Human cardiac fibroblasts expressing VCAM1 improve heart function in postinfarct heart failure rat models by stimulating lymphangiogenesis.

Autor: Takahiro Iwamiya, Bertrand-David Segard, Yuimi Matsuoka, Tomomi Imamura

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0237810 (2020)

Cardiovascular diseases are a leading cause of death worldwide. After an ischemic injury, the myocardium undergoes severe necrosis and apoptosis, leading to a dramatic degradation of function. Numerous studies have reported that cardiac fibroblasts (

Externí odkaz: https://doaj.org/article/85b7f9cb32de4ee0bdedcc99e6afbe0a

A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte-like cells

Autor: Yannick Tauran, Myriam Lereau‐Bernier, Bertrand David Segard, Mathieu Danoy, Keiichi Kimura, Marie Shinohara, Arnaud Brioude, Yasuyuki Sakai, Hugo de Jonge, Oleg Melnyk, Jérôme Vicogne, Eric Leclerc

Publikováno v: Development, growthdifferentiationREFERENCES. 64(9)

Hepatocyte growth factor (HGF) is the natural ligand of the MET receptor tyrosine kinase. This ligand-receptor couple is essential for the maturation process of hepatocytes. Previously, the rational design of a synthetic protein based on the assembly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d77fcc42c0053f98cbeabce2dbc69b4
https://pubmed.ncbi.nlm.nih.gov/36251346

Quantification of tube topography on micrographs of fluorescent staining of multi-layers cell culture. v1

Autor: Bertrand-David Segard

The induction or inhibition of angiogenesis can be assessed in vitro by the differentiation of endothelial cells. Indeed, these cells are capable of forming structures resembling a capillary network in culture. This approach is known as Endothelial T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8218182587c84a00b42fe6837bad817d
https://doi.org/10.17504/protocols.io.bhtaj6ie

Integration of metabolomic and transcriptomic profiling to compare two protocols of differentiation of human induced pluripotent stem cells into hepatocytes

Autor: Stéphane Poulain, Yasuyuki Sakai, Charles Plessy, Eric Leclerc, Françoise Gilard, Sachi Kato, Myriam Lereau Bernier, Taketomo Kido, Yannick Tauran, Mathieu Danoy, Bertrand-David Segard, Atsushi Miyajima, Rachid Jellali

Publikováno v: Process Biochemistry
Process Biochemistry, 2019, 88, pp.139-147. ⟨10.1016/j.procbio.2019.09.034⟩
Process Biochemistry, Elsevier, 2019, 88, pp.139-147. ⟨10.1016/j.procbio.2019.09.034⟩

International audience; Human hepatocyte-like cells derived from human induced pluripotent stem cells (hiPSC) may provide an unlimited supply of cells for in vitro liver models. However, hiPSC differentiation remains a major challenge due to immaturi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22df9446d53ca7a08daaaa795cb692ef
https://hal.science/hal-02357452

Alterations of redox dynamics and desmin post-translational modifications in skeletal muscle models of desminopathies

Autor: Meng-Er Huang, Guilhem Clary, Sabrina Batonnet-Pichon, Florence Delort, Fany Bourgois-Rocha, Eva Cabet, Onnik Agbulut, Alain Lilienbaum, Coralie Hakibilen, Patrick Vicart, Bertrand-David Segard

Publikováno v: Experimental Cell Research
Experimental Cell Research, Elsevier, 2019, 383 (2), pp.111539. ⟨10.1016/j.yexcr.2019.111539⟩

International audience; Desminopathies are a type of myofibrillar myopathy resulting from mutations in DES, encoding the intermediate filament protein desmin. They display heterogeneous phenotypes, suggesting environment influences. Patient muscle pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d36c413405a3476fe717337b0b1a02
https://pubmed.ncbi.nlm.nih.gov/31369751