Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bertrand C W, Tanner"'
Strain rate of stretch affects crossbridge detachment during relaxation of intact cardiac trabeculae
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/dfe6db154a3b4c26b5f97ca0d3da5fbf
Autor:
Peter O. Awinda, Weikang Ma, Kyrah L. Turner, Jing Zhao, Henry Gong, Mindy S. Thompson, Kenneth S. Campbell, Thomas C. Irving, Bertrand C. W. Tanner
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15084 (2022)
Myosin cross-bridges dissociate from actin following Mg2+-adenosine triphosphate (MgATP) binding. Myosin hydrolyses MgATP into inorganic phosphate (Pi) and Mg2+-adenosine diphosphate (ADP), and release of these hydrolysis products drives chemo-mechan
Externí odkaz:
https://doaj.org/article/4b3d2da720e0436f80c18278c270a1ce
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190335 (2017)
Muscles produce force and power by utilizing chemical energy through ATP hydrolysis. During concentric contractions (shortening), muscles generate less force compared to isometric contractions, but consume greater amounts of energy as shortening velo
Externí odkaz:
https://doaj.org/article/8e82d74178be40ca9d0d582ae7706038
Autor:
Peter O, Awinda, Marissa, Watanabe, Yemeserach, Bishaw, Anna M, Huckabee, Keinan B, Agonias, Katarzyna, Kazmierczak, Danuta, Szczesna-Cordary, Bertrand C W, Tanner
Publikováno v:
Am J Physiol Heart Circ Physiol
Morbidity and mortality associated with heart disease is a growing threat to the global population, and novel therapies are needed. Mavacamten (formerly called MYK-461) is a small molecule that binds to cardiac myosin and inhibits myosin ATPase. Mava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9556d1c34ff2f57d61885ae211b80d11
https://pubmed.ncbi.nlm.nih.gov/33337957
https://pubmed.ncbi.nlm.nih.gov/33337957
Autor:
Peter O, Awinda, Yemeserach, Bishaw, Marissa, Watanabe, Maya A, Guglin, Kenneth S, Campbell, Bertrand C W, Tanner
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Heart failure can reflect impaired contractile function at the myofilament level. In healthy hearts, myofilaments become more sensitive to Ca(2+) as cells are stretched. This represents a fundamental property of the myocardium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a89779c0ed48fcd7529d9b1bea3f0770
https://pubmed.ncbi.nlm.nih.gov/32960449
https://pubmed.ncbi.nlm.nih.gov/32960449
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 5, p e1002506 (2012)
Striated muscle contraction is a highly cooperative process initiated by Ca²⁺ binding to the troponin complex, which leads to tropomyosin movement and myosin cross-bridge (XB) formation along thin filaments. Experimental and computational studies
Externí odkaz:
https://doaj.org/article/85c933d2fc2c426fb2c66329017020c4
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 7, p e115 (2007)
In muscle, force emerges from myosin binding with actin (forming a cross-bridge). This actomyosin binding depends upon myofilament geometry, kinetics of thin-filament Ca(2+) activation, and kinetics of cross-bridge cycling. Binding occurs within a co
Externí odkaz:
https://doaj.org/article/06b24139830944f199fac203c36f119c