Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Bertrand Dulery"'
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 725:39-47
The growing interest in combinatorial chemistry has led to a new source of compounds from which a large number of leads has emerged over recent years. Parallel synthesis, in particular, allows a quick production of a wide number of individual compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612c33fa153296a90b2a432afa62f1da
https://doi.org/10.1016/s0378-4347(98)00570-2
https://doi.org/10.1016/s0378-4347(98)00570-2
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 672:207-215
An isocratic reversed-phase high-performance liquid chromatographic (HPLC) method using an Ultrasphere IP column has been developed for the determination of testosterone and its metabolites after incubation of 4- 14 C-labelled or unlabelled testoster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790127bb8e19618b51018175859ed385
https://doi.org/10.1016/0378-4347(95)00216-6
https://doi.org/10.1016/0378-4347(95)00216-6
Publikováno v:
Xenobiotica. 25:59-70
1. Piroximone was administered orally (p.o.) and intravenously (i.v.) to male Beagle dog. In vitro, piroximone was incubated with dog liver microsomes. 2. Piroximone was metabolized in vivo to five metabolites (1-5) representing approximately 20% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67365567cb86728ffd2bc3a296fd8b8
https://doi.org/10.3109/00498259509061833
https://doi.org/10.3109/00498259509061833
Autor:
Joelle Verne, Charlotte Gourmel, Bertrand Dulery, Jean-Luc Veuthey, Emilie Reginato, Julie Schappler, Laura Waller, Serge Rudaz, Davy Guillarme, Alexandre Grand-Guillaume Perrenoud
Publikováno v:
Journal of Chromatography. A, Vol. 1282 (2013) pp. 172-177
The aim of the present work was to compare various separation techniques for the fast analysis of closelyrelated compounds, including structurally-related compounds, positional isomers, diastereoisomers, Z/E isomers. Three analytical techniques were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9789f61a9234bffa5e543b0f2c97b0fc
https://pubmed.ncbi.nlm.nih.gov/23415443
https://pubmed.ncbi.nlm.nih.gov/23415443
Publikováno v:
Biological Mass Spectrometry. 22:377-382
A highly sensitive and specific assay has been developed for the determination of MDL 73745 [2,2,2-trifluoro-1-(3-trimethylsilyl-phenyl) ethanone] (I) and the internal standard (MDL 74398) at the nanomolar level in dog plasma and urine by gas chromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79ea0944b700afca79a873410e4d469
https://doi.org/10.1002/bms.1200220703
https://doi.org/10.1002/bms.1200220703
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 571:241-249
A sensitive and specific assay has been developed for the quantitative measurement in human plasma and urine of the irreversible inhibitor of monoamine oxidase B [(E)-4-fluoro-beta-fluoromethylenebenzene-butanamine HCl salt] (MDL 72974A) (I). This as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341dc20e62d68a95c415dba40b0a025b
https://doi.org/10.1016/0378-4347(91)80451-h
https://doi.org/10.1016/0378-4347(91)80451-h
Autor:
Daniel Schirlin, Jean-Marie Hornsperger, J Dow, Jean-Georges Heydt, Bertrand Dulery, Jean-Noel Collard
Publikováno v:
Alzheimer Disease ISBN: 9781461581512
Acetylcholinesterase inhibitors (AChEI) as palliative agents in the treatment of Alzheimer’s disease (AD) have been most widely studied so far. Novel compounds with higher lipophilicity, better selectivity and longer duration of inhibition are more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fc76fcbd3020099f68f650fdce39a5
https://doi.org/10.1007/978-1-4615-8149-9_23
https://doi.org/10.1007/978-1-4615-8149-9_23
Publikováno v:
Biological mass spectrometry. 21(12)
(E)-beta-Fluoromethylene-m-tyrosine (FMMT, MDL 72394) represents a prodrug approach to site-selective, irreversible inhibition of monoamine oxidase. A sensitive and specific method for the quantification of FMMT and its active metabolite (MDL 72392)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88e4b96fb9dca166408f9298dfe7896
https://pubmed.ncbi.nlm.nih.gov/1477108
https://pubmed.ncbi.nlm.nih.gov/1477108
Publikováno v:
Journal of chromatography. 593(1-2)
14C-labelled piroximone was administered to rats at a dose of 10 mg/kg body weight. Of the total radioactivity administered, 74.9 +/- 7.9% (n = 4) and 87.8 +/- 1.7 (n = 3) were recovered in the 8-h urine collection after oral and intravenous administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d289ac1315058a587e52b2547c15fc5a
https://pubmed.ncbi.nlm.nih.gov/1639892
https://pubmed.ncbi.nlm.nih.gov/1639892
The 5- and 6-fluoro derivatives of arachidonic acid (5F-ETE and 6F-ETE) were evaluated as substrates of rat basophilic leukaemia cell (RBL-1) 5-lipoxygenase. 5F-ETE was found to be a poor substrate and was converted into a single product, 5-oxoeicosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a996c3083240d09dc1a37f8135aed7d
https://europepmc.org/articles/PMC1151380/
https://europepmc.org/articles/PMC1151380/