Výsledky vyhledávání - "Bertrand Crozatier"

Akademický článek

EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

Publikováno v: eLife, Vol 12 (2023)

Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy and heart failure. Thi

Externí odkaz: https://doaj.org/article/cdffeb33bb6c47cd87e41bc7a93230d4

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EPAC1 inhibition prevents adverse cardiotoxicity induced by anticancer treatment

Autor: Frank Lezoualc'h, Christophe Lemaire, Marianne Mazevet, Bertrand Crozatier, Maisa de Souza Ribeiro, A. Belhadef, A.M. Gomez, Jean-Pierre Benitah, Eric Morel

Publikováno v: Archives of Cardiovascular Diseases Supplements. 12:243-244

Introduction Anticancer treatments (chemo- and radiation therapies), such as Doxorubicin (Dox), used to treat many types of cancer are associated with many side effects such as cardiotoxicity mainly leading to a dilated cardiomyopathy (DCM) in chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7656772e8c042c1e8ea4fa8dd11396c
https://doi.org/10.1016/j.acvdsp.2020.03.106

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P3116New role of EPAC1 in Anthracycline-induced cardiotoxicity and anticancer therapy

Autor: Christophe Lemaire, Bertrand Crozatier, Frank Lezoualc'h, M Ribeiro, Marianne Mazevet, A.M. Gomez, A Belhadef, M. Laudette, Jean-Pierre Benitah, Eric Morel

Publikováno v: European Heart Journal. 40

Introduction Doxorubicin (Dox) is an anthracycline commonly used to treat many types of cancer; unfortunately this chemotherapeutic agent induces many side effects such as cardiotoxicity leading to dilated cardiomyopathy (DCM). The cardiotoxicity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64502a35a8075416a99b5fca4dfc201b
https://doi.org/10.1093/eurheartj/ehz745.0191

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EPAC1 inhibition as a new therapeutic target in anthracyclines induced cardiotoxicity

Autor: Frank Lezoualc'h, A.M. Gomez, Bertrand Crozatier, Christophe Lemaire, Marianne Mazevet, M. Laudette, A. Belhadef, Eric Morel, Maisa de Souza Ribeiro, Jean-Pierre Benitah

Publikováno v: Archives of Cardiovascular Diseases Supplements. 13:216

Introduction Doxorubicin (Dox) is an Anthracycline commonly used to treat many types of cancer; unfortunately this chemotherapeutic agent often induces side effects such as cardiotoxicity leading to cardiomyocyte death and dilated cardiomyopathy (DCM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32d8594af290751d6937fd5e6c41d782
https://doi.org/10.1016/j.acvdsp.2021.04.167

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Shear Wave Imaging of Passive Diastolic Myocardial Stiffness

Autor: Bertrand Crozatier, Mathieu Couade, Wei-Ning Lee, Mathieu Pernot, Emmanuel Messas, Mickael Tanter, Philippe Mateo, Alain Bel

Publikováno v: JACC: Cardiovascular Imaging. 9:1023-1030

Objectives The aim of this study was to investigate the potential of shear wave imaging (SWI), a novel ultrasound-based technique, to noninvasively quantify passive diastolic myocardial stiffness in an ovine model of ischemic cardiomyopathy. Backgrou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cd6e8869ab503c85c3d6ba7aa0d27cc
https://doi.org/10.1016/j.jcmg.2016.01.022

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Progression of excitation-contraction coupling defects in doxorubicin cardiotoxicity

Autor: Maxance Ribeiro, Jean-Pierre Benitah, Audrey Ridoux, Rodolphe Fischmeister, Philippe Mateo, Ana Maria Gomez, Eric Morel, Marianne Mazevet, Anna Llach, Catherine Rucker-Martin, Olivier Villejouvert, Bertrand Crozatier

Publikováno v: Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, In press, ⟨10.1016/j.yjmcc.2018.11.019⟩
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

International audience; Cardiac failure is a common complication in cancer survivors treated with anthracyclines. Here we followed up cardiac function and excitation-contraction (EC) coupling in an in vivo doxorubicin (Dox) treated mice model (iv, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203712ee02a2ec3b930707a12e99cb3b
https://pubmed.ncbi.nlm.nih.gov/30500377

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Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway

Autor: Eric Morel, Bertrand Crozatier, Anne-Coline Laurent, Isabelle Hmitou, Mélanie Métrich, Nicolas Duquesnes, Magali Breckler, Delphine Courillau, Jean-Paul Blondeau, Frank Lezoualc'h

Publikováno v: Cellular Signalling. 22:1459-1468

Epac (Exchange protein directly activated by cAMP) is a sensor for cAMP and represents a novel mechanism for governing cAMP signalling. Epac is a guanine nucleotide exchange factor (GEF) for the Ras family of small GTPases, Rap. Previous studies demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8885540f71125868598b3293fd6e1d4
https://doi.org/10.1016/j.cellsig.2010.05.014

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Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology

Autor: Frank Lezoualc'h, Eric Morel, Ana María Gómez, Bertrand Crozatier, Magali Berthouze, Mélanie Métrich

Publikováno v: Pflügers Archiv - European Journal of Physiology. 459:535-546

Exchange proteins directly activated by cyclic AMP (Epac) were discovered 10 years ago as new sensors for the second messenger cyclic AMP (cAMP). Epac family, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcc294ead8a210ca7964958e541f50d
https://doi.org/10.1007/s00424-009-0747-y

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The EGF receptor activates ERK but not JNK Ras-dependently in basal conditions but ERK and JNK activation pathways are predominantly Ras-independent during cardiomyocyte stretch

Autor: Frank Lezoualc'h, Nicolas Duquesnes, Fanny Vincent, Eric Morel, Bertrand Crozatier

Publikováno v: The International Journal of Biochemistry & Cell Biology. 41:1173-1181

Myocardial stretch is a major determinant of ventricular hypertrophy, a physiological adaptational process that can be detrimental, leading to heart failure. Therapies aimed to limit the development of cardiac hypertrophy are thus currently evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb346f7b39b86b3e7b714dc9e7aa9e35
https://doi.org/10.1016/j.biocel.2008.09.032

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Shear Wave Imaging of Passive Diastolic Myocardial Stiffness: Stunned Versus Infarcted Myocardium

Autor: Mathieu, Pernot, Wei-Ning, Lee, Alain, Bel, Philippe, Mateo, Mathieu, Couade, Mickaël, Tanter, Bertrand, Crozatier, Emmanuel, Messas

Publikováno v: JACC. Cardiovascular imaging. 9(9)

The aim of this study was to investigate the potential of shear wave imaging (SWI), a novel ultrasound-based technique, to noninvasively quantify passive diastolic myocardial stiffness in an ovine model of ischemic cardiomyopathy.Evaluation of diasto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5aaf4ba07855b8db10dbd96eff2ddf14
https://pubmed.ncbi.nlm.nih.gov/27236519

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