Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study.

Autor: Douville NJ; Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan.; Institute of Healthcare Policy & Innovation, University of Michigan, Ann Arbor, Michigan.; Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan., Bastarache L; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., He J; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Wu KH; Regeneron Pharmaceuticals, Tarrytown, New York., Vanderwerff B; Precision Health, University of Michigan, Ann Arbor, MI., Bertucci-Richter E; Precision Health, University of Michigan, Ann Arbor, MI., Hornsby WE; The Broad Institute, Cambridge, Massachusetts., Lewis A; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Jewell ES; Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan., Kheterpal S; Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan., Shah N; Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan., Mathis M; Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan.; Institute of Healthcare Policy & Innovation, University of Michigan, Ann Arbor, Michigan.; Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan., Engoren MC; Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan., Douville CB; Department of Oncology, The Johns Hopkins School of Medicine, Baltimore, Maryland., Surakka I; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor., Willer C; Regeneron Pharmaceuticals, Tarrytown, New York., Kertai MD; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.

Publikováno v: Anesthesiology [Anesthesiology] 2024 Sep 09. Date of Electronic Publication: 2024 Sep 09.

Aging clocks based on accumulating stochastic variation.

Autor: Meyer DH; Institute for Genome Stability in Aging and Disease, University Hospital and University of Cologne, Cologne, Germany. david.meyer@uni-koeln.de.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. david.meyer@uni-koeln.de., Schumacher B; Institute for Genome Stability in Aging and Disease, University Hospital and University of Cologne, Cologne, Germany. bjoern.schumacher@uni-koeln.de.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. bjoern.schumacher@uni-koeln.de.

Publikováno v: Nature aging [Nat Aging] 2024 Jun; Vol. 4 (6), pp. 871-885. Date of Electronic Publication: 2024 May 09.

The Information Theory of Aging.

Autor: Lu YR; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Tian X; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Sinclair DA; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. david_sinclair@hms.harvard.edu.

Publikováno v: Nature aging [Nat Aging] 2023 Dec; Vol. 3 (12), pp. 1486-1499. Date of Electronic Publication: 2023 Dec 15.