Výsledky vyhledávání - "Bertrand Rochat"

Akademický článek

LC-HRMS Metabolomics for Untargeted Diagnostic Screening in Clinical Laboratories: A Feasibility Study

Autor: Bertrand Rochat, Rayane Mohamed, Pierre-Edouard Sottas

Publikováno v: Metabolites, Vol 8, Iss 2, p 39 (2018)

Today’s high-resolution mass spectrometers (HRMS) allow bioanalysts to perform untargeted/global determinations that can reveal unexpected compounds or concentrations in a patient’s sample. This could be performed for preliminary diagnosis attemp

Externí odkaz: https://doaj.org/article/077db587b29741e1a94ec369cc3c11b4

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Akademický článek

A Close Look at the Fate of Compounds we are Exposed to

Autor: Bertrand Rochat, Baptiste Grund, Julia Bilat

Publikováno v: CHIMIA, Vol 68, Iss 11 (2014)

Externí odkaz: https://doaj.org/article/f9a5d4286f8845ee8f4590bdcbc6ddd3

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Akademický článek

Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.

Autor: Céline Narjoz, Amélie Favre, Justin McMullen, Philippe Kiehl, Michael Montemurro, William D Figg, Philippe Beaune, Isabelle de Waziers, Bertrand Rochat

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e95532 (2014)

We have investigated in vitro the metabolic capability of 3 extrahepatic cytochromes P-450, CYP1A1, 1B1 and 2J2, known to be over-expressed in various tumors, to biotransform 5 tyrosine kinase inhibitors (TKI): dasatinib, imatinib, nilotinib, sorafen

Externí odkaz: https://doaj.org/article/d21312ddee844f25aa3d81c27af1a523

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Validation and clinical application of a multiplex high performance liquid chromatography - tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections

Autor: Sabine Laila Lahrichi, Raphaël Burger, Jean-Luc Pagani, O. Marchetti, Nicole Guignard, Thomas Mercier, Nicolas Widmer, Chantal Csajka, Philippe Eggimann, Pascal André, Bertrand Rochat, Eva Choong, Benoît Pesse, Frédéric Lamoth, Sandra Cruchon, Laurent A. Decosterd, Thierry Buclin, Beatrice Ternon

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 1157, pp. 122160
Journal of Chromatography. B (2020) P. 122160

Objective Unpredictable pharmacokinetics of antibiotics in patients with life-threatening bacterial infections is associated with drug under- or overdosing. Therapeutic drug monitoring (TDM) may guide dosing adjustment aimed at maximizing antibacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf4c34c5310c3ad5cf39f2fa70091f0
https://serval.unil.ch/resource/serval:BIB_2ABB9B287690.P001/REF.pdf

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Robust and sensitive peptidomics workflow for plasma based on specific extraction, lipid removal, capillary LC setup and multinozzle ESI emitter

Autor: Bertrand Rochat, Patrice Waridel, Pierre-Edouard Sottas, Jachen Barblan, Manfredo Quadroni

Publikováno v: Talanta. 223(Pt 1)

We present a new workflow for the LC-MS determination of native peptides in plasma at picomolar levels. Collected whole blood was quickly diluted with an ice-cold solution in order to stop protease activity. Diluted plasma samples were extracted by p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327a82b90928cae308d7d3eb2a1f3895
https://pubmed.ncbi.nlm.nih.gov/33303132

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Quantitative and Qualitative LC-High-Resolution MS: The Technological and Biological Reasons for a Shift of Paradigm

Autor: Bertrand Rochat

Publikováno v: Recent Advances in Analytical Chemistry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a33cd486447c4cc3be9b8a53bf76524
http://www.intechopen.com/articles/show/title/quantitative-and-qualitative-lc-high-resolution-ms-the-technological-and-biological-reasons-for-a-sh

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From targeted quantification to untargeted metabolomics: Why LC-high-resolution-MS will become a key instrument in clinical labs

Autor: Bertrand Rochat

Publikováno v: TrAC Trends in Analytical Chemistry. 84:151-164

Most late model high-resolution mass spectrometers (HRMS) are capable of performing sensitive and reliable quantifications of a large variety of analytes in global HR-full scan (HR-FS) or, if needed, in a more targeted SIM or MS2 mode. Usual LC-HRMS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c02bb1ed709851afa1e534f23604988b
https://doi.org/10.1016/j.trac.2016.02.009

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Fully-automated systems and the need for global approaches should exhort clinical labs to reinvent routine MS analysis?

Autor: Bertrand Rochat

Publikováno v: Bioanalysis. 10(14)

Today, many LC–high-resolution MS instruments have become affordable, easy-to-use, sensitive and quantitative. Meanwhile, there is an increased need for more comprehensive approaches. However, omics analyses are still restricted to specialists wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0171b544c31791854df5d2fcc18aed
https://pubmed.ncbi.nlm.nih.gov/29989424

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LC-HRMS Metabolomics for Untargeted Diagnostic Screening in Clinical Laboratories: A Feasibility Study

Autor: Pierre-Edouard Sottas, Rayane Mohamed, Bertrand Rochat

Publikováno v: Metabolites
Volume 8
Issue 2
Metabolites, Vol 8, Iss 2, p 39 (2018)

Today&rsquo
s high-resolution mass spectrometers (HRMS) allow bioanalysts to perform untargeted/global determinations that can reveal unexpected compounds or concentrations in a patient&rsquo
s sample. This could be performed for preliminar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1719960438059bbdfff21d3de357c444

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