Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Bertrand Blondeau"'
1
Akademický článek
RevGel-seq: instrument-free single-cell RNA sequencing using a reversible hydrogel for cell-specific barcoding
Autor: Jun Komatsu, Alba Cico, Raya Poncin, Maël Le Bohec, Jörg Morf, Stanislav Lipin, Antoine Graindorge, Hélène Eckert, Azadeh Saffarian, Léa Cathaly, Frédéric Guérin, Sara Majello, Damien Ulveling, Anaïs Vayaboury, Nicolas Fernandez, Dilyana Dimitrova, Xavier Bussell, Yannick Fourne, Pierre Chaumat, Barbara André, Elodie Baldivia, Ulysse Godet, Mathieu Guinin, Vivien Moretto, Joy Ismail, Olivier Caille, Natacha Roblot, Carine Beaupère, Alexandrine Liboz, Ghislaine Guillemain, Bertrand Blondeau, Pierre Walrafen, Stuart Edelstein
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Progress in sample preparation for scRNA-seq is reported based on RevGel-seq, a reversible-hydrogel technology optimized for samples of fresh cells. Complexes of one cell paired with one barcoded bead are stabilized by a chemical linker and
Externí odkaz: https://doaj.org/article/a27fcb871ba44d87a05f139d18b0132e
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2
Akademický článek
Slug, a Cancer‐Related Transcription Factor, is Involved in Vascular Smooth Muscle Cell Transdifferentiation Induced by Platelet‐Derived Growth Factor‐BB During Atherosclerosis
Autor: Nahéma Ledard, Alexandrine Liboz, Bertrand Blondeau, Mégane Babiak, Célia Moulin, Benjamin Vallin, Isabelle Guillas, Véronique Mateo, Claire Jumeau, Karl Blirando, Olivier Meilhac, Isabelle Limon, Martine Glorian
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 2 (2020)
Background Heart attacks and stroke often result from occlusive thrombi following the rupture of vulnerable atherosclerotic plaques. Vascular smooth muscle cells (VSMCs) play a pivotal role in plaque vulnerability because of their switch towards a pr
Externí odkaz: https://doaj.org/article/99777b702bd5469289c5a7fb884d9e96
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3
Akademický článek
Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
Autor: Carine Beaupere, Alexandrine Liboz, Bruno Fève, Bertrand Blondeau, Ghislaine Guillemain
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2, p 623 (2021)
Glucocorticoids (GCs) are steroids secreted by the adrenal cortex under the hypothalamic-pituitary-adrenal axis control, one of the major neuro-endocrine systems of the organism. These hormones are involved in tissue repair, immune stability, and met
Externí odkaz: https://doaj.org/article/80de9fa1c19d4428b56f28bff88e27e7
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5
Akademický článek
Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells.
Autor: Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Riveline
Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149343 (2016)
Diabetes is a major complication of chronic Glucocorticoids (GCs) treatment. GCs induce insulin resistance and also inhibit insulin secretion from pancreatic beta cells. Yet, a full understanding of this negative regulation remains to be deciphered.
Externí odkaz: https://doaj.org/article/f254a129b34c4dbb89e321a1ef5d469e
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6
Akademický článek
Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation.
Autor: Jean-François Gautier, Raphaël Porcher, Charbel Abi Khalil, Naima Bellili-Munoz, Lila Sabrina Fetita, Florence Travert, Simeon-Pierre Choukem, Jean-Pierre Riveline, Samy Hadjadj, Etienne Larger, Philippe Boudou, Bertrand Blondeau, Ronan Roussel, Pascal Ferré, Eric Ravussin, François Rouzet, Michel Marre
Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134654 (2015)
Fetal exposure to hyperglycemia impacts negatively kidney development and function.Our objective was to determine whether fetal exposure to moderate hyperglycemia is associated with epigenetic alterations in DNA methylation in peripheral blood cells
Externí odkaz: https://doaj.org/article/3f09c623ffbe4a4aaff4e3731dc6f9cc
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7
Akademický článek
Novel transgenic mice for inducible gene overexpression in pancreatic cells define glucocorticoid receptor-mediated regulations of beta cells.
Autor: Bertrand Blondeau, Iman Sahly, Emmanuelle Massouridès, Amrit Singh-Estivalet, Bérengère Valtat, Delphine Dorchene, Frédéric Jaisser, Bernadette Bréant, Francois Tronche
Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30210 (2012)
Conditional gene deletion in specific cell populations has helped the understanding of pancreas development. Using this approach, we have shown that deleting the glucocorticoid receptor (GR) gene in pancreatic precursor cells leads to a doubled beta-
Externí odkaz: https://doaj.org/article/5539b34367ce41bcb9b2446660cb8495
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8
Insulin resistance-driven beta-cell adaptation in mice: Mechanistic characterization and 3D analysis
Autor: Alexandrine Liboz, Carine Beaupere, Natacha Roblot, Jean-Yves Tinevez, Sandra Guilmeau, Anne-Françoise Burnol, Dalale Gueddouri, Xavier Prieur, Bruno Fève, Ghislaine Guillemain, Bertrand Blondeau
Aims/hypothesisPancreatic beta cells secrete insulin to control glucose homeostasis. Beta cells can also adapt their function and mass when more insulin is required, especially in situations of insulin resistance (IR). Beta-cell mass adaptation can b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0aeccc61c9f5cdb512ac83d882ac864
https://doi.org/10.1101/2023.01.09.523222
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10
Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic beta-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE(2)Ki Mice on a Chronic High-Fat Diet
Autor: Mohamed-Naceur Slimane, Dominique Couchie, Berthold Büchele, Thomas Simmet, Mustapha Rouis, Bertrand Blondeau, Amna Abderrazak, Elodie Bosc, Khadija El Hadri
Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2016, 357 (3), pp.487-494. ⟨10.1124/jpet.116.232934⟩
Journal of Pharmacology and Experimental Therapeutics, 2016, 357 (3), pp.487-494. ⟨10.1124/jpet.116.232934⟩
International audience; Intraperitoneal injection of arglabin (2.5 ng/g of body weight, twice daily, 13 weeks) into female human apolipoprotein E-2 gene knock-in (ApoE(2)Ki) mice fed a high-fat Western-type diet (HFD) reduced plasma levels of glucose
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5ddb72d1fc8f650203bfe9a91422b5
https://hal.archives-ouvertes.fr/hal-01544052
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