana Lenac, Tannahill, Gillian M., Cruz De Matos, Gabriela Dos Santos, Waight, Jeremy D., Davis, Daniel M.

Publikováno v: Nature Communications; 8/18/2023, Vol. 14 Issue 1, p1-21, 21p

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The mechanistic basis of pH-dependent 5-flucytosine resistance in Aspergillus fumigatus

Autor: Gsaller, Fabio, Furukawa, Takanori, Carr, Paul D., Rash, Bharatkumar, Jöchl, Christoph, Bertuzzi, Margherita, Bignell, Elaine, Bromley, Michael

Publikováno v: Gsaller, F, Furukawa, T, Carr, P D, Rash, B, Jöchl, C, Bertuzzi, M, Bignell, E & Bromley, M 2018, ' The mechanistic basis of pH-dependent 5-flucytosine resistance in Aspergillus fumigatus ', Antimicrobial Agents and Chemotherapy, vol. 62, no. 6, pp. e02593-17 . https://doi.org/10.1128/AAC.02593-17, https://doi.org/10.1128/aac.02593-17

The antifungal drug 5-flucytosine (5FC), a derivative of the nucleobase cytosine, is licensed for the treatment of fungal diseases; however, it is rarely used as a monotherapeutic to treat Aspergillus infection. Despite being potent against other fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::32bdc5b676b967635ecad0e42f3eed15
https://doi.org/10.1128/AAC.02593-17

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